Search results for " injury"

P4613Long-term impact of postnatal nutritional programming on cardiac sensitivity to ischemia-reperfusion injury in vivo and on cardio-protective pat…

2019

Abstract Introduction Nutritional disturbances during the postnatal period may be responsible for a predisposition, or “programming”, to increased cardio-metabolic risk and to a progressive alteration of left ventricular contractility in adulthood. This nutritional perinatal programming may also lead to an alteration of cellular pathways involved in cardiac protection, such as the specific RISK and SAFE pathways, highlighted during pre- and post-ischemic conditioning or those of sirtuins (SIRT), histone deacetylases involved in the regulation of essential biological process. Purpose Our aim was to evaluate in mice the impact of postnatal overfeeding (PNOF) on cardiac sensitivity to ischemia…

Die laterale Dissektion des Mesorektums ; ein Risiko für den Plexus hypogastricus inferior

2004

Lateral mesorectal dissection may injure parasympathetic and sympathetic pelvic nerves and a partial or complete lesion of the autonomic pelvic nerves leads to urogenital dysfunctions affecting patient’s quality of life after rectum resection for rectal carcinoma. The aim of the present prospective study was to clarify the significance for nerve damage during lateral dissection based on standardized assessment parameters. 15 Patients underwent total mesorectal excision for rectal carcinoma (UICC I/II/III/IV: 1/5/3/6). Within the scope of the stanardized intraoperative data collection it was demonstrated, whether a complete preservation of the autonomie pelvic nerves was successful. In 11 pa…

Head Injury Criterion: mini review

2019

Head Injury Criterion (HIC) is the most important parameter in terms of human survival; it is indicative of brain injuries due to the impact of the head in numerous cases, with a vehicle. This index can be estimated by integrating the resulting acceleration of the head (measured in its gravity center) in a time window

Ungewöhnlicher Verlauf von otobasalen Frakturen mit Liquorrhoe*

1993

In the literature the persistence of cerebrospinal Liquorrhea after temporal bone fractures is a rare event. Between 1989 and 1992 four cases of temporal bone fractures with dural involvement were operated at the University ENT Department Mainz. These temporal bone fractures showed delayed or persistent symptoms of dural lacerations between three and sixty months after head injury. During operation we found larger bone-dura defects (1-1.5 cm in diameter) and brain herniations in all cases. Strohm stated that only in rare cases a temporal bone fracture produced a larger gap in the tegmen tympani or antri. Therefore, we assumed that in our cases such larger bone-dura defects were caused by a …

Hepatitis C virus infection and global kidney health: the consensus proceedings of the International Federation of Kidney Foundations

2020

Hepatitis C virus (HCV) infection is an important cause of major morbidities including chronic liver disease, liver cancer, and acute kidney injury (AKI) as well as chronic kidney disease (CKD). HCV can affect kidney health; among CKD and AKI patients with HCV infection, the clinical outcomes are worse. The prevalence of HCV infection is exceptionally high among dialysis and kidney transplant patients throughout the globe. It is estimated that 5% to 25% or more of dialysis dependent patients are affected by chronic HCV, based on the region of the world. Almost half of all deaths in CKD patients, including HCV-infected patients, are due to cardiovascular disease, and HCV infected patients ha…

Role of Ischemia/Reperfusion Injury in Organ Transplantation

1997

Reperfusion of oxygenated blood into previously ischemic tissue is essential to prevent the progression of cellular injury due to the decreased nutritional blood flow, i.e., the decreased delivery of oxygen and metabolic substrates, as well as the removal of harmful metabolic byproducts. However, it has become obvious that reperfusion also initiates a complex series of pathologic events that contribute to, rather than prevent, further tissue damage. Moreover, a growing body of evidence indicates that ischemia/reperfusion injury is initiated by events that occur at the level of the microcirculation. In the first part of this overview, we will delineate the major components of the microcircul…

P1742Experimental ischemic stroke in rats induce myocardial contractile dysfunction in vivo and ex vivo and increase cardiac vulnerability to ischemi…

2017

Evaluation of the effectiveness of occupational injury prevention programs at the company level

2013

The objective was to evaluate the effectiveness of an occupational injury prevention program, known as the Preferential Action Plan (PAP), focused on companies with high incidence rates of occupational injuries. We studied 1189 companies in the industrial, construction and services sectors between 1999 and 2007 in the Valencia region (Spain). Our sample included 507,262 workers, among whom 44,250 non-fatal occupational injuries with at least a workday lost were registered. Companies included in a PAP program were divided into three intervention groups, according to the year that each company entered into a PAP (2000, 2001, and 2002). We calculated annual percentage change in incidence rates…

Emergent and delayed hybrid external fixation management of tibial pilon fractures: A multicentric retrospective analysis of 80 patients

2017

Objective: To report our experience with the hybrid external fixator in emergency. Methods: We assessed 80 cases of pilon fracture treated with the external fixator during the period of January 2009 and December 2016:55 men (69%) and 30 women (33%) with a mean age of 40 years (range between 16 and 70). About 45 occurred as isolated trauma, 35 instead were politrauma. Each patient underwent standard radiographic examination and a CT examination. There were 28 open fractures (35%), (Gustilo type 1, 2 and 3) while closed fractures showed soft tissue involvement of various grade (2-3 Tscherne classification). In all cases, the external fixation, sometimes associated with other reduction and syn…

<title>Near-infrared spectroscopy (NIRS) as a diagnostic tool in patients with suspected stroke or traumatic brain injury</title>

2001

Near-Infrared Spectroscopy (NIRS) as a diagnostic tool in patients with suspected stroke or brain injury S. Goldberg, C. Lott, M. Ostermeyer, H.-J. Hennes Absorption of Near-Infrared (NIR) light in the brain is mainly caused by hemoglobin. Superficial intracranial hematoma with a higher concentration of hemoglobin causes a higher absorption in NIRS. The existence of hemorrhage can be demonstrated by the difference of optical density, comparing identical measuring points at both hemispheres of the brain: absorption of NIR light is greater at the side of the hemorrhage, causing less reflection in NIRS. In a prospective, blinded study, 100 patients who were scheduled for CCT-scan for brain inj…