Search results for " histone deacetylase"

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Induction of Apoptosis and Chemosensitization by the Histone Deacetylase Inhibitor Trichostatin in Hepatocellular Carcinoma Cells: Molecular Analysis…

2011

The mRNA and protein levels of RKIP are reduced and those of YY1 increased in clinical HCC. Loss, mutation, or promoter hypermethylation of the RKIP gene may not account for the downregulation of RKIP in HCC. Histone deacetylation can silence gene expression and play a significant role in hepatocarcinogenesis. The histone deacetylase inhibitor (HDACI) trichostatin induced cell growth inhibition and proapoptotic effects in HA22T/VGH and HepG2 HCC cells; it also exhibited synergy with doxorubicin. Treatment with trichostatin caused histone hyperacetylation and down- or upregulated expression of different genes (such as β-catenin, cyclin D1, hTERT, XIAP, and IL-6). These changes might, at leas…

hepatocellular carcinoma Raf-1 kinase inhibitor protein Yin Yang 1 gene expression histone deacetylase inhibitor trichostatin apoptosis chemosensitizationHistone deacetylase 5medicine.drug_classChemistryHDAC11Histone deacetylase inhibitormedicine.diseaseBiochemistryMolecular biologyMolecular analysisApoptosisChemosensitizationHepatocellular carcinomaGene expressionGeneticsmedicineCancer researchSettore BIO/14 - FarmacologiaMolecular MedicineBiotechnology

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PEPhysical Sciences and Engineering
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