Search results for " forming"

showing 10 items of 127 documents

Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens

2006

Abstract Mycobacterium tuberculosis infects one-third of the global population and claims two million lives every year. Because memory CD8 T cells exhibit a high heterogeneity in terms of phenotype and functional characteristic, we investigated the frequency, phenotype, and functional properties of Ag85A epitope-specific HLA-A*0201 CD8 T cells in children affected by tuberculosis (TB) before and 4 mo after chemotherapy and healthy contact children. Using Ag85A peptide/HLA-A*0201 pentamer, we found a low frequency of blood peptide-specific CD8 T cells in tuberculous children before therapy, which consistently increased after therapy to levels detected in healthy contacts. Ex vivo analysis of…

MalePore Forming Cytotoxic ProteinsLEPROSYImmunologyEpitopes T-LymphocyteCD8-Positive T-LymphocytesBiologyTuberculinTUBERCULOSISEpitopeImmunophenotypingInterferon-gammaInterleukin 21Immune systemImmunophenotypingAntigenT-Lymphocyte SubsetsHLA-A2 AntigenHumansBACILLE CALMETTE-GUERINImmunology and AllergyCytotoxic T cellLymphocyte CountChildTuberculosis PulmonaryAntigens BacterialMembrane GlycoproteinsIFN-GAMMACOMPLEXHLA-A AntigensPerforinHIGH-FREQUENCIESMycobacterium tuberculosisINTRACELLULAR INFECTIONNatural killer T cellVirologyBOVIS BCGMICEChild PreschoolTuberculosis MeningealImmunologyFemaleImmunologic MemoryCD8RESPONSES
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From equilibrium to steady state: The transient dynamics of colloidal liquids under shear

2008

We investigate stresses and particle motion during the start up of flow in a colloidal dispersion close to arrest into a glassy state. A combination of molecular dynamics simulation, mode coupling theory and confocal microscopy experiment is used to investigate the origins of the widely observed stress overshoot and (previously not reported) super-diffusive motion in the transient dynamics. A link between the macro-rheological stress versus strain curves and the microscopic particle motion is established. Negative correlations in the transient auto-correlation function of the potential stresses are found responsible for both phenomena, and arise even for homogeneous flows and almost Gaussia…

Materials scienceGaussianFOS: Physical sciencesCondensed Matter - Soft Condensed Matterconfocal microscopyMolecular dynamicssymbols.namesakeColloidddc:530General Materials ScienceColloids Glasses Shear Dynamics TransientMagnetosphere particle motionglass forming liquids under shearmode coupling serieDisordered Systems and Neural Networks (cond-mat.dis-nn)MechanicsCondensed Matter - Disordered Systems and Neural NetworksCondensed Matter PhysicsStart upmolecular dynamicsCondensed Matter::Soft Condensed MatterShear (geology)HomogeneousMode couplingsymbolsSoft Condensed Matter (cond-mat.soft)
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Beta forging of Ti-6Al-4V: Microstructure evolution and mechanical properties

2013

Titanium alloys are finding an increasing use in the aeronautical field, due to their characteristics of high mechanical properties, lightness and corrosion resistance. Moreover these alloys are compatible with the carbon fibre reinforced plastics that are also finding a wide use in the aeronautical field. On the other hand the use of these alloys implies some drawbacks, for example titanium alloys are often considered more difficult to form and generally have less predictable forming characteristics than other metallic alloys such as steel and aluminum. In this paper was studied both the microstructure evolution and the mechanical properties of a Ti-6Al-4V rolled bar after hot forging. The…

Materials scienceMechanical EngineeringAlloyMetallurgyTitanium alloychemistry.chemical_elementForming processesengineering.materialCompression (physics)MicrostructureForgingCorrosionCommercial codes Elevated temperature High mechanical properties Hot forming process Micro-structure evolutions Thermo-mechanical response Ti-6al-4v Ti-6Al-4V alloychemistryMechanics of MaterialsAluminiumengineeringGeneral Materials ScienceAlloy steel Aluminum Carbon fiber reinforced plastics Compression testing Corrosion resistance Forging Mechanical properties Titanium alloySettore ING-IND/16 - Tecnologie E Sistemi Di LavorazioneMicrostructureForging Ti-6Al-4V microstructure
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Synthesis of bulk FeAl nanostructured materials by HVOF spray forming and Spark Plasma Sintering

2006

Abstract This paper examines the efficiency of two consolidation processing techniques: High Velocity Oxy-Fuel (HVOF) spray forming and Spark Plasma Sintering (SPS) to obtain bulk nanostructured materials from an Y 2 O 3 reinforced Fe–40Al (at.%) milled powder. The microstructures of the sintered end-products were characterized by Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) in order to gain new insights in their microstructure formation mechanisms. HVOF spray forming is more effective to retain fine nanograins, in particular within retained unmelted powder particles. The drawbacks of this technique are that it inevitably leads to a high fraction of porosity…

Materials scienceScanning electron microscopeMechanical EngineeringMetallurgyMetals and AlloysSpark plasma sinteringFEALGeneral ChemistryMicrostructureSpray formingMechanics of MaterialsTransmission electron microscopyMaterials ChemistryThermal sprayingPorosityIntermetallics
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A depth dependent analytical approach to determine material breaking in SPIF

2007

Formability is a relevant issue in Single Point Incremental Forming (SPIF) process since it is one of the main point of strength together to the possibility to avoid any dedicated die. Several researches agree that, depending on working material and process parameters, in SPIF operations there is a threshold slope of the wall that cannot be overcame without material breaking. If deep Incremental Forming is taken into account, despite the previous statement it is possible to demonstrate that, when the threshold angle is imposed, there is a relation between the actual workpiece depth and the material breaking approaching. In this paper, the latter relationship was investigated and formally de…

Materials sciencebusiness.product_categoryANOVAbusiness.industryDepth dependentProcess (computing)Forming processesStructural engineeringMechanicsFracture (geology)Die (manufacturing)FormabilityPoint (geometry)incremental formingSingle pointmaterial formabilitybusinessSettore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione
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Development of Magnetic Field-Assisted Single-Point Incremental Forming

2021

Single Point Incremental Forming (SPIF) has recently introduced the concept of material formability enhancement through localized deformation. Since material is processed by means of a pin tool attached to spindle, physical interference (especially in vertical direction) limits attainable shapes with the conventional process. The aim of the following work is to increase the variety of achievable geometries with SPIF through in-process magnetic field assistance. An innovative configuration managing SPIF tool movement using magnetic force is proposed. With this in mind, a magnet configuration was designed to generate a vertical load able to plastically deform a 0.5 mm thick AA1100 aluminum sh…

Materials sciencechemistryMechanics of MaterialsAluminiumMechanical EngineeringMechanical engineeringchemistry.chemical_elementGeneral Materials ScienceDevelopment (differential geometry)Single pointIncremental sheet formingMagnetic fieldKey Engineering Materials
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Moving Least Squares Innovative Strategies For Sheet Forming Design

2011

In the last years a great interest in optimization algorithms aimed to design forming processes was demonstrated by many researches. Proper design methodologies to reduce times and costs have to be developed mostly based on computer aided procedures. Response surface methods (RSM) proved their effectiveness in the recent years also for the application in sheet metal forming aiming to reduce the number of numerical simulations. Actually, the main drawback of such method is the number of direct problem to be solved in order to reach good function approximations. A very interesting aspect in RSM application regards the possibility to build response surfaces basing on moving least squares appro…

Mathematical optimizationEngineeringOptimization problemComputer simulationbusiness.industryForming processesFunction approximationSheet metal forming design moving least squares optimizationvisual_artvisual_art.visual_art_mediumCurve fittingMoving least squaresSheet metalbusinessSettore ING-IND/16 - Tecnologie E Sistemi Di LavorazioneInterpolationAIP Conference Proceedings
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A contribution on the optimization strategies based on moving least squares approximation for sheet metal forming design

2012

Computer-aided procedures to design and optimize forming processes are, nowadays, crucial research topics since industrial interest in costs and times reduction is always increasing. Many researchers have faced this research challenge with various approaches. Response surface methods (RSM) are probably the most known approaches since they proved their effectiveness in the recent years. With a peculiar attention to sheet metal forming process design, RSM should offer the possibility to reduce the number of numerical simulations which in many cases means to reduce design times and complexity. Actually, the number of direct problems (FEM simulations) to be solved in order to reach good functio…

Mathematical optimizationEngineeringOptimization problembusiness.industryMechanical EngineeringForming processesComputer aided optimizationSheet metal formingIndustrial and Manufacturing EngineeringComputer Science ApplicationsReduction (complexity)Function approximationControl and Systems Engineeringvisual_artKey (cryptography)visual_art.visual_art_mediumZoomMoving least squaresMoving least squares methodologySheet metalbusinessSettore ING-IND/16 - Tecnologie E Sistemi Di LavorazioneSoftware
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A NEW PROGRESSIVE DESIGN METHODOLOGY FOR COMPLEX SHEET METAL STAMPING OPERATIONS: COUPLING SPATIALLY DIFFERENTIATED RESTRAINING FORCES APPROACH AND M…

2010

The growing interest in sheet metal stamping processes, particularly in the automotive industry has led to three main issues in this field:*request of very complex shapes; *growing interest in springback control; *solution of multi-objective problems. These issues make a sheet metal stamping processes design very difficult and proper design methodologies to reduce times and costs are highly required. In this paper, a computer aided approach aiming to satisfy the mentioned issues is proposed. In particular, a progressive design approach based on the integration between numerical simulations, Response Surface Methodology (RSM) and Pareto optimal solutions search techniques was applied in orde…

Mathematical optimizationEngineeringbusiness.industryMechanical EngineeringPareto principleAutomotive industrymulti-objective optimisatiomrestraining forces stategyProcess designStampingSheet metal formingMulti-objective optimizationComputer Science ApplicationsspringbackModeling and SimulationDesign processGeneral Materials SciencebusinessEngineering design processDesign methodsSettore ING-IND/16 - Tecnologie E Sistemi Di LavorazioneCivil and Structural Engineering
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Multi Stage Strategies for Single Point Incremental Forming of a Cup

2008

A five stage forming strategy for Single Point Incremental Forming of a circular cylindrical cup with a height/radius ratio of one is presented. Geometrical relations are discussed and theoretical strains are calculated. The influence of forming direction (upwards or downwards) is investigated for the second stage comparing explicit FE analysis with experiments. Good agreement is found between calculated and measured thickness distribution, overall geometry and strains. Using the proposed multi stage strategy it is shown possible to produce a cup with a height close to the radius and sides parallel to the symmetry axis in about half of the depth.

Mathematical optimizationFEMMaterials scienceMulti stagemental forming - multi stage - FEMIncremental formingGeometryRadiusFinite element methodSymmetry (physics)Multi stageDistribution (mathematics)General Materials ScienceStage (hydrology)Single pointSettore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione
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