Search results for " generation"

Targeting the tumor mutanome for personalized vaccination therapy

2012

Next generation sequencing enables identification of immunogenic tumor mutations targetable by individualized vaccines. In the B16F10 melanoma system as pre-clinical proof-of-concept model, we found a total of 563 non-synonymous expressed somatic mutations. Of the mutations we tested, one third were immunogenic. Immunization conferred in vivo tumor control, qualifying mutated epitopes as source for effective vaccines.

Usher syndrome : molecular analysis of USH2 genes and development of a next-generation sequencing platform

2013

El síndrome de Usher (USH) es una enfermedad hereditaria autosómica recesiva, caracterizada por la asociación de hipoacusia neurosensorial, retinosis pigmentaria y, en ocasiones, alteración de la función vestibular. Clínicamente, el USH se puede clasificar en tres tipos (USH1, USH2 y USH3), principalmente en base a la gravedad y progresión de la hipoacusia y presencia o no de disfunción vestibular. El USH es heterogéneo tanto a nivel clínico como genético y, hasta la fecha, se han descrito 11 genes implicados en la enfermedad. El USH2 es la forma más común y tres son los genes responsables conocidos: USH2A (72 exones), GPR98 (90 exones) y DFNB31 (12 exones). USH2A es responsable de más del …

Microbial controls of greenhouse gas emissions from boreal lakes

2015

Critical issues and future prospects of the secondary substation in smart grid context

2014

This paper is focused on the new role of the secondary substation in the smart grids context. This innovative view has been proposed and developed in the framework of two Research Projects: NewCabELARC Project and Reipersei Project. The latter provides a concrete and comprehensive low cost solutions for the smart grid monitoring and control, allowing the real diffusion and integration of Distributed Generation and the full exploitation of Renewable Energy Sources. In this field, this paper shows how the secondary substation (SS) takes the role of smart transducer node where innovative devices can be located, collecting the measurement data coming from the field devices (power and energy met…

A universal optical all-fiber omnipolarizer

2012

International audience; Wherever the polarization properties of a light beam are of concern, polarizers and polarizing beamsplitters (PBS) are indispensable devices in linear-, nonlinear- and quantum-optical schemes. By the very nature of their operation principle, transformation of incoming unpolarized or partially polarized beams through these devices introduces large intensity variations in the fully polarized outcoming beam(s). Such intensity fluctuations are often detrimental, particularly when light is post-processed by nonlinear crystals or other polarization-sensitive optic elements. Here we demonstrate the unexpected capability of light to self-organize its own state-of-polarizatio…

Measurement of the soliton number in guiding media through continuum generation.

2020

No general approach is available yet to measure directly the ratio between chromatic dispersion and the nonlinear coefficient, and hence the soliton number for a given optical pulse, in an arbitrary guiding medium. Here we solve this problem using continuum generation. We experimentally demonstrate our method in polarization-maintaining and single-mode fibers with positive and negative chromatic dispersion. Our technique also offers new opportunities to determine the chromatic dispersion of guiding media over a broad spectral range while pumping at a fixed wavelength. (C) 2020 Optical Society of America

Simultaneous polarization attraction and Raman amplification of a light beam in optical fibers

2012

International audience; In this paper, we demonstrate that it is possible to combine both Raman amplification and polarization attraction of a signal wave in a single optical fiber by means of a counterpropagating scheme. Experiments were performed near 1550 nm in a continuous wave regime and by means of a 10 Gbit ∕ s return-to-zero signal injected in a 20 kmlong low polarization mode dispersion optical fiber. Complete repolarization and 6.7 dB amplification of the signal wave was achieved by injecting a 850 mW, 1480 nm counterpropagating polarized pump wave.

Even harmonic pulse train generation by cross-polarization-modulation seeded instability in optical fibers

2012

International audience; We show that, by properly adjusting the relative state of polarization of the pump and of a weak modulation, with a frequency such that at least one of its even harmonics falls within the band of modulation instability, one obtains a fully modulated wave at the second or higher even harmonic of the initial modulation. An application of this principle to the generation of a 80-GHz optical pulse train with high extinction ratio from a 40-GHz weakly modulated pump is experimentally demonstrated using a nonzero dispersion shifted fiber in the telecom C band.

On a numerical solution of the Maxwell equations by discrete exterior calculus

2014

Collision Avoidance with Potential Fields Based on Parallel Processing of 3D-Point Cloud Data on the GPU

2014

In this paper we present an experimental study on real-time collision avoidance with potential fields that are based on 3D point cloud data and processed on the Graphics Processing Unit (GPU). The virtual forces from the potential fields serve two purposes. First, they are used for changing the reference trajectory. Second they are projected to and applied on torque control level for generating according nullspace behavior together with a Cartesian impedance main control loop. The GPU algorithm creates a map representation that is quickly accessible. In addition, outliers and the robot structure are efficiently removed from the data, and the resolution of the representation can be easily ad…