Search results for " juvenil"
showing 10 items of 165 documents
Opportunistic infections in immunosuppressed patients with juvenile idiopathic arthritis: analysis by the Pharmachild Safety Adjudication Committee
2020
Background: To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC). Methods: The SAC (3 pediatric rheumatologists and 2 pediatric infectious disease specialists) elaborated and approved by consensus a provisional list of OI for use in JIA. Through a 5 step-procedure, all the severe and serious infections, classified as per MedDRA dictionary and retrieved in the Pharmachild registry, were evaluated by the SAC by answering six questions and adjudicated with the agreement of 3/5 specialists. A final evidence-based list of OI resulted by matching …
Two-year Efficacy and Safety of Etanercept in Pediatric Patients with Extended Oligoarthritis, Enthesitis-related Arthritis, or Psoriatic Arthritis.
2015
Objective.The main objective was to determine the 2-year clinical benefit and safety of etanercept (ETN) in children with the juvenile idiopathic arthritis (JIA) categories of extended oligoarthritis (eoJIA), enthesitis-related arthritis (ERA), or psoriatic arthritis (PsA).Methods.CLIPPER was a 96-week, phase IIIb, open-label, multicenter study. Patients with eoJIA, ERA, or PsA received ETN 0.8 mg/kg once weekly (50 mg max) for up to 96 weeks. The proportions of patients reaching the JIA American College of Rheumatology (ACR) 30/50/70/90/100 and inactive disease responses at Week 96 were calculated. Adverse events (AE) were collected throughout the study (intention-to-treat sample).Results.…
Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study
2019
Made available in DSpace on 2019-10-05T16:54:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-01 IRCCS Istituto Giannina Gaslini Background To our knowledge, the characteristics and burden of childhood arthritis have never been studied on a worldwide basis. We aimed to investigate, with a cross-sectional study, the prevalence of disease categories, treatment methods, and disease status in patients from across different geographical areas and from countries with diverse wealth status. Methods In this multinational, cross-sectional, observational cohort study, we asked international paediatric rheumatologists from specialised centres to enrol children with a diagnosis of juvenile …
West syndrome followed by juvenile myoclonic epilepsy: a coincidental occurrence?
2013
Background: West syndrome is an age-dependent epilepsy with onset peak in the first year of life whose aetiology may be symptomatic or cryptogenic. Long-term cognitive and neurological prognosis is usually poor and seizure outcome is also variable. Over the past two decades a few patients with favourable cognitive outcome and with total recovery from seizures were identified among the cryptogenic group suggesting an idiopathic aetiology. Recent research has described two children with idiopathic WS who later developed a childhood absence epilepsy. Case presentation: We reviewed the medical records of patients with West syndrome admitted to the our Child Neuropsychiatry Unit in the last 15 y…
Evaluation of Fitness and the Balance Levels of Children with a Diagnosis of Juvenile Idiopathic Arthritis: A Pilot Study
2017
Background: Juvenile idiopathic arthritis is a main cause of physical disability and has high economic costs for society. The purpose of this study was to assess the fitness levels and the postural and balance deficits with a specific test battery. Methods: Fifty-six subjects were enrolled in this study. Thirty-nine healthy subjects were included in the control group and seventeen in the juvenile idiopathic arthritis group. All subjects were evaluated using a posturography system. The fitness level was evaluated with a battery of tests (Abalakov test, sit-up test, hand grip test, backsaver sit and reach, the toe touch test). An unpaired t-test was used to determine differences. Pearson’s co…
Perception of Dating Violence in Teenage Couples: A Cross Validation Study in Spain and Colombia
2020
Background: dating violence, or violence in teenage couples, is a socially interesting topic, due to its prevalence and its possible use in predicting violence in adult couples. The perception of violence, or the detection of abusive behaviors by teenagers and young people (which can be considered as equivalent concepts), is essential to prevent violence itself. Therefore, the main objective of this research is to determine which behaviors are identified as abusive by teenagers and young people, and the severity that they attribute to them&mdash
La justicia juvenil en España : una responsabilidad colectiva. Propuestas desde el Trabajo Social
2016
El presente trabajo realiza una revisión y análisis de los paradigmas y tratamiento recibido por el menor de edad que comete hechos delictivos a partir de los modelos teóricos de justicia basados en la responsabilidad y en el supremo interés del menor, centrando el análisis en España. Del mismo modo refiere la percepción social que tienen los delincuentes juveniles y cómo afecta a sus relaciones con el delito. Se informa de nuevos perfiles de menores delincuentes, tipos penales y las etiquetas que sufren. Finalmente se describen una serie de propuestas de corte comunitario y otras que afectan a los principales implicados por la justicia juvenil: los menores, las víctimas, las familias y la …
Primary Microcephaly with Novel Variant of MCPH1 Gene in Twins: Both Manifesting in Childhood at the Same Time with Hashimoto's Thyroiditis
2020
AbstractThis study is a clinical report on twin females affected by primary microcephaly who displayed at molecular analysis of heterozygous novel MCPH1 variant. The twins at the age of 10 years developed, in coincidental time, a diagnosis of autoimmune juvenile thyroiditis. The main clinical features presented by the twins consisted of primary microcephaly with occipitofrontal circumference measuring −2 or −3 standard deviation, facial dysmorphism, typical nonsyndromic microcephaly, and mild intellectual disability. Molecular analysis of the major genes involved in primary microcephaly was performed and the following result was found in the twins: MCPH1; chr8.6357416; c.2180 C > T (rs 1…
Hoy es el futuro : de la activación universitaria a las respuestas colectivas frente a la precariedad juvenil.
2014
La precarización de la juventud universitaria discurre en paralelo a la intensificación de los mensajes sobre la activación. Estos mensajes, apoyados en la noción de la empleabilidad, responsabilizan a los jóvenes de las dificultades para encontrar empleos mínimamente dignos. Frente a esta doble agresión (la precarización y su legitimación), una parte de la juventud ha articulado respuestas colectivas y ha desplegado estrategias de resignificación y visibilización del conflicto social. En el presente texto examinamos críticamente el proceso de extensión de la doctrina neoliberal de la activación en relación a la universidad y analizamos las acciones de Juventud Sin Futuro, una iniciativa co…
Heather tiene 25 años. Madres y familias diversas en la literatura para primeros lectores (1990-2015)
2019
[EN] In 1989 was published the first edition of Heather has two mommies , that is considered the first children’s book of great diffusion about lesbian mothers. In Spain it was translated in 2003 under the title Paula tiene dos mamás. Since then, we have seen various legislative and social changes that have led to the generalization of this type of literature, although limited in most cases to some family and educational environments. On the other hand, the authors’ initial intention (to provide the sons and daughters of lesbian women with positive references of their own family models) has been complemented with other publications addressed to all the children from an inclusive and normali…