Search results for " glucose metabolism"

showing 2 items of 12 documents

Diabetes Secondary to Acromegaly: Physiopathology, Clinical Features and Effects of Treatment.

2018

Acromegaly is a rare disease due to chronic GH excess and to the consequent increase in IGF-1 levels. Both GH and IGF-1 play a role in intermediate metabolism affecting glucose homeostasis. Indeed, chronic GH excess impairs insulin sensitivity, increases gluconeogenesis, reduces the glucose uptake in adipose tissue and muscle and alters pancreatic β cells function. As a consequence, glucose metabolism alterations are a very frequent complication in acromegaly patients, further contributing to the increased cardiovascular risk and mortality. Treatment modalities of acromegaly differently impact on glucose tolerance. Successful surgical treatment of acromegaly ameliorates glucose metabolism a…

medicine.medical_specialtyGlucose uptakeMini Reviewglucose metabolismEndocrinology Diabetes and Metabolism030209 endocrinology & metabolismCarbohydrate metabolismpituitary tumorlcsh:Diseases of the endocrine glands. Clinical endocrinologySettore MED/13 - EndocrinologiaImpaired glucose tolerance03 medical and health scienceschemistry.chemical_compound0302 clinical medicineEndocrinologyInternal medicineDiabetes mellitusAcromegalymedicineGlucose homeostasislcsh:RC648-665diabetesbusiness.industrymedicine.diseasePasireotideGHEndocrinologyimpaired glucose toleranceAcromegaly Diabetes GH Glucose metabolism IGF-1 Impaired glucose tolerance Pituitary tumor Endocrinology Diabetes and Metabolismchemistry030220 oncology & carcinogenesisPegvisomantAcromegalyIGF-1businessmedicine.drug
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Perturbed Glucose Metabolism: Insights into Multiple Sclerosis Pathogenesis

2014

Multiple sclerosis (MS) is a complex debilitating disease of the central nervous system perceived to result from the autoimmune effect of T cells in damaging myelin sheath. However, the exact pathogenesis of the disease remains elusive. Initial studies describing the possibility of defective pyruvate metabolism in MS were performed in 1950s. The group observed elevated blood pyruvate level in both fasting and postprandial times in MS patients with relapse. Similarly, other investigators also reported increased fasting pyruvate level in this disease. These reports hint to a possible abnormality of pyruvate metabolism in MS patients. In addition, increase in levels of Krebs cycle acids like a…

medicine.medical_specialtyMini ReviewCentral nervous systemDiseaseCarbohydrate metabolismBioinformaticsmultiple sclerosislcsh:RC346-429PathogenesisInternal medicinebrain glucose metabolismmedicineneurodegenerative diseaseslcsh:Neurology. Diseases of the nervous systemmitochondrial defectsbusiness.industryMultiple sclerosisand neurodegenerative diseasesmedicine.diseasecell-specific mechanismsReview articleCitric acid cycleMetabolic pathwaymedicine.anatomical_structureEndocrinologyNeurologyNeurology (clinical)businessNeuroscienceFrontiers in Neurology
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