Search results for " heat"

Approximation of heat equation and backward SDEs using random walk : convergence rates

2018

This thesis addresses questions related to approximation arising from the fields of stochastic analysis and partial differential equations. Theoretical results regarding convergence rates are obtained by using discretization schemes where the limiting process, the Brownian motion, is approximated by a simple discrete-time random walk. The rate of convergence is derived for a finite-difference approximation of the solution of a terminal value problem for the backward heat equation. This weak approximation result is proved for a terminal function which has bounded variation on compact sets. The sharpness of the according rate is achieved by applying some new results related to the first exit time …

UV-B exposure causes DNA damage and changes in protein expression in northern pike (Esox lucius) posthatched embryos.

2012

The ongoing anthropogenically caused ozone depletion and climate change has increased the amount of biologically harmful UV-B radiation, which is detrimental to fish in embryonal stages. The effects of UV-B radiation on the levels and locations of DNA damage manifested as cyclobutane pyrimidine dimers (CPDs), heat shock protein 70 (HSP70) and p53 protein in newly hatched embryos of pike were examined. Pike larvae were exposed in the laboratory to current and enhanced doses of UV-B radiation. UV-B exposure caused the formation of CPDs in a fluence rate-dependent manner, and the CPDs were found deeper in the tissues with increasing fluence rates. UV-B radiation induced HSP70 in epidermis, and…

Targeting HSP90 with the small molecule inhibitor AUY922 (luminespib) as a treatment strategy against hepatocellular carcinoma

2018

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to existing therapies, most probably due to its extraordinary inter- and intra-tumor molecular heterogeneity. The modest therapeutic response to molecular targeted agents underlines the need for new therapeutic approaches for HCC. In our study, we took advantage of well-characterized human HCC cell lines, differing in transcriptomic subtypes, DNA mutation and amplification alterations, reflecting the heterogeneity of primary HCCs, to provide a preclinical evaluation of the specific heat shock protein 90 (HSP90) inhibitor AUY922 (luminespib). Indeed, HSP90 is highly expressed in different tumor types, but it…

Heat shock protein 70 and exercise: morphofunctional relationships

2008

"Thermal penalty factors" accounting for site topological characteristics in pinch design of Heat Exchanger Networks

2010

Pinch analysis allows to determine targets and solutions for minimum energy requirements in process plants, basing on innovative tools like composite curves and table problem formulation, which ultimately allow generating an optimized heat exchanger network design. On another hand, this technique does not account directly for a number of factors which could play a primary role for the practical feasibility of the network. What if, for instance, once identified an optimal lay-out, we realize that some matches are hardly feasible in practice? Could we adapt the conventional pinch approach to keep into account site topological features since the preliminary design phase? In this paper the auth…

Quasi-periodical kinetic instabilities in minimum-B confined plasma

2022

We present the results of an experimental investigation of quasi-periodical kinetic instabilities exhibited by magnetically confined electron cyclotron resonance heated plasmas. The instabilities were detected by measuring plasma microwave emission, electron losses, and wall bremsstrahlung. The instabilities were found to be grouped into fast sequences of periodic plasma losses, separated by ∼100 µs between the bursts, followed by 1–10 ms quiescent periods before the next event. Increasing the plasma energy content by adjusting the plasma heating parameters, in particular the magnetic field strength, makes the instabilities more chaotic in the time domain. Statistical analysis reveals that …

The use of in-line quantitative analysis to follow polymer processing

2009

In this work it is presented three applications of real time analysis during extrusion process using an optical device developed by our research group, which applies the concepts of light extinction. Monitoring of polymer blends morphology takes place to infer data concerned to dispersed phase size and concentration. The detector also enables information about melting temperature of polymer during extrusion and the level of viscous heating, and the exfoliation step during processing of a polymer-clay nanocomposite.

Impact of Separator Thickness on Temperature Distribution in Single Cell of Polymer Electrolyte Fuel Cell Operated at Higher Temperature of 90 °C and…

2022

The New Energy and Industry Technology Development Organization (NEDO) road map (Japan, 2017) has proposed that a polymer electrolyte fuel cell (PEFC) system, which operates at a temperature of 90 °C and 100 °C, be applied for stationary and mobility usage, respectively. This study suggests using a thin polymer electrolyte membrane (PEM) and a thin gas diffusion layer (GDL), at the same time, to achieve better power-generation performance, at a higher temperature than usual. The focus of this paper is to clarify the effect of separator thickness on the distribution of temperature at the reaction surface (Treact), with the relative humidity (RH) of the supply gasses and initial operation tem…

DEVELOPMENT OF A NEW SATURATED VAPOUR-ANODE, SATURATED VAPOUR-CATHODE AMTEC-LIKE DEVICE

Photoinduced lethal and sublethal toxicity of retene, a polycyclic aromatic hydrocarbon derived from resin acid, to coregonid larvae

2004

A comparative investigation on the acute phototoxicity of retene to vendace (Coregonus albula) and whitefish (C. lavaretus), both having pelagial larvae in spring, was conducted. To test the concept of early warning of sublethal biomarkers in relation to lethality to posthatch stages, we examined the effects of ultraviolet-B (UV-B) and retene on the levels of cytochrome P4501A (CYP1A) and heat shock protein 70 (HSP70) by exposing the animals to elevated levels of these factors for 48 and 72 h, respectively. Whereas UV-B and retene on their own were not lethal, simultaneous retene and UV-B exposure caused very high mortality to both species. The median lethal concentration (LC50; i.e., the c…