Search results for " jun"
showing 10 items of 611 documents
Immune checkpoint inhibitors plus chemotherapy versus chemotherapy or immune checkpoint inhibitors for first- or second-line treatment of advanced ga…
2019
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To evaluate the efficacy and safety of immune checkpoint inhibitors, alone or in combination with chemotherapy, in people with advanced gastric and gastroesophageal junction adenocarcinoma in first and subsequent treatment lines.
I traffici illeciti nel Mediterraneo. Persone, stupefacenti, tabacco
2019
Attraverso la combinazione di ricerca criminologica e giuridico-normativa, e grazie anche alla collaborazione con esperti esterni (studiosi, magistrati, rappresentanti di istituzioni italiane e straniere), la ricerca da cui scaturisce il volume ha indagato le interazioni tra i diversi traffici illeciti e la criminalità organizzata nel bacino del Mediterraneo. In tale area, storicamente cruciale per la mobilità di persone e di beni, l’attenzione si è rivolta in particolare ai fenomeni del traffico e della tratta di persone, del traffico di stupefacenti e del contrabbando di sigarette. I contributi raccolti – unitamente al rapporto criminologico e ai cinque rapporti nazionali accessibili su w…
Assessing the biomass of shrubs typical of Mediterranean pre-forest communities
2012
One of the most outstanding issues of current environmental research is the need of reliable assessments of carbon stock (i.e. above-ground (a.g.) and below-ground biomass, deadwood, litter, and organic soil matter) within forest ecosystems. Although shrub vegetation plays an important role in accumulating carbon in many Mediterranean environments, there is still very little knowledge on the carbon they store. In this article, we analyze the a.g. carbon stock of several Mediterranean shrubby communities in Sicily (Italy), dominated by Pistacia lentiscus, Chamaerops humilis, Euphorbia dendroides and Spartium junceum. Plant samples for each species were selected, and morphometric attributes (…
Cell Systems Bioelectricity: How Different Intercellular Gap Junctions Could Regionalize a Multicellular Aggregate
2021
Simple Summary Electric potential patterns across tissues are instructive for development, regeneration, and tumorigenesis because they can influence transcription, migration, and differentiation through biochemical and biomechanical downstream processes. Determining the origins of the spatial domains of distinct potential, which in turn decide anatomical features such as limbs, eyes, brain, and heart, is critical to a mature understanding of how bioelectric signaling drives morphogenesis. We studied theoretically how connexin proteins with different voltage-gated gap junction conductances can maintain multicellular regions at distinct membrane potentials. We analyzed a minimal model that i…
Metastability and Relaxation in Quantum and Mesoscopic Systems
2013
The transient dynamics and the relaxation of three quantum and mesoscopic systems are investigated. In particular we analyze: (i) a long Josephson junction (LJJ) driven by a non-Gaussian Lévy noise current; (ii) a metastable quantum dissipative system driven by an external periodical driving; and (iii) the electron spin relaxation process in n-type GaAs crystals driven by a fluctuating electric field. Specifically, in the first system the LJJ phase evolution is described by the perturbed sine-Gordon equation. We find the noise enhanced stability and resonant activation phenomena, by investigating the mean escape time as a function of the bias current frequency, noise intensity and length of…
Staphylococcus aureus α-Toxin’s Close Contacts Ensure the Kill
2018
The membrane pore-forming α-toxin is an important virulence factor of Staphylococcus aureus. Target cells can remove pores from their surface, but recent work shows that α-toxin may undermine this self-defense by clinging to epithelial cell junctions. The findings could lead to the development of novel remedies against S. aureus infections.
Preparation of Ta-O-Based Tunnel Junctions to Obtain Artificial Synapses Based on Memristive Switching
2014
Magnetron sputtering and optical lithography are standard techniques to prepare magnetic tunnel junctions with lateral dimensions in the micrometer range. Here we present the materials and techniques to deposit the layer stacks, define the structures, and etch the devices. In the end, we obtain tunnel junction devices exhibiting memristive switching for potential use as artificial synapses.
Contrôle de nano-antennes optiques par une commande électrique : tuner plasmonique et transduction
2011
Optical nano-antennae are the new class of components to control light/matterinteraction at the nanoscale. These devices are operating in the visible to near infraredpart of the spectrum. The properties of these nano objects are controlled by theform, the size and the material.In the radio frequency domain, the tuner changes dynamically the operatingwavelength of the antenna. In this thesis work, we search to transfer this conceptto the nanoscale. The principle is to change the load impedance of the antenna, i.e.changing the optical index of the dielectric medium around the nano-object. Forthat we used anisotropic liquid cristal molecules. The value of the optical index iscontrolled by appl…
Microleakage comparison of glass-ionomer and white mineral trioxide aggregate used as a coronal barrier in nonvital bleaching
2011
Objectives: There is some evidence that the pH at the root surface is reduced by intracoronal placement of bleaching pastes, which is known to enhance osteoclastic activity. Therefore, it is recommended that a protective barrier be used over the canal filling to prevent leakage of bleaching agents. Glass-ionomer (GI) is commonly used as a coronal barrier before nonvital bleaching. Because mineral trioxide aggregate (MTA) creates high alkalinity after mixing with water, using MTA as a protective barrier over the canal filling may not only prevent leakage of bleaching agents and microorganisms, but may prevent cervical resorption. The aim of this study was to evaluate sealing ability of white…
Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis.
2004
The transcription factor c-Jun cooperates with oncogenic alleles of ras in malignant transformation. Constitutively active Ras causes, via activation of mitogen activated protein kinases, phosphorylation of c-Jun which is essential for subsequent target gene activation and tumorigenesis. Studying the mechanisms controlling c-Jun activity we found that its transcription activation function is actively repressed by a presumably multimeric repressor complex that includes histone deacetylase 3 as a critical subunit. Suppression of c-Jun is relieved by MAP kinase-mediated phosphorylation and/or titration of inhibitor components. The viral tumorigenic counterpart of c-Jun, v-Jun, escapes this inh…