Search results for " import"

showing 10 items of 163 documents

Chemical Proteomics-Guided Identification of a Novel Biological Target of the Bioactive Neolignan Magnolol

2019

Understanding the recognition process between bioactive natural products and their specific cellular receptors is of key importance in the drug discovery process. In this outline, some potential targets of Magnolol, a natural bioactive compound, have been identified by proteomic approaches. Among them, Importin-β1 has been considered as the most relevant one. A direct binding between Magnolol and this nuclear chaperone has been confirmed by DARTS and molecular docking, while its influence on Importin-β1 translocation has been evaluated by in vitro assays.

bioactive neolignans02 engineering and technologyComputational biology010402 general chemistryProteomics01 natural scienceslcsh:Chemistrychemistry.chemical_compoundchemical proteomicsdrug affinity responsive target stabilityOriginal Researchbioactive neolignans; chemical proteomics; drug affinity responsive target stability; molecular docking; nuclear importbiologyChemistryDrug discoveryIn vitro toxicologyGeneral Chemistrymolecular docking021001 nanoscience & nanotechnologynuclear importMagnololBioactive compound0104 chemical sciencesChemistrylcsh:QD1-999Biological targetChaperone (protein)Direct bindingbiology.protein0210 nano-technologyFrontiers in Chemistry
researchProduct

Promoter Activation in Dhfq Mutants as an Efficient Tool for Specialized Metabolite Production Enabling Direct Bioactivity Testing

2019

Abstract Natural products (NPs) from microorganisms have been important sources for discovering new therapeutic and chemical entities. While their corresponding biosynthetic gene clusters (BGCs) can be easily identified by gene‐sequence‐similarity‐based bioinformatics strategies, the actual access to these NPs for structure elucidation and bioactivity testing remains difficult. Deletion of the gene encoding the RNA chaperone, Hfq, results in strains losing the production of most NPs. By exchanging the native promoter of a desired BGC against an inducible promoter in Δhfq mutants, almost exclusive production of the corresponding NP from the targeted BGC in Photorhabdus, Xenorhabdus and Pseud…

bioactivity testingnatural productsMetaboliteMutantPeptide SynthetasesXenorhabdus010402 general chemistry01 natural sciencesCatalysisBiosynthesis | Very Important Paperchemistry.chemical_compoundddc:570RNA chaperoneHumansMetabolomicsGeneResearch ArticlesBiological Productsbiology010405 organic chemistryPseudomonastechnology industry and agricultureGeneral MedicineGeneral Chemistrybiology.organism_classification0104 chemical sciencesBiosynthetic PathwayseasyPACIdchemistryBiochemistryddc:540proteobacteriaPhotorhabdussimplified productionResearch Article
researchProduct

Sport and Quality of Life

2022

Negli ultimi trent’anni lo sport ha assunto un significato molto rilevante nella vita delle persone e, seppure con notevoli differenze, sia nei paesi a sviluppo economico avanzato, sia in quelli in via di sviluppo. A livello individuale, esso ha costituito un’area di investimento identitario quando ha assunto la forma di sport spettacolo del quale fruire, alimentando la pratica del tifo e il fandom o costituendo il modello di uno stile di vita vincente; ma anche quando ha assunto la forma di pratica del tempo libero attraverso la quale tenersi in forma, facendo crescere, in questo caso, la diffusione di una cultura della salute e del benessere. Si tratta di due modalità di approcciare al co…

but also when he took the form of free time practice through which to keep fit making grow in this case the diffusion of a culture of health and well-being. These are two ways of approaching the consumption of sports by spectators and actorIn the last thirty years sport has taken on a very significant meaning in people's lives and albeit with considerable differences both in advanced economic development countries and in developing countries. On an individual level it constituted an area of identity investment when it assumed the shape of “sport spectacle” to be enjoyed fueling the practice of cheering and fandom or constituting the model of a winning lifestyleand the two ways of use can be strongly related to the perception and assessment of the quality of life. The “semantic universes” which however connote sport and “free time sports” have often appeared polarized. Commercial sport and sports professionalism are intertwined with the institutions of economics politics and culture which above all stress its “spectacularity” in order to capture first and foremost the audience. But also the sport of leisure time is intertwined with the actions of the institutions of economics politics and culture with the difference that these stress above all its “healthy value” aimed at the “healthy and rational” investment of time in an activity which improves the quality of life in the short medium and long period. This polarization between the consumption of sport entertainment - commercial sport - and the consumption of sport as a leisure activity - sport for all - has become increasingly interconnected precisely because of the increased collective identity demand via sport. In other words we have witnessed the spread of shape of sports entertainment that recall the importance of sports for psychophysical well-being for integration and social participation for the reduction of social inequalities ethnic and cultural differences and in which the importance assumed was weakened in the show from agonism from competition from the physical confrontation between two contenders or two teams. A sport in which we act with competitors as well as against competitors. And on the other hand we have gradually witnessed the spectacularization of sports in our free time to the point that the sharing of the results obtained through the declination of a competitive spirit that presents itself as directed no longer against other contenders but against its own performance limits it has become the way in which each person makes part of his or her own life spectacular the one he often considers most authentic. The aim of this work is to describe how the intertwining between the commercial/professional dimension of the sports show and the playful/recreational dimension of sports practice are fueled by a demand and an offer of social identity that characterizes these two “semantic universes”.Settore SPS/07 - Sociologia Generale
researchProduct

Importaciones de los siglos VI-V aC en el centro y norte del País Valenciano

2000

En el siguiente trabajo hacemos una aproximación a las cerámicas de filiación griega de época arcaica (siglos VI-V a.C.) llegadas a los poblados ibéricos de la zona Norte y centro del País Valenciano fruto del intercambio comercial entre indígenas y navegantes de origen griego o púnico. Quedan fuera las comarcas meridionales ya que son objeto, en esta misma reunión, de otras dos comunicaciones de esta misma reunión. This paper is an overview about all archaic imports found in north and center of Valencian country. These imports are diverse provenance and it is important to note the greek trade amphoras scarcity, placed along the coast; whereas, the phenico-punic amphoras and the greek table…

cerámica importadaUNESCO::HISTORIA::Historia por épocasUNESCO::HISTORIAcultura ibéricamediterráneo occidental
researchProduct

Engineered Multifunctional Nanotools for Biological Applications

2011

Smart multifunctional magnetic nanoparticles are popular candidates for several biological applications owing to their intrinsic magnetic property and diverse applications that range from rare protein separation and biomedical utilization to cancer therapy and diagnostics. A universal protocol, for the development of such nanocarriers, is highly desirable for scientists with different backgrounds so that custom-made multifunctional nanoparticles can be developed to address their needs, among which are the superparamagnetic iron oxide and manganese oxide nanoparticles that are synthesized through high temperature decomposition reactions. However, an interface is needed to present these inorg…

chemistry.chemical_classificationMaterials scienceFunctional importancechemistryBiomoleculeMultifunctional nanoparticlesCancer therapyTumor therapyMagnetic nanoparticlesNanoparticleNanotechnologyNanocarriers
researchProduct

Reactive Polymers: A Versatile Toolbox for the Immobilization of Functional Molecules on TiO2 Nanoparticles

2006

chemistry.chemical_classificationMaterials sciencechemistryFunctional importanceTio2 nanoparticlesNanotechnologyGeneral ChemistryPolymerGeneral MedicineCatalysisToolboxAngewandte Chemie
researchProduct

Green-Light Activation of Push-Pull Ruthenium(II) Complexes.

2020

Abstract Synthesis, characterization, electrochemistry, and photophysics of homo‐ and heteroleptic ruthenium(II) complexes [Ru(cpmp)2]2+ (22+) and [Ru(cpmp)(ddpd)]2+ (32+) bearing the tridentate ligands 6,2’’‐carboxypyridyl‐2,2’‐methylamine‐pyridyl‐pyridine (cpmp) and N,N’‐dimethyl‐N,N’‐dipyridin‐2‐ylpyridine‐2,6‐diamine (ddpd) are reported. The complexes possess one (32+) or two (22+) electron‐deficient dipyridyl ketone fragments as electron‐accepting sites enabling intraligand charge transfer (ILCT), ligand‐to‐ligand charge transfer (LL'CT) and low‐energy metal‐to‐ligand charge transfer (MLCT) absorptions. The latter peak around 544 nm (green light). Complex 22+ shows 3MLCT phosphorescenc…

chemistry.chemical_elementQuantum yield010402 general chemistryElectrochemistryPhotochemistry01 natural sciencesCatalysisPhotoinduced electron transferchemistry.chemical_compoundPhotochemistry | Very Important PaperluminescenceAcetonitrilerutheniumphotophysicsphotochemistryFull Paper010405 organic chemistryChemistryOrganic ChemistryGeneral ChemistryFull Papers0104 chemical sciencesRutheniumExcited stateLuminescencePhosphorescencephotocatalysisChemistry (Weinheim an der Bergstrasse, Germany)
researchProduct

"IL RUOLO DELLE BANCHE LOCALI NEI PROCESSI DI INTERNAZIONALIZZAZIONE DELLE PMI MARCHIGIANE"

2008

Questo lavoro contiene un'analisi empirica per valutare il grado di diffusione nell'operatività delle banche operanti nella Regione Marche, dei prodotti/servizi finanziari avanzati per facilitare una maggiore visibilità delle PMI nei mercati internazionali. L'analisi delle componenti di offerta è stata effettuata tramite la somministrazione di un questionario di un questionario contenuto in un lavoro precedentemente pubblicato dall’ABI a cura del Prof. Fabrizio Onida che però aveva come oggetto di riferimento non soltanto piccole banche ma anche filiali estere di banche commerciali locali, banche estere, intermediari finanziari non bancari (ad esempio società internazionali di leasing e fac…

corporate banking investment banking commercial banking localismo bancario bonifici esteri in uscita e in entrata assegni finanziamenti import/export crediti documentariSettore SECS-P/11 - Economia Degli Intermediari Finanziari
researchProduct

Diversification Strategy

2013

diversificationdiversification; fundamentals; importanceimportancefundamentalsSettore SECS-P/08 - Economia e Gestione delle Impresefundamental
researchProduct

Wpływ handlu zagranicznego Unii Europejskiej na rzeczywistą emisję CO2

2016

Emisja CO2 jest problemem globalnym. Oznacza to, że walka tylko części krajów w tym obszarze niewiele zmienia. Celem niniejszego artykułu jest próba ukazania rzeczywistego poziomu emisji CO2 w UE, jak również wpływ wymiany handlowej Unii na emisję CO2 u jej głównych partnerów handlowych. Badanie zostało przeprowadzone na grupie 20 głównych partnerów handlowych UE i samej Unii. Rzeczywisty poziom emisji CO2 uzyskano przez zastosowanie wskaźnika emisji rzeczywistej. Jego wielkość uwzględnia transfer CO2 w produktach i usługach eksportowych, a także importowanych przez poszczególne kraje. W wyniku jego zastosowania okazało się, że rzeczywisty poziom emisji CO2 w badanych krajach jest znacznie …

eksport i import UEgłówni partnerzy handlowi UEemisja CO 2EU energy policypolityka energetyczna UECO2 emissionsexports and imports of the EUmain trading partners of the EUEkonomia XXI Wieku
researchProduct