Search results for " gadolinium"

Asimmetric skeleton patterns induced by gadolinium ions in sea urchin embryos: focus on mechanisms regulating skeletogenesis and comparison among phy…

2014

Mixed micelles composed of Peptides and Gadolinium complexes as tumor-specific contrast agents in MRI: a SANS study

2004

A detailed structural investigation on mixed micelle aggregates as target-specific contrast agents for magnetic resonance imaging technique has been carried out by way of small angle neutron scattering measurements. These mixed micelles are formed by two new amphiphilic molecules formed by a bioactive peptide and a claw moiety. The first molecule, C18H37CONH(AdOO)(x)-G-CCK8 (C18LxCCK8, x = 2, 5), contains an 18-carbon-atom alkylic chain bound to the C-terminal of the cholecystokinin octapeptide amide (CCK 26-33 or CCK8) and is able to bind to the overexpressed CCK receptor of some tumor cells. The second molecule, C(18)H(37)CONHLys(DTPAGlu)CONH25- (C18DTPAGlu) or its gadolinium complex [C(1…

Using Polynomial Loss and Uncertainty Information for Robust Left Atrial and Scar Quantification and Segmentation

2022

Automatic and accurate segmentation of the left atrial (LA) cavity and scar can be helpful for the diagnosis and prognosis of patients with atrial fibrillation. However, automating the segmentation can be difficult due to the poor image quality, variable LA shapes, and small discrete regions of LA scars. In this paper, we proposed a fully-automatic method to segment LA cavity and scar from Late Gadolinium Enhancement (LGE) MRIs. For the loss functions, we propose two different losses for each task. To enhance the segmentation of LA cavity from the multicenter dataset, we present a hybrid loss that leverages Dice loss with a polynomial version of cross-entropy loss (PolyCE). We also utilize …

CELLULAR AND MOLECULAR MECHANISMS ACTIVATED IN SEA URCHIN EMBRYOS EXPOSED TO GADOLINIUM, EMERGING ENVIRONMENTAL CONTAMINANT

EPR/ALANINE PELLETS WITH LOW Gd CONTENT FOR NEUTRON DOSIMETRY

2013

This paper reports on results obtained by electron paramagnetic resonance (EPR) measurements and Monte Carlo (MC) simulation on a blend of alanine added with low content of gadolinium oxide (5 % by weight) to improve the sensitivity to thermal neutron without excessively affecting tissue equivalence. The sensitivity is enhanced by this doping procedure of more an order of magnitude. The results are compared with those obtained with the addition of boric acid (50 % by weight) where boron is in its natural isotopic composition in order to produce low-cost EPR dosemeters. The gadolinium addition influences neutron sensitivity more than the boron addition. The presence of additives does not sub…

Direct detection of 17O NMR in [Gd(DOTA)]- by NMR Spectroscopy

2015

The 17O NMR spectrum of the non-coordinated carboxyl oxygen in the GdIII-DOTA (DOTA = tetraazacyclododecanetetraacetic acid) complex has been observed experimentally. Its line width is essentially unaffected by paramagnetic relaxation due to gadolinium, and is only affected by the quadrupole pathway. The results are supported by the relevant parameters (hyperfine and quadrupole coupling constants) calculated by relativistic DFT methods. This finding opens up new avenues for investigating the structure and reactivity of paramagnetic GdIII complexes used as contrast agents in magnetic resonance imaging.

401Prognostic role of late gadolinium enhancement in patients with low-intermediate 5 year HCM SCD risk score: a multicenter study

2018

324Prognostic role of late gadolinium enhancement in patients with low or intermediate HCM SCD risk score: a multicenter study

2019

Gadolinium accumulation after contrast-enhanced magnetic resonance imaging: Which implications in patients with Crohn's disease?

2017

Crohn's disease (CD) is a chronic inflammatory condition of the bowel, characterized by an alternation of remission and relapse phases, leading to a progressive intestinal damage with loss of function. Magnetic resonance enterography has been widely used in the past for the evaluation of fistulizing disease, but its use increased over time, being considered helpful in different moments of disease course. Intravenous injection of Gadolinium-based contrast agents has been demonstrated to be crucial to assess mucosal inflammation, transmural involvement, and extraintestinal disease. Recently, Gadolinium accumulation in human tissues has been increasingly reported, although clinical implication…

Efficient 3D Deep Learning for Myocardial Diseases Segmentation

2021

Automated myocardial segmentation from late gadolinium enhancement magnetic resonance images (LGE-MRI) is a critical step in the diagnosis of cardiac pathologies such as ischemia and myocardial infarction. This paper proposes a deep learning framework for improved myocardial diseases segmentation. In the first step, we build an encoder-decoder segmentation network that generates myocardium and cavity segmentations from the whole volume, followed by a 3D U-Net based on Shape prior to identifying myocardial infarction and myocardium ventricular obstruction (MVO) segmentations from the encoder-decoder prediction. The proposed network achieves good segmentation performance, as computed by avera…