Search results for " in vivo"
showing 10 items of 32 documents
Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C.
2004
Background: Cactus pear (Opuntia ficus-indica) fruit contains vitamin C and characteristic betalain pigments, the radical-scavenging properties and antioxidant activities of which have been shown in vitro. Objective: We investigated the effects of short-term supplementation with cactus pear fruit compared with vitamin C alone on total-body oxidative status in healthy humans. Design: In a randomized, crossover, double-treatment study, 18 healthy volunteers received either 250 g fresh fruit pulp or 75 mg vitamin C twice daily for 2 wk, with a 6-wk washout period between the treatments. Before (baseline) and after each treatment, 8-epiprostaglandin F2α (8-epi-PGF2α) and malondialdehyde in plas…
Antioxidative effects of cactus pear (Opuntia ficus indica, L. Mill.) fruits from Sicily and bioavailability of betalain components in healthy humans
2009
Aerobic life is characterised by a steady formation of pro-oxidants, which is approximately balanced by antioxidant defense systems. When cell’s capacity to protect itself fails, oxidative stress occurs. Because of bioactive components vegetables are now considered helpful in preventing chronic pathologies in which oxidative damage is an important etiologic factor. Cactus pear (Opuntia ficus-indica) fruit contains substantial amounts of vitamin C, biothiols, and taurine, and redox-active betalain pigments. It has been shown that a short-term supplementation (500 g fruit pulp daily, 2 wk) positively affected the body’s redox balance, decreased lipid oxidation, and improved antioxidant status…
Influence of Different Rehydration Protocols on Biomechanical Properties of Allogeneic Cortical Bone Plates: A Combined in-vitro/in-vivo Study
2020
Introduction: Allogeneic cortical bone plates (CP) are used for alveolar ridge augmentation. Since CP are freeze-dried and dehydrated during processing, the breaking strength (BS) and the flexibility (FX) are reduced, resulting in a relevant risk for plate fractures during insertion. The aim of this study was to evaluate the influence of rehydration time on the biomechanical properties (BS & FX) of CP in-vitro and in vivo.Material and Methods: 40 CP were randomly divided into four experimental groups. (A) untreated control (n = 10), rehydration for 10 (B), 30 (C) and 60 (D) minutes in 0.9% saline solution (n = 10 each). BS [Newton, N] and FX [mm] (force till fracture and distance of deflect…
Dosimetría en ginecología y verificación de tratamientos en braquiterapia electrónica
2021
Dosimetría en ginecología y verificación de tratamientos en braquiterapia electrónica, trata de valorar y discutir los valores de dosis absorbida en diferentes aplicaciones clínicas de la braquiterapia electrónica. La fuente utilizada en estos sitemas consiste en un tubo de vacío de 10 mm de longitud y de 2 mm de diámetro encerrado en un catéter de refrigeración de 5,6 mm de diámetro, suele funcionar a 50kVp. En concreto se centra en los tratamientos ginecológicos de cáncer de endometrio y cáncer de cérvix cérvix, donde se presentan los primeros resultados clínicos obtenidos, además de compararlos con los que se hubieran obtenido caso de realizar los tratamientos con equipos de braquiterapi…
In-vitro and In-vivo study results, what tells what?
2013
Chronic neural probe for simultaneous recording of single-unit, multi-unit, and local field potential activity from multiple brain sites
2017
Drug resistant focal epilepsy can be treated by resecting the epileptic focus requiring a precise focus localisation using stereoelectroencephalography (SEEG) probes. As commercial SEEG probes offer only a limited spatial resolution, probes of higher channel count and design freedom enabling the incorporation of macro and microelectrodes would help increasing spatial resolution and thus open new perspectives for investigating mechanisms underlying focal epilepsy and its treatment. This work describes a new fabrication process for SEEG probes with materials and dimensions similar to clinical probes enabling recording single neuron activity at high spatial resolution.Polyimide is used as a bi…
Innovative ultrasound systems for preclinical studies: design and production of new instruments and set-ups for in vitro and in vivo experiments – Si…
Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function.
2009
The impact of serotonergic neurotransmission on brain dopaminergic pathways has substantial relevance to many neuropsychiatric disorders. A particularly prominent role has been ascribed to the inhibitory effects of serotonin 2C receptor (5-HT2CR) activation on physiology and behavior mediated by the mesolimbic dopaminergic pathway, particularly in the terminal region of the nucleus accumbens. The influence of this receptor subtype on functions mediated by the nigrostriatal dopaminergic pathway is less clear. Here we report that a null mutation eliminating expression of 5-HT2CRs produces marked alterations in the activity and functional output of this pathway. 5-HT2CR mutant mice displayed i…
NANO-EMETTITORI NIR A BASE DI SILICE PER APPLICAZIONI IN-VIVO E RELATIVO PROCESSO DI PRODUZIONE
2010
Realizzazione di nano-sonde paramagnetiche e fosforescenti, ottenibili a partire da particelle nanometriche di silice mediante procedure di sintesi e arricchimento di O2 a seguito di opportuni trattamenti termici in ambiente controllato. Le nano-sonde così ottenute presentano emissioni nel vicino infrarosso (NIR), sono eccitabili nel visibile e nel NIR, e sono caratterizzate da un tempo di vita nell’ordine del secondo. Tali nano-sonde presentano un notevole potenziale scientifico e commerciale nel mercato della spettroscopia confocale per bio-imaging e nel mercato delle applicazioni medico-farmaceutiche di drug-labelling e drug-delivery.
Effetti dell’applicazione in post emergenza degli oli essenziali di eucalipto sulle piante infestanti e sulla comunità microbica del suolo
2017
L'uso diffuso di erbicidi sintetici ha un impatto negativo sulla salute umana e sull’ecosistema. Per il superamento di questi problemi, si stanno valutando soluzioni alternative per ridurre l’utilizzo di erbicidi sintetici. Molti studi hanno dimostrato che gli oli essenziali (EO) estratti da alcune piante hanno un'attività erbicida. Gli EO, sono costituiti da composti organici volatili e caratterizzati da un forte odore; vengono utilizzati dalle industrie cosmetiche, farmaceutiche e alimentari in quanto sono considerati composti sicuri per l’uomo, gli animali e l'ambiente. Diversi studi hanno dimostrato che gli EO estratti dalle foglie di eucalipto hanno effetti antimicrobici, antivirali, f…