Search results for " igiene"

Arginine-Rich Peptidomimetic Ampicillin/Gentamicin Conjugate To Tackle Nosocomial Biofilms: A Promising Strategy To Repurpose First-Line Antibiotics

2023

: Combined therapy with penicillins and aminoglycosides has been proved beneficial to address many persistent bacterial infections with possible synergistic effects. However, the different pharmacokinetic profiles of these two antibiotic classes may not guarantee a concerted spatio-temporal delivery at the site of action, decreasing the efficacy of this combination and promoting resistance. Herein, we propose a multifunctional antibiotic-polymer conjugate, designed to colocalize ampicillin and gentamicin to tackle persistent biofilm infections. The two antibacterial molecules were grafted along with the amino acid l-arginine to a biocompatible polymer backbone with peptidomimetic hydrophili…

Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU/EEA countries, weeks 38/2020 to 10/2021

2021

COVID study groups - PORTUGAL: Portuguese Laboratory Network for the Diagnosis of COVID-19 and Public Health Department of the Health Administrative Regions, Physicians that provided data and samples from suspected cases and SARS-CoV-2 genetic characterization. INSA laboratory team for the diagnosis of SARS-CoV-2. Algarve Biomedical Center and Unilabs. We compared 19,207 cases of SARS-CoV-2 variant B.1.1.7/S gene target failure (SGTF), 436 B.1.351 and 352 P.1 to non-variant cases reported by seven European countries. COVID-19 cases with these variants had significantly higher adjusted odds ratios for hospitalisation (B.1.1.7/SGTF: 1.7, 95% confidence interval (CI): 1.0-2.9; B.1.351: 3.6, 95…

“Parassitosi intestinali: conoscenze, comportamenti e influenza di fattori socio familiari in un campione di alunni e docenti di Scuola Primaria”

2008

Il ruolo delle infezioni da Chlamydia nel determinismo delle malattie cronico-degenerative: una nuova sfida per i sistemi sanitari

2009

Le infezioni da Chlamydia stanno riscuotendo una rinnovata attenzione da quando è stato postulato che proteine rilasciate da questi batteri intracellulari possono generare fenomeni di autoimmunità e l’insorgenza di diverse malattie, come l’Alzheimer, l’aterosclerosi, l’arterite reumatoide, la sclerosi multipla e numerose altre ancora. Questo breve articolo ha lo scopo di stressare il problema che, negli Stati Uniti, rappresenta già una emergenza sanitaria

Vaccination against the 2009 pandemic influenza A (H1N1) among healthcare workers in the major teaching hospital of Sicily (Italy).

2010

Survey on knowledge, attitudes and practices of Italian Resident of Public Health towards influenza vaccination

2012

Background: Public Health Residents (PHRs) have to be considered of relevant interest among health care workers (HCWs) since they are strongly asked to recommend and perform influenza vaccination to other HCWs and general population. Despite this consideration, Italian HCWs have influenza vaccination rates significantly below the 75% coverage proposed by International Public Health guidelines. In order to increase future coverage towards influenza vaccination, the aim of this study is to assess determinants associated with influenza vaccine uptake among Italian PHR. Methods: A survey was carried out on PHRs attending 25 out 32 Post-Graduate University training programmes on Public Health in…

Sorveglianza della nuova influenza H1N1 in Sicilia

2009

Carlina acaulis and Trachyspermum ammi essential oils formulated in protein baits are highly toxic and reduce aggressiveness in the medfly, Ceratitis…

2021

Abstract Essential oil (EO)-based botanical insecticides are considered a promising option for Integrated Pest Management (IPM). However, the sublethal effects of EO-based insecticides are understudied. No information is available on the potential effects of EO exposure on insect aggressive traits. In this study, the toxicity of two EOs with documented efficacy on insect vectors and agricultural pests, and which were obtained from the roots of silver thistle (Carlina acaulis L., Asteraceae) and seeds (i.e. schizocarps) of ajwain (Trachyspermum ammi (L.) Sprague, Apiaceae), was evaluated against adults of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann) (medfly), a cosmopolitan fr…

An intercalibration study of the use of 4-Methyumbelliferyl-ß-D-glucuronide for the specific enumeration of Escherichia coli in seawater and marine s…

1991

A fluorogenic assay for the specific detection of Escherichia coli on the basis of its β-glucuronidase activity (MUG method) was applied to seawater and marine sediments with different contamination levels. The study was carried out in three Mediterranean areas (Malaga-Spain, Nice-France and Palermo-Sicily), using strictly standardized methods (membrane filtration), media (mFC and Chapman-TTC agars) and reagents, to evaluate statistically its sensitivity and specificity according to the origin and contamination of samples, the workers performing the tests and the selected culture media. The results obtained indicate that the MUG method is highly specific (94.5%) and sensitive (90.8%) for th…

DETECTION OF HIV TYPE 1 (HIV-1) NON-B SUBTYPES IN SICILY, ITALY

2004

To evaluate the presence of HIV-1 non-B subtypes in Sicily, we sequenced and genotyped HIV-1 PR and RT regions of the pol gene using plasma from 169 HIV-1-infected adult patients. All samples were obtained from a study of antiretroviral-associated resistance mutations resulting in virological failure during highly active antiretroviral therapy (HAART). Eight (4.7%) patients had the non-B HIV-1 subtype including some circulating recombinant forms (CRFs). All of these individuals acquired the infection by heterosexual transmission. The detection of HIV-1 non-B strains was significantly associated with younger age of HIV-1 acquisition. Our findings indicate, for the first time, the presence of…