Search results for " jun"
showing 10 items of 611 documents
Correction: Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells
2021
High levels of circulating heat shock protein 70 (HSP70) are detected in many cancers. In order to explore the effects of extracellular HSP70 on human microvascular endothelial cells (HMEC), we initially used gap-FRAP technique. Extracellular human HSP70 (rhHSP70), but not rhHSP27, blocks the gap-junction intercellular communication (GJIC) between HMEC, disrupts the structural integrity of HMEC junction plaques, and decreases connexin43 (Cx43) expression, which correlates with the phosphorylation of Cx43 serine residues. Further exploration of these effects identified a rapid transactivation of the Epidermal Growth Factor Receptor in a Toll-Like Receptor 4-dependent manner, preceding its in…
Zvaigžņotā Debess: 2016, Rudens (233)
2016
Latvijas Universitāte
Los laboratorios de la Junta para Ampliación de Estudios e Investigaciones Científicas (J.A.E.) y la Residencia de Estudiantes (1912-1939)
2007
-Jose.Luis.Barona@uv.es La política de jóvenes pensionados científicos en el extranjero desarrollada por la JAE tuvo un complemento importante en la puesta en marcha de una serie de pequeños laboratorios científicos y centros de investigación agrupados principalmente en el Instituto Nacional de Ciencias y la Residencia de Estudiantes. El presente artículo aporta una perspectiva general de la labor realizada por algunos de esos laboratorios, sus principales protagonistas y grupos de investigación, particularmente los relacionados con las investigaciones biomédicas. No se analiza la labor del Instituto Cajal o el Museo de Ciencias Naturales, que son objeto de otras contribuciones en este mism…
Data from: Plant – herbivorous beetle networks: molecular characterization of trophic ecology within a threatened steppic environment
2015
DNA barcoding facilitates many evolutionary and ecological studies, including the examination of the dietary diversity of herbivores. In this study, we present a survey of ecological associations between herbivorous beetles and host plants from seriously threatened European steppic grasslands. We determined host plants for the majority (65%) of steppic leaf beetles (55 species) and weevils (59) known from central Europe using two barcodes (trnL and rbcL) and two sequencing strategies (Sanger for mono/oligophagous species and Illumina for polyphagous taxa). To better understand the ecological associations between steppic beetles and their host plants, we tested the hypothesis that leaf beetl…
Combs and sexual selection in black grouse (Tetrao tetrix)
2000
We studied supra-orbital combs in lekking black grouse (Telrao tetrix) in relation to sexual selection at five leks in Finland 1991-1998 and four leks in Sweden 1992-1995. Comb size was estimated in two ways: by observing its natural size in the field at
Cuestiones religiosas en los Emblemata (Amberes, 1565) de Adriano Junio
2014
ABSTRACT: In this study I deal briefly with some issues related to the visual culture of the Baroque festival; and more specifically, with those related to the royal portraits that were on display during the festive activities. To this end I place special emphasis on developing the concepts of presence, body and virtuality –as applied to those works or visual objects– from an approach that offers a new theoretical framework, namely, that which involves «image studies» or «visual culture studies» (Bildwissenschaft, Bildanthropologie y visual studies). KEYWORDS: Baroque Festival, Royal Portraits, Presence, Body, Virtuality, Image Studies. RESUMEN: En el presente estudio abordaremos brevemente…
Can PBDEs affect the pathophysiologic complex of epithelium in lung diseases?
2020
Brominated flame-retardant (BFRs) exposure promotes multiple adverse health outcomes involved in oxidative stress, inflammation, and tissues damage. We investigated BFR effects, known as polybrominated diphenyl ethers (PBDEs) (47, 99 and 209) in an air-liquid-interface (ALI) airway tissue derived from A549 cell line, and compared with ALI culture of primary human bronchial epithelial cells (pHBEC). The cells, exposed to PBDEs (47, 99 and 209) (0.01-1 mu M) for 24 h, were studied for IL-8, Muc5AC and Muc5B (mRNAs and proteins) production, as well as NOX-4 (mRNA) expression. Furthermore, we evaluated tight junction (TJ) integrity by Trans-Epithelial Electrical Resistance (TEER) measurements, …
Analysis of soliton dynamics and noise induced effects on the superconductive lifetime in long Josephson junctions.
2013
The influence of various noise sources on the transient dynamics of long Josephson junctions (LJJ) is investigated in the presence of an oscillating bias current signal and a noise source with Gaussian or non-Gaussian (i.e. Cauchy-Lorentz or Lévy-Smirnov) probability distributions. These systems are computationally analyzed integrating the perturbed Sine-Gordon equation describing the phase evolution. We found evidence of noise induced effects on trends of the mean escape time (MET) from the superconductive metastable state, varying different system parameters, as the bias frequency, noise intensity and junction length. In particular, we find resonant activation (RA) and noise enhanced stab…
Transient dynamics in driven long Josephson junctions.
2013
The switching time from the superconductive metastable state of a long Josephson junction (LJJ)[1] is computationally analyzed in the framework of the perturbed sine-Gordon equation. The model includes an external bias current term and a stochastic noise source, i.e. a Lévy noise term. The effects of this noise on the mean escape time (MET) from the superconductive state are analyzed. The investigation is performed by considering a wide range of values of system parameters and different noise statistics: Gaussian, Cauchy-Lorentz and Lévy-Smirnov[2]. We found evidence of well known noise induced phenomena on the MET behavior, that is the noise enhanced stability (NES) and resonant activation…
Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex
2000
International audience; Defects in myosin VIIA are responsible for deafness in the human and mouse. The role of this unconventional myosin in the sensory hair cells of the inner ear is not yet understood. Here we show that the C-terminal FERM domain of myosin VIIA binds to a novel transmembrane protein, vezatin, which we identi®ed by a yeast two-hybrid screen. Vezatin is a ubiquitous protein of adherens cell±cell junctions, where it interacts with both myosin VIIA and the cadherin±catenins complex. Its recruitment to adherens junctions implicates the C-terminal region of a-catenin. Taken together, these data suggest that myosin VIIA, anchored by vezatin to the cadherin±catenins complex, cre…