Search results for " injury"
showing 10 items of 1007 documents
Kompensācija cietušajam par nodarīto kaitējumu kriminālprocesā
2015
Mūsdienās aizvien ir aktuāla morālā kaitējuma kompensācijas noteikšana kriminālprocesā, it sevišķi tāpēc, ka morālam kaitējumam nepastāv precīzi nosakāms naudas ekvivalents. Darba mērķis ir izveidot universālu, ilgspējīgu morālā kaitējuma noteikšanas koncepciju, skaidri noteikt kritērijus, kuri tiesnešiem jāņem vērā, lemjot par kaitējuma kompensācijas apmēru, turklāt izpētīt arī praktiskos jautājumus, kas saistās ar kompensācijas pieteikšanu. Pētījuma rezultātā izstrādāta ilgspējīga morālā kaitējuma koncepcija, kurā noteikti rekomendējoši, taču aptuveni kompensācijas piešķiršanas apmēri, kā arī piedāvāti vairāki Kriminālprocesa likuma grozījumi.
Exercise as therapy for neurodevelopmental and cognitive dysfunction in people with a Fontan circulation: A narrative review
2023
People with a Fontan circulation are at risk of neurodevelopmental delay and disability, and cognitive dysfunction, that has significant implications for academic and occupational attainment, psychosocial functioning, and overall quality of life. Interventions for improving these outcomes are lacking. This review article discusses current intervention practices and explores the evidence supporting exercise as a potential intervention for improving cognitive functioning in people living with a Fontan circulation. Proposed pathophysiological mechanisms underpinning these associations are discussed in the context of Fontan physiology and avenues for future research are recommended.
Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Ag…
2019
Perinatal brain injury (PBI) leads to neurological disabilities throughout life, from motor deficits, cognitive limitations to severe cerebral palsy. Yet, perinatal brain damage has limited therapeutic outcomes. Besides, the immature brain of premature children is at increased risk of hypoxic/ischemic (HI) injury, with males being more susceptible to it and less responsive to protective/therapeutical interventions. Here, we model in male and female C57BL/6 mice, the impact of neonatal HI and the protective effects of neonatal handling (NH), an early life tactile and proprioceptive sensory stimulation. From postnatal day 1 (PND1, modeling pre-term) to PND21 randomized litters received either…
Effects of electrical stimulation pattern on quadriceps isometric force and fatigue in individuals with spinal cord injury
2015
Introduction Variable frequency trains (VFT) or train combinations have been suggested as useful strategies to offset the rapid fatigue induced by constant frequency trains (CFT) during electrical stimulation. However, most studies have been of short duration with limited functional application in those with spinal cord injury (SCI). We therefore tested force and fatigue in response to VFT, CFT, and combined patterns in strength training-like conditions (6-s contractions). Methods Ten SCI individuals underwent either CFT or VFT patterns until target torque was no longer produced and then switched immediately to the other pattern. Results Target torque was reached more times when VFT was use…
Cortical gene expression in spinal cord injury and repair: insight into the functional complexity of the neural regeneration program
2011
Traumatic spinal cord injury (SCI) results in the formation of a fibrous scar acting as a growth barrier for regenerating axons at the lesion site. We have previously shown (Klapka et al., 2005) that transient suppression of the inhibitory lesion scar in rat spinal cord leads to long distance axon regeneration, retrograde rescue of axotomized cortical motoneurons, and improvement of locomotor function. Here we applied a systemic approach to investigate for the first time specific and dynamic alterations in the cortical gene expression profile following both thoracic SCI and regeneration-promoting anti-scarring treatment (AST). In order to monitor cortical gene expression we carried out micr…
Management of Acute Kidney Injury and Extracorporeal Blood Purification Therapies During the COVID-19 Pandemic: The Italian SIN–SIAARTI Joint Survey …
2022
Background and AimThe novel coronavirus disease 2019 remains challenging. A large number of hospitalized patients are at a high risk of developing AKI. For this reason, we conducted a nationwide survey to assess the incidence and management of AKI in critically ill patients affected by the SARS-CoV-2 infection.MethodsThis is a multicenter, observational, nationwide online survey, involving the Italian Society of Nephrology and the critical care units in Italy, developed in partnership between the scientific societies such as SIN and SIAARTI. Invitations to participate were distributed through emails and social networks. Data were collected for a period of 1 week during the COVID-19 pandemic…
Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen
2022
Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered 8 h after overdose to be efficient. Ammonia homeostasis is altered during liver diseases and, during DILI, it is accompanied by decreased glycine N-methyltransferase (GNMT) expression and S-adenosylmethionine (AdoMet) levels that suggest a reduced methionine cycle. Anti-miR-873-5p treatment prevents cell death in primary hepatocytes and the appearance of necrotic areas in liver from APAP-adminis…
Experimental validation of the prosthetic leg
2020
Abstract Studies of populations whose ability to perform voluntary movements is impaired due to natural reasons (e.g. aging), genetic anomaly (e.g. Down syndrome), trauma (e.g. spinal cord injury, amputation) or illness (e.g. Parkinson’s disease) frequently result in a basic question: are the observed motor patterns, which may be rather different from those seen in the general population, actually abnormal? In other words, should they be corrected? This question is important, not only for understanding the mechanisms of control over normal and disordered movements, but also for assessing the effectiveness of existing therapeutic approaches and providing focus for developing new therapies an…
Considerations regarding the alleged association between Herbalife products and cases of hepatotoxicity: a rebuttal.
2014
We thank Dr. K Appelhans et al. for their comments [1] on our paper [2], published online first in April 2012. In our review, we aimed to draw the attention of physicians to the uncontrolled and increasingly alarming use of herbal products and dietary supplements in the general population. In fact, in Italy this phenomenon, though still limited, has rapidly increased over the last few years. Here, use of herbal medicine products has increased to 3.7 %, while in other countries consumption is higher, reaching 20 % in the UK, and 40 % in the USA. Young non-smoking women with a high level of education appear to be the most common consumers [3]. It seems that women use these products more than …
Learning Curve in Surgical Treatment of Odontoid Fixation for a Series of Type II C2 Fractures
2019
The craniovertebral junction (CVJ) is a complex anatomical area upon which most of the motion of the upper cervical spine depends [1]. Because of its unique range of motion, the CVJ is subject to several types of traumatic injury; it has been shown that odontoid fractures are the most common ones in the general population and are the most common isolated spinal fractures [2]. Accounting for up to 18% of all cervical fractures, odontoid fractures are the most common ones in elderly patients [3], in whom they account for up to 60% of spinal cord injuries [4].