Search results for " heat"
showing 10 items of 830 documents
Optimal control in models with conductive‐radiative heat transfer
2003
In this paper an optimal control problem for the elliptic boundary value problem with nonlocal boundary conditions is considered. It is shown that the weak solutions of the boundary value problem depend smoothly on the control parameter and that the cost functional of the optimal control problem is Frechet differentiable with respect to the control parameter. Optimalus valdymas modeliuose su laidžiu-radioaktyviu šilumos pernešimu Santrauka Darbe nagrinejamas nelokalaus kraštinio uždavinio optimalaus valdymo uždavinys. Parodyta, kad silpnasis kraštinio uždavinio sprendinys tolydžiai priklauso nuo valdomojo parametro, taigi, optimalaus valdymo tikslo funkcija yra diferencijuojama Freše prasme…
Extracellular heat shock proteins in cancer: From early diagnosis to new therapeutic approach
2021
In cancer, human cells lose the ability to properly control the series of events that occur constantly during cell growth and division, including protein expression, stability, and dynamics. Heat shock proteins (Hsps) are key molecules in these events, constitutively expressed at high levels and could furthermore be induced by the response to cancer-induced stress. In tumor cells, Hsps have been shown to be implicated in the regulation of apoptosis, immune responses, angiogenesis and metastasis; in some cases, they can be overexpressed and dysregulated, representing important cancer hallmarks. In the past few years, it has been demonstrated that Hsps can be released by tumor cells through s…
Inhibition of HSP27 blocks fibrosis development and EMT features by promoting Snail degradation
2013
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by myofibroblast proliferation. Transition of epithelial/mesothelial cells into myofibroblasts [epithelial-to-mesenchymal transition (EMT)] occurs under the influence of transforming growth factor (TGF)-β1, with Snail being a major transcription factor. We study here the role of the heat-shock protein HSP27 in fibrogenesis and EMT. In vitro, we have up- and down-modulated HSP27 expression in mesothelial and epithelial cell lines and studied the expression of different EMT markers induced by TGF-β1. In vivo, we inhibited HSP27 with the antisense oligonucleotide OGX-427 (in phase II clinical trials as anticancer agent)…
Elevated cortisol modulates hsp70 and hsp90 gene expression and protein in sea bass head kidney and isolated leukocytes
2012
In fish, interactions between Hsps and cortisol are involved in stress modulated physiological processes including innate immune responses. Cortisol exerts a role in the regulation of Hsps synthesis. Fish head kidney is a lymphomieloid and endocrine organ releasing cortisol, and it is the central organ for immune-endocrine interactions. In sea bass, cortisol intraperitoneal injection and in vitro treatment of head kidney cells show that inducible Hsp70 and Hsp90 are modulated by this hormone. However, an inverse relationship between mRNA expression (real-time PCR) and Hsp70 and Hsp90 protein levels (densitometric band analysis) was found. Time-course assays indicate a cortisol-mediated regu…
Thermoelectrics: From history, a window to the future
2019
Thermoelectricity offers a sustainable path to recover and convert waste heat into readily available electric energy, and has been studied for more than two centuries. From the controversy between Galvani and Volta on the Animal Electricity, dating back to the end of the XVIII century and anticipating Seebeck’s observations, the understanding of the physical mechanisms evolved along with the development of the technology. In the XIX century Ørsted clarified some of the earliest observations of the thermoelectric phenomenon and proposed the first thermoelectric pile, while it was only after the studies on thermodynamics by Thomson, and Rayleigh’s suggestion to exploit the Seebeck effect for …
Human Enterovirus Group B Viruses Rely on Vimentin Dynamics for Efficient Processing of Viral Nonstructural Proteins.
2019
A virus needs the host cell in order to replicate and produce new progeny viruses. For this, the virus takes over the host cell and modifies it to become a factory for viral proteins. Irrespective of the specific virus family, these proteins can be divided into structural and nonstructural proteins. Structural proteins are the building blocks for the new progeny virions, whereas the nonstructural proteins orchestrate the takeover of the host cell and its functions. Here, we have shown a mechanism that viruses exploit in order to regulate the host cell. We show that viral protein synthesis induces vimentin cages, which promote production of specific viral proteins that eventually control apo…
Promoting the Flexibility of Thermal Prosumers Equipped with Heat Pumps to Support Power Grid Management
2023
The increasing share of renewable energy sources in energy systems will lead to unpredictable moments of surplus/deficit in energy production. To address this issue, users with heat pumps can provide support to power grid operators through flexible unit operation achieved via Demand Response programs. For buildings connected to low-temperature heating networks with ensured third-party access, further room for flexibility can be explored by investigating the production of surplus heat that can be sold to the network. A key aspect lies in the identification of the energy pricing options that could encourage such flexible operation of a heat pump by “thermal prosumers”. To this aim…
Impact of processing conditions on functionality of powders prepared from mixed protein system
2020
International audience; The projection of a global human population of around 9.5 billion by 2050 indicates that the demand for animal protein will double during this period. It seems therefore essential in regard to sustainability and food security to search for alternative protein sources that show nutritional and functional quality close to animal protein ones. In that respect, there is a growing interest in utilizing plant proteins as partial replacers of animal proteins in food. The reintroduction of plant proteins into our diet is a solution already envisaged by some vegetarian or flexitarian diets. In order to broaden this practice, one strategy is the use of protein mixes as an ingr…
Induction of Hsp70 by the Herbicide Oxyfluorfen (Goal) in the Egyptian Nile Fish, Oreochromis niloticus
1999
This paper deals with the expression of the biomarker hsp70 in the liver and kidney of the freshwater fish Oreochromis niloticus following exposure to the herbicide oxyfluorfen (Goal). Fishes were exposed to three concentrations, the 96-h LC50 (3 mg/L), the 96-h (1/2)LC50 (1.5 mg/L), and the 96-h (1/4)LC50 (0.75 mg/L) of oxyfluorfen for 6, 15, and 24 days, respectively, and samples were taken at three different time periods for each concentration. The livers responded to the herbicide by an induction of the expression of both the constitutive (hsp75; Mr 75 kDa) and the inducible (hsp73; Mr 73 kDa) hsp70 proteins. In kidney, the herbicide induced a time-dependent increase in the expression o…
Le repérage des patients en situation de précarité par les médecins généralistes
2019
Cette étude se propose d’étudier la concordance entre un repérage de la précarité effectué spontanément par les médecins généralistes et un repérage effectué par le score EPICES (évaluation de la précarité et des inégalités de santé dans les centres d’examens de santé), développé et validé dans les centres d’examens de santé.Les 32 médecins généralistes ont permis d’inclure 207 patients dans l’étude. Le coefficient de concordance Kappa de Cohen était de 0,404, soit une corrélation faible à modérée.L’étude des variables associées à la concordance de ce repérage n’a permis de dégager aucune variable significativement associée à la concordance après une analyse multivariée.Pour conclure, le re…