Search results for " integrity"
showing 10 items of 126 documents
Latest Frontier Technology and Design of the ATLAS Calorimeter Trigger Board Dedicated to Jet Identification for the LHC Run 3
2016
To cope with the enhanced luminosity of the beam delivered by the Large Hadron Collider (LHC) in 2020, the “A Toroidal LHC ApparatuS” (ATLAS) experiment has planned a major upgrade. As part of this, the trigger at Level1 based on calorimeter data will be upgraded to exploit fine-granularity readout using a new system of Feature Extractors, which each use different physics objects for the trigger selection. The article focusses on the jet Feature EXtractor (jFEX) prototype, one of the three types of Feature Extractors. Up to 2 TB/s have to be processed to provide jet identification (including large area jets) and measurements of global variables within few hundred nanoseconds latency budget.…
Design and testing of the high speed signal densely populated ATLAS calorimeter trigger board dedicate to jet identification
2017
Abstract—The ATLAS experiment has planned a major upgrade in view of the enhanced luminosity of the beam delivered by the Large Hadron Collider (LHC) in 2021. As part of this, the trigger at Level-1 based on calorimeter data will be upgraded to exploit fine-granularity readout using a new system of Feature Extractors (three in total), which each uses different physics objects for the trigger selection. The contribution focusses on the jet Feature EXtractor (jFEX) prototype. Up to a data volume of 2 TB/s has to be processed to provide jet identification (including large area jets) and measurements of global variables within few hundred nanoseconds latency budget. Such requirements translate …
Development of an optical link card for the upgrade phase II of TileCal experiment
2010
This work presents the design of an optical link card developed in the frame of the R&D activities for the phase 2 upgrade of the TileCal experiment as part of the evaluation of different technologies for the final choice in the next two years. The board is designed as a mezzanine which can work independently or plugged in the Optical Multiplexer Board of the TileCal backend electronics. It includes two SNAP 12 optical connectors able to transmit and receive up to 75 Gbps and one SFP optical connector for lower speeds and compatibility with existing hardware as the Read Out Driver. All processing is done in a Stratix II GX FPGA. Details are given on the hardware design including signal and …
The Loss of Structural Integrity in Damaged Spruce Needles from Locations Exposed to Air Pollution I. Mesophyll and Central Cylinder
1990
In connection with the new type of forest damage, the individual disease situation of two-year-old spruce (Picea abies) needles was analyzed histopathologically in forest areas exposed to different levels of O3-, SO2- and NO3- pollution. Early damage results from losses of chlorophyll in the mesophyll cells. The bleaching is more intensive towards the apex in severely damaged needles. The cytoplasm is aggregated at the cell wall and the chloroplasts show definite structural damage as well. The mesophyll cells below the epidermis, or the cells adjacent to the vascular bundle sheath, appear to be particularly susceptible. Collapsed cells (bone cells), which increase in number with damage, can…
Refitting of an eco-friendly sailing yacht: numerical prediction and experimental validation
2016
A 4.60 m sailing yacht, made with a flax fiber composite and wood, has been refitted with the aim of hull weight reduction and performance improvement during regattas. The first objective was obtained with a lightening of internal hull reinforcements while the second one with a reduction of the maximum beam, in order to minimize the longitudinal moment of inertia. The refitting was first simulated via CAD-FEM interaction to establish the feasibility of the procedure and to verify the structural integrity. The resulting hull was then instrumented with strain gauges and tested under typical rigging and sailing conditions. Results obtained by the numerical modeling and measured from experiment…
H-KPP : Hypervisor-Assisted Kernel Patch Protection
2022
We present H-KPP, hypervisor-based protection for kernel code and data structures. H-KPP prevents the execution of unauthorized code in kernel mode. In addition, H-KPP protects certain object fields from malicious modifications. H-KPP can protect modern kernels equipped with BPF facilities and loadable kernel modules. H-KPP does not require modifying or recompiling the kernel. Unlike many other systems, H-KPP is based on a thin hypervisor and includes a novel SLAT switching mechanism, which allows H-KPP to achieve very low (≈6%) performance overhead compared to baseline Linux.
Internal audit professional principles and academic literature over the last decade: is there a gap to bridge
2022
The Institute of Internal Auditors (IIA) has defined the ethical principles internal auditors must adhere to, allowing them to create a common understanding of ethical behaviour within their profession, thereby promoting ethical culture. This paper aims to analyse the role of these principles in the main branches of internal audit research over the last decade. We examine the most important articles published in this field and categorise them into seven main strands. We assess the extent to which these strands focus on the IIA ethical principles, aiming to identify research gaps in the extant literature. Our findings show that the literature dealing with ethical principles in the recruitmen…
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
2020
AbstractThe accumulation of mutations is frequently associated with alterations in gene function leading to the onset of diseases, including cancer. Aiming to find novel genes that contribute to the stability of the genome, we screened the Saccharomyces cerevisiae deletion collection for increased mutator phenotypes. Among the identified genes, we discovered MET7, which encodes folylpolyglutamate synthetase (FPGS), an enzyme that facilitates several folate-dependent reactions including the synthesis of purines, thymidylate (dTMP) and DNA methylation. Here, we found that Met7-deficient strains show elevated mutation rates, but also increased levels of endogenous DNA damage resulting in gross…
Modulation of base excision repair of 8-oxoguanine by the nucleotide sequence.
2013
8-Oxoguanine (8-oxoG) is a major product of oxidative DNA damage, which induces replication errors and interferes with transcription. By varying the position of single 8-oxoG in a functional gene and manipulating the nucleotide sequence surrounding the lesion, we found that the degree of transcriptional inhibition is independent of the distance from the transcription start or the localization within the transcribed or the non-transcribed DNA strand. However, it is strongly dependent on the sequence context and also proportional to cellular expression of 8-oxoguanine DNA glycosylase (OGG1)-demonstrating that transcriptional arrest does not take place at unrepaired 8-oxoG and proving a causal…
Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine.
2016
DNA damage can significantly modulate expression of the affected genes either by direct structural interference with transcription components or as a collateral outcome of cellular repair attempts. Thus, DNA glycosylases of the base excision repair (BER) pathway have been implicated in negative transcriptional response to several spontaneously generated DNA base modifications, including a common oxidative DNA base modification 8-oxoguanine (8-oxoG). Here, we report that single 8-oxoG situated in the non-transcribed DNA strand of a reporter gene has a pronounced negative effect on transcription, driven by promoters of various strength and with different structural properties, including viral…