Search results for " function"
showing 10 items of 9395 documents
A time-course investigation of vitamin A levels and drug metabolizing enzyme activities in rats following a single treatment with prototypic polychlo…
1987
Xenobiotics previously characterized as selective inducers of drug-metabolizing enzymes were chosen to probe possible relationships between enzyme induction and vitamin A metabolism. Liver, kidney and serum retinol and retinyl palmitate levels were investigated in male Sprague--Dawley rats receiving a single i.p. injection of the polychlorinated biphenyls (PCBs), 2,2',5,5'-tetrachlorobiphenyl, 3,3',4,4'-tetrachlorobiphenyl or 2,2',4,4',5,5'-hexachlorobiphenyl (300 mumol/kg) or 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)-ethane (DDT) (150 mumol/kg). While 2,2',5,5'-tetrachlorobiphenyl, a weak or non-inducer, and 2,2',4,4',5,5'-hexaclorobiphenyl and DDT, phenobarbital-type inducers of cytochrome…
Effects of vitamin A deficiency on mitochondrial function in rat liver and heart.
2000
The aim of this study was to investigate comparative effects of vitamin A deficiency on respiratory activity and structural integrity in liver and heart mitochondria. Male rats were fed a liquid control diet (control rats) or a liquid vitamin A-deficient diet (vitamin A-deficient rats) for 50 days. One group of vitamin-A deficient rats was refed a control diet for 15 days (vitamin A-recovered rats). To assess the respiratory function of mitochondria the contents of coenzyme Q (ubiquinone, CoQ), cytochrome c and the activities of the whole electron transport chain and of each of its respiratory complexes were evaluated. Chronic vitamin A deficiency promoted a significant increase in the endo…
Density Functional Theory Calculated Raman Spectra of Ergocalciferol (Vitamin D2) and Cholecalciferol (D3)
2021
Density functional theory (DFT)-calculated Infrared and Raman spectra of Vitamin D2 and D3 are presented. The calculated results are compared with each other and with available experimental data. Applicability of Raman spectra for non-invasive optical Vitamin D sensors is discussed.
Test fairness: a DIF analysis of an L2 vocabulary test
2000
The purpose of this study is to analyse gender-uniform differential item functioning (DIF) in a second language (L2) vocabulary test with the tools of item response theory (the separate calibration t-method) and to study potential gender impact on the test performance measured by different item composites. The results of the study show that despite the fact that there are test items with indications of DIF in favour of either females or males, the test as a whole is not gender-biased. In spite of this, it was demonstrated that some item composites are gender-biased. In view of item bank building and use, it means that some of the tests constructed on the basis of an item bank might be bias…
An Integrative Approach for Product Development and Customer Satisfaction Measurement
1999
As soon as the automotive industry in the western world countries recognizes that the outstanding performance of Japanese manufacturers is the result of a customer-oriented understanding of quality, the QFD approach became a famous instrument to achieve the product quality demanded by customers. Nevertheless this concept has its limits. In this article we suggest the extension of the QFD approach on the base of customer values and benefits.
Simplified Hybrid PD Model in Voids
2011
In this paper a novel approach to model partial discharges (PD) activity taking place inside a spherical void in epoxy resin system has been traced. The approach is based on a time varying conductance of the inner void, subjected to multistress conditions: voltage, temperature and pressure. A simple lumped circuit macro-model simulates the global effects of PD activity: the different parameters influencing the discharge phenomenon in the void are taking into account by using a physical approach resulting in a time varying conductance inside the circuit. The evaluated PD activity has been compared with experimental and simulated one for the accessible and inaccessible part of the system. A d…
Simplified hybrid PD model in voids: Pattern validation
2013
The purpose of the present work is to show the validation of a new model to simulate the physical phenomenon of partial discharge (PD) produced in air voids inside insulating epoxy resin. The model has been developed on the basis of a new approach that combines the known circuit model of three capacitors with a model used to describe the behavior of the ionized channel inside of the inclusion during the discharge phenomenon, short-circuiting the capacity that represents the void. The approach is based on time-variable conductance of the void, subjected to multistress conditions: voltage, temperature and pressure. The new approach has been developed from a time variable conductivity model us…
Physiological pharmacokinetic model for ceftazidime disposition in the rat and its application to prediction of plasma concentrations in humans
1993
Abstract A physiological pharmacokinetic model for the disposition of ceftazidime in the rat was developed. The model is composed of 10 compartments which represent most of the organs and tissues of the body. Ceftazidime concentration-time profiles in the organs and tissues represented in the model were simulated and compared with the observed concentration-time data after i.v. administration of 5 and 20 mg of antibiotic. The model gave an acceptable description of the observed data. The steady-state volume of distribution and total clearance of ceftazidime in healthy humans predicted from data obtained in the rat (0.21 l/kg and 113 ml/min, respectively) were similar to the values reported …
Pharmacokinetic/Pharmacodynamic Model of Neutropenia in Real-Life Palbociclib-Treated Patients
2021
Palbociclib is an oral CDK4/6 inhibitor indicated in HR+/HER2- advanced or metastatic breast cancer in combination with hormonotherapy. Its main toxicity is neutropenia. The aim of our study was to describe the kinetics of circulating neutrophils from real-life palbociclib-treated patients. A population pharmacokinetic (popPK) model was first constructed to describe palbociclib pharmacokinetic (PK). Individual PK parameters obtained were then used in the pharmacokinetic/pharmacodynamic (PK/PD) model to depict the relation between palbociclib concentrations and absolute neutrophil counts (ANC). The models were built with a population of 143 patients. Palbociclib samples were routinely collec…
Voriconazole and the liver.
2015
Voriconazole is an azole useful for the prophylaxis and the treatment of aspergillosis and other fungal infections in immunosuppressed subjects, as those found in aplasia after aggressive polychemotherapy treatments, after hematopoietic stem cell, liver or lung transplantation. Its administration in therapeutic doses lead to extremely varied serum levels from patient to patient and even to the same patient. The explanations are varied: nonlinear pharmacokinetics, certain patient-related factors, including genetic polymorphisms in the cytochrome P450 2C19 gene, the kidney and liver function, simultaneous administration with other drugs metabolised by the same cytochrome. It is recommended to…