Search results for " import"

An Organometallic Gold(I) Bis‐N‐Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells

2020

Abstract The organometallic AuI bis‐N‐heterocyclic carbene complex [Au(9‐methylcaffeine‐8‐ylidene)2]+ (AuTMX2) was previously shown to selectively and potently stabilise telomeric DNA G‐quadruplex (G4) structures. This study sheds light on the molecular reactivity and mode of action of AuTMX2 in the cellular context using mass spectrometry‐based methods, including shotgun proteomics in A2780 ovarian cancer cells. In contrast to other metal‐based anticancer agents, this organogold compound is less prone to form coordinative bonds with biological nucleophiles and is expected to exert its drug effects mainly by non‐covalent interactions. Global protein expression changes of treated cancer cell…

Studienendpunkte bei der chronisch-obstruktiven Lungenerkrankung (COPD): „Minimal Clinically Important Difference”

2008

The concept of the minimal clinically important difference (MCID) is intended to provide a measure of relevance for a statistically applied in patients with COPD. Clinically important differences are those differences relevant to the individual patient and important to the patient's life. However, people's difference in a diagnostic parameter perception of what is important vary. Furthermore, physicians may rate the significance of a particular marker and its difference which can be achieved by a pharmacological intervention differently from the patient. Thus, the major problem with defining an MCID for any measure is that the most important differences, which require the most subtle measur…

Effects Of Whole Body Vibration In Patients With Chronic Obstructive Pulmonary Disease - A Randomized Controlled Trial

2012

Summary Introduction To date endurance and strength training are established and evidence-based exercise methods in patients with chronic obstructive pulmonary disease (COPD). There is an unmet need for further research in new and complementary exercise modalities. Additional whole body vibration training during pulmonary rehabilitation may be such a new approach that has not yet been investigated in patients with COPD. Methods Eighty-two patients (65 ± 9 yrs, FEV 1 pred. 38 ± 11%, female 51%) with COPD in GOLD stage III to IV assessed for a 3-week inpatient multidisciplinary rehabilitation program were on top randomly assigned to one of two intervention groups: (1) 3 × 3 min of bilateral d…

The Impact of the Poland Foreign Trade On Its Real CO2 Emissions

2017

CO2 emissions are a global problem. This means that nothing or very little will change if only particular countries are involved. The purpose of this paper is the attempt to show the real CO2 emissions of the Poland as well as the impact of its trade on CO2 emissions in other countries in the world and in the EU in 2015. This study was conducted on the group of countries that are the major emitters of CO2 in the world including most of the EU members. Actual CO2 emissions were achieved by applying the actual emission factor. This takes into account the transfer of CO2 in export products and services as well as those imported by particular countries. It has turned out that the real CO2 emiss…

La importancia del actor. Reflexiones sobre el porvenir de la historia social

2021

Cooperation of Two mRNA-Binding Proteins Drives Metabolic Adaptation to Iron Deficiency

2008

Summary Iron (Fe) is an essential cofactor for a wide range of cellular processes. We have previously demonstrated in yeast that Cth2 is expressed during Fe deficiency and promotes degradation of a battery of mRNAs leading to reprogramming of Fe-dependent metabolism and Fe storage. We report here that the Cth2-homologous protein Cth1 is transiently expressed during Fe deprivation and participates in the response to Fe deficiency through the degradation of mRNAs primarily involved in mitochondrially localized activities including respiration and amino acid biosynthesis. In parallel, wild-type cells, but not cth1 Δ cth2 Δ cells, accumulate mRNAs encoding proteins that function in glucose impo…

Heteroaromatic Inhibitors of the Astacin Proteinases Meprin α, Meprin β and Ovastacin Discovered by a Scaffold-Hopping Approach.

2020

Abstract Astacin metalloproteinases, in particular meprins α and β, as well as ovastacin, are emerging drug targets. Drug‐discovery efforts have led to the development of the first potent and selective inhibitors in the last few years. However, the most recent compounds are based on a highly flexible tertiary amine scaffold that could cause metabolic liabilities or decreased potency due to the entropic penalty upon binding to the target. Thus, the aim of this study was to discover novel conformationally constrained scaffolds as starting points for further inhibitor optimization. Shifting from flexible tertiary amines to rigid heteroaromatic cores resulted in a boost in inhibitory activity. …

Hydraulic kinetics of the graft union in different Olea europaea L. scion/rootstock combinations

2007

The hydraulic resistance of young olive trees grafted on rootstocks with contrasting size-controlling potential was measured 30, 90, 360 and 480 days after grafting. Olive (Olea europaea L.) clones inducing plant vigorous growth (Leccino ‘Minerva’, LM) or dwarfing (Leccino ‘Dwarf’, LD) were studied in different scion/rootstock combinations (LD/LD, LD/LM, LM/LD, LM/LM). Plants growing on LD root systems developed lower leaf surface areas (about 50% less) than plants grafted on LM rootstocks. Graft union represented the largest fraction (up to 85%) of whole-plant hydraulic resistance 30 days after grafting, and still represented an important fraction of it 2 months later (40–55%). Four-hundre…

A weighted logistic regression for conjoint analysis and Kansei engineering

2007

Customer needs for emotional satisfaction are increasingly being considered by product and service designers. While several existing methods such as conjoint analysis (CA), Kano model and quality function deployment support the translation of customer requirements into technical specifications, researchers are now working to develop methods aimed at integrating affective aspects into product design. Kansei engineering (KE) is a design philosophy that considers customer perceptions and emotions by adopting a multi-disciplinary approach. CA is a useful tool within a KE project. This article presents a methodology for conducting a KE project in early development phases. This methodology is bas…

Prime liste faunistiche di Lepidotteri diurni in aree protette italiane

2014

Nell’ambito del progetto Life+ 2008, Validation of risk management tools for genetically modified plants in protected and sensitive areas in Italy (MAN-GMP-ITA), sono stati condotti studi di caratterizzazione dell’entomofauna di alcune aree protette in Italia, da marzo a settembre di due anni consecutivi (2011-2012). Tali studi hanno condotto alla redazione di liste faunistiche di Lepidotteri diurni, Lepidotteri notturni e Coccinellidi per ciascun sito. I due gruppi di specie sono stati scelti in considerazione del loro possibile ruolo come specie “non-target” in studi di impatto ambientale. Le aree oggetto di studio sono state scelte in modo da essere rappresentative di diverse aree bio-ge…