Search results for " investigation"

Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspecti…

2021

International audience; Extracellular vesicles (EV) are emergent therapeutic effectors that have reached clinical trial investigation. To translate EV-based therapeutic to clinic, the challenge is to demonstrate quality, safety, and efficacy, as required for any medicinal product. EV research translation into medicinal products is an exciting and challenging perspective. Recent papers, provide important guidance on regulatory aspects of pharmaceutical development, defining EVs for therapeutic applications and critical considerations for the development of potency tests. In addition, the ISEV Task Force on Regulatory Affairs and Clinical Use of EV-based Therapeutics as well as the Exosomes C…

Structural properties of the range-II- and range-III order in amorphous-SiO2 probed by electron paramagnetic resonance and Raman spectroscopy

2010

In the present work we report an experimental investigation by electron paramagnetic resonance spectroscopy on the hyperfine structure of the E. point defect, probing the local arrangement of the network (range-II order), and by Raman spectroscopy on the D 1 and D 2 lines, probing mean features of the network (range-III order). Our studies, performed on a-SiO 2 samples thermally treated at 1000 °C in air for different time durations, show that changes of the hyperfine structure and of the D 1 and D 2 lines occur in a correlated way. These results give strong evidence that the range-II and range-III order properties are intimately related to each other and that these properties are determine…

Role of diagnostic surveys in the conservation of the former mother-church of Santa Margherita di Belice in Sicily: preliminary tests and restoration…

2013

The paper presents the results of a campaign of non-destructive and minimally invasive tests that were conducted in the former mother church of Santa Margherita di Belice (Agrigento, Sicily), damaged during the earthquake in 1968 and now re-used as a “Museum of Memory”. It includes a summary of the refl ections that arose during the preliminary surveys and instrumental tests, and reasons that supported the choice of investigations to be performed and methods to be specifi cally applied for the conservation of the architectural heritage. An innovative method designed to produce an effective diagnosis for the localization of defects and the choice of restoration techniques has been applied: i…

NOVEL PROCESSES FOR THE MODIFICATION AND THE STERILIZATION OF MACROMOLECULAR MATRICES

Epiphysäre Dysplasie des Hüftgelenks, Diagnostik und Differentialdiagnostik mit der MRT

1992

Sixteen hip joints of eight patients with multiple epiphyseal dysplasia were examined by clinical investigation, plain films and by magnetic resonance imaging (MRI), using T1- and T2-weighted images and gradient echoes. MRI is useful in demonstrating the congruity of the joint, in the changes of the epiphyseal signal intensities and the epiphyseal line. Individual changes of the signal intensity patterns on T1- and T2-weighted scans are described. Although MRI exhibits a variety of patterns in different patients, a clearcut differentiation from Legg-Calve-Perthes' disease is possible.

SEA WATER TEMPERATURE RECORDS GATHERED DURING EXPERIMENTAL BOTTOM TRAWL SURVEYS IN THE STRAIT OF SICILY (MEDITERRANEAN SEA)

2009

Depth and sea water temperature values recorded by a Minilog system during several bottom trawl surveys carried out in the Strait of Sicily (Central Mediterranean Sea) in spring (MEDITS) and late summer (GRUND), were analyzed by using an ad hoc developed software (MiSeAT). Depth and temperature profiles were analyzed for each haul. Three sea water temperature (t°C) values were considered: the upper and lower water layers temperature, and the difference between them. Mean values by depth stratum and the corresponding standard deviations were estimated for the three parameters, then compared between the two seasons. Haul parameters recorded during the more heterogeneous GRUND surveys (due to …

Apis mellifera sicula Montagano Polymorphism investigation by molecular methods.

2006

Il caglio in pasta utilizzato per la produzione di formaggi tradizionali siciliani: indagine microbiologica

2014

Vastedda della valle del Belìce cheese: production and microbiological investigation

2007

DNA analysis as tool for identification of bacteria in archaeological watellogged wood

2014

S32. Wooden artifacts: from wood identification to dating and conservation/restoration strategies DNA analysis as tool for identification of bacteria in archaeological waterlogged wood Palla, Franco; University of Palermo; Palermo; Italy Barresi, Giovanna; University of Palermo; Palermo; Italy Di Carlo, Enza; University of Palermo; Palermo; Italy In this work molecular techniques were applied in order to integrate the results obtained by Optical (OM) and Scanning Electron (SEM) Microscopy, to understanding and assessing the changes in the anatomical structure of archaeological waterlogged wood (Pinus sp.) induced by bacteria colonization. Observation of wooden thin sections by OM showed the…