Search results for " insertion"
showing 10 items of 89 documents
Insertion of isocyanides into the 2-one-1-propyl—palladium(II) bond: A convenient synthetic route to C1-palladated 1-amino-3-one-1-butene compounds
1984
Abstract Migratory insertion of isocyanides CNR (R = p -C 6 H 4 OMe, Me) into the palladium—carbon σ bond of trans -[PdCl(CH 2 COMe)(PPh 3 ) 2 ] (I) yields the 1-amino-3-one-1-butenyl complexes trans -[PdCl{C(NHR)CHCOMe}(PPh 3 ) 2 ] (IIa, R = p -C 6 H 4 OMe; IIb, R = Me), which have been characterized by IR, 1 H and 31 P NMR spectra. The reaction of IIa with nickel acetate gives a diamagnetic bischelate complex of the type [Ni(ON) 2 ] , in which the deprotonated 1-amino-3-one-1-butenyl moiety acts as a bidentate O,N ligand.
Multiple Roles of Isocyanides in Palladium-Catalyzed Imidoylative Couplings: A Mechanistic Study
2016
International audience; Kinetic, spectroscopic and computational studies examining a palladium-catalyzed imidoylative coupling highlight the dual role of isocyanides as both substrates and ligands for this class of transformations. The synthesis of secondary amides from aryl halides and water is presented as a case study. The kinetics of the oxidative addition of ArI with RNC-ligated Pd-0 species have been studied and the resulting imidoyl complex [(ArC=NR)Pd(CNR)(2)I] (Ar=4-F-C6H4, R = tBu) has been isolated and characterized by X-ray diffraction. The unprecedented ability of this RNC-ligated imidoyl-Pd complex to undergo reductive elimination at room temperature to give the amide in the p…
Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin α-H2A Histone Gene
2007
The tandemly repeated sea urchin alpha-histone genes are developmentally regulated. These genes are transcribed up to the early blastula stage and permanently silenced as the embryos approach gastrulation. As previously described, expression of the alpha-H2A gene depends on the binding of the MBF-1 activator to the 5' enhancer, while down-regulation relies on the functional interaction between the 3' sns 5 insulator and the GA repeats located upstream of the enhancer. As persistent MBF-1 binding and enhancer activity are detected in gastrula embryos, we have studied the molecular mechanisms that prevent the bound MBF-1 from trans-activating the H2A promoter at this stage of development. Her…
Contingency factors on the success of services for social integration and job placement schemes
2009
The success of a strategy depends, to a large extent, on the contingency factors that condition the functioning of an organisation. This study presents empirical research to contrast the existence of a significant relationship between the implementation of a particular strategy (in this case, related to the management of job placement and social insertion schemes) and a set of given structural parameters or contingency factors, in particular, the organisational structure of the firm such as time with the firm, firm size, technology used and organisational culture. The empirical analysis is applied to the strategies used by local development and employment officers with regard to the managem…
L'insertion professionnelle des diplômés DNSEP 2003 : Enquête nationale 30 mois après le diplôme
2006
Cette enquête qui s'appuie sur une promotion nationale de diplômés du cycle long des écoles supérieures d'art, est la première étude réalisée sur le sujet depuis vingt ans. Elle porte sur l'ensemble d'une promotion de diplômés titulaires du DNSEP (Diplôme national supérieur d́expression plastique) 2003. Elle intervient 30 mois après l'obtention du diplôme en juin 2003.
Les Diplômés DNSEP 2003 : Enquête nationale sur le parcours d'insertion professionnelle
2005
Cette enquête qui s'appuie sur une promotion nationale de diplômés du cycle long des écoles supérieures d'art, est la première étude réalisée sur le sujet depuis vingt ans. Elle porte sur l'ensemble d'une promotion de diplômés titulaires du DNSEP (Diplôme national supérieur d´expression plastique) 2003. Elle intervient 18 mois après l'obtention du diplôme en juin 2003. L'observation au moment de l'enquête aussi bien que les courbes d'évolution, expriment le même constat : le processus d'insertion n'est pas clos à 18 mois, il est au contraire pleinement actif.
L'insertion professionnelle des diplômés DNSEP 2003 trois ans après le diplôme. Enquête flash à 36 mois : Rapport pour le ministère de la Culture et …
2006
06060 - Un résumé en 7 pages est également disponible; Rapport; Cette enquête qui s'appuie sur une promotion nationale de diplômés du cycle long des écoles supérieures d'art, est la première étude réalisée sur le sujet depuis vingt ans. Elle porte sur l'ensemble d'une promotion de diplômés titulaires du DNSEP (Diplôme national supérieur d´expression plastique) 2003. Elle intervient 36 mois après l'obtention du diplôme en juin 2003.
Palliative Treatment of Dyspnea With Epidural Methadone in Advanced Emphysema
2005
This study investigated whether epidural methadone perfusion at the thoracic level can mitigate dyspnea in patients with advanced emphysema.Open-label clinical trial without a control group.University hospital.The inclusion criteria were a diagnosis of emphysema, basal dyspnea index (Mahler scale)or = 3, FEV(1)or = 35%, and no indication for pneumoreduction or lung transplantation surgery.An epidural catheter was inserted at the thoracic level connected to a perfusion pump for administering methadone (6 mg/24 h). Assessments were made at baseline, 1 week, and 1 month after catheter insertion.Pulmonary function tests were performed, and determinations were made of arterial blood gas levels, …
The Third Competition for Ernesto Basile’s Palace of Justice. Analysis, Conjectural Reconstruction and Photo Insertions
2022
The competition for the Palazzo di Giustizia in Rome takes place in four phases that develop between 1884 and 1887. The project of the third competition (1886-1887), drawn up by Ernesto Basile (Palermo 1857-1932), reveals a great maturity design that transforms the complex functional program into a rigorous neo-Renaissance style building. The jury recognizes the quality of the project and selects it for the final phase by invitation (1887) together with that one of Guglielmo Calderini, who will be the winner. The original drawings of the unrealized work are kept at the Basile Endowment of the Department of Architecture of the University of Palermo: among them there are sketches, preparatory…
Oligomerization and hemolytic properties of the C-terminal domain of pyolysin, a cholesterol-dependent cytolysin
2013
Pyolysin (PLO) belongs to the homologous family of the cholesterol- dependent cytolysins (CDCs), which bind to cell membranes containing cholesterol to form oligomeric pores of large size. The CDC monomer structure consists of 4 domains. Among these, the C-terminal domain 4 has been implicated in membrane binding of the monomer, while the subsequent processes of oligomerization and membrane insertion have primarily been assigned to other domains of the molecule. Recombinantly expressed or proteolytic fragments that span domain 4 of the CDCs streptolysin O and perfringolysin O bind to membranes but fail to oligomerize, and they inhibit the activity of the respective wild-type toxins. We repo…