Search results for " kappa"
showing 10 items of 61 documents
Traditional Chinese herbal medicine at the forefront battle against COVID-19: Clinical experience and scientific basis.
2020
Abstract Background Throughout the 5000-year history of China, more than 300 epidemics were recorded. Traditional Chinese herbal medicine (TCM) has been used effectively to combat each of these epidemics’ infections, and saved many lives. To date, there are hundreds of herbal TCM formulae developed for the purpose of prevention and treatment during epidemic infections. When COVID-19 ravaged the Wuhan district in China in early January 2020, without a deep understanding about the nature of COVID-19, patients admitted to the TCM Hospital in Wuhan were immediately treated with TCM and reported later with >90% efficacy. Approach We conducted conduct a systematic survey of various TCM herbal pre…
A case of Waldenstroem's disease with a monoclonal IgM antiphospholipid antibody
2002
The antiphospholipid syndrome (APS) was described in 1983 as a clinical entity characterized by venous and arterial thrombosis, thrombocytopenia, and recurrent fetal loss. The serological markers of APS are antiphospholipid antibodies (APLA) directed mainly against anionic phospholipids, usually cardiolipin but also phosphatidylserine. Some APLA exhibit lupus anticoagulant activity. Monoclonal gammopathy sometimes occurs with the presence of autoantibodies. In this paper, we describe a patient with the diagnosis of immunocytoma with an IgM, kappa paraprotein with apparent specificity against anionic phospholipids, and lupus anticoagulant activity, but no clinical signs of APS. We describe i…
High sensitivity of free lambda and free kappa light chains for detection of intrathecal immunoglobulin synthesis in cerebrospinal fluid.
2008
Background – So far, an inflammation of the central nervous system (CNS) is diagnosed by immunoglobulin measurement in cerebrospinal fluid (CSF) and serum as well as by determination of the oligoclonal bands. With the free kappa and lambda light chains, new markers to diagnose intrathecal synthesis are available. Methods – In addition to routine diagnostic tests and the assessment of standard parameters, free immunoglobulin light chains were measured in the CSF of patients with neurological disorders. Results – A significant agreement was found between an increase in free kappa light chain CSF serum quotients and results of the currently widely applied method of oligoclonal band measurem…
An evaluation of exposure metrics in an epidemiologic study on radio and television broadcast transmitters and the risk of childhood leukemia.
2009
Electric field strength values calculated by wave propagation modeling were applied as an exposure metric in a case–control study conducted in Germany to investigate a possible association between radio frequency electromagnetic fields (RF-EMF) emitted from television and radio broadcast transmitters and the risk of childhood leukemia. To validate this approach it was examined at 850 measurement sites whether calculated RF-EMF are an improvement to an exposure proxy based on distance from the place of residence to a transmitter. Further, the agreement between measured and calculated RF-EMF was explored. For dichotomization at the 90% quantiles of the exposure distributions it was found that…
Age-dependent regulation of antioxidant genes by p38α MAPK in the liver
2018
p38α is a redox sensitive MAPK activated by pro-inflammatory cytokines and environmental, genotoxic and endoplasmic reticulum stresses. The aim of this work was to assess whether p38α controls the antioxidant defense in the liver, and if so, to elucidate the mechanism(s) involved and the age-related changes. For this purpose, we used liver-specific p38α-deficient mice at two different ages: young-mice (4 months-old) and old-mice (24 months-old). The liver of young p38α knock-out mice exhibited a decrease in GSH levels and an increase in GSSG/GSH ratio and malondialdehyde levels. However, old mice deficient in p38α had higher hepatic GSH levels and lower GSSG/GSH ratio than young p38α knock-…
The Relationship Between Tooth Size Discrepancy and Archform Classification in Orthodontic Patients
2015
Background: To determine the relationship between clinically significant tooth size discrepancies (TSD) and archform classification in orthodontic patients. Material and Methods: Two hundred and forty consecutive sets of pre-treatment orthodontic study models were scanned and landmarked. All models had permanent teeth erupted from first molar to first molar in both arches. Sixty sets of images were classified into two groups of 30 according to the presence (group 1) or absence (group 2) of a clinically significant overall or anterior TSD (>2 SD from Bolton’s original means). Mean upper and lower archforms were created for each group using a fourth degree polynomial curve. Upper and lower ar…
Comparison of MeSH terms and KeyWords Plus terms for more accurate classification in medical research fields. A case study in cannabis research
2021
Abstract KeyWords Plus and Medical Subject Headings (MeSH) are widely used in bibliometric studies for topic mapping. The objective of this study is to compare the two description systems in documents about cannabis research to find the concordance between systems and establish whether there is neutrality in topic mapping. A total of 25,593 articles from 1970 to 2019 were drawn from Web of Science's Core Collection and Medline and analyzed. The tidytext library, Zipf's law, topic modeling tools, the contingency coefficient, Cramer's V, and Cohen's kappa were used. The results included 10,107 MeSH terms and 28,870 KeyWords Plus terms. The Zipf distribution of the terms was different for each…
Validation of Semantic Analyses of Unstructured Medical Data for Research Purposes
2019
BACKGROUND: In secondary data there are often unstructured free texts. The aim of this study was to validate a text mining system to extract unstructured medical data for research purposes. METHODS: From a radiological department, 1,000 out of 7,102 CT findings were randomly selected. These were manually divided into defined groups by 2 physicians. For automated tagging and reporting, the text analysis software Averbis Extraction Platform (AEP) was used. Special features of the system are a morphological analysis for the decomposition of compound words as well as the recognition of noun phrases, abbreviations and negated statements. Based on the extracted standardized keywords, findings rep…
Development and validation of new methods for the study of oxidative stress by Imaging Flow Cytometry
2017
El estrés oxidativo se origina debido a un desequilibrio entre la producción de especies reactivas de oxígeno (ROS) y los mecanismos celulares antioxidantes. Este desequilibrio en el estado normal redox puede causar efectos tóxicos a través de la producción de radicales libres y peróxidos, que dañan a componentes esenciales de la célula, como proteínas, lípidos y ADN. Actualmente se cree que el estrés oxidativo está relacionado con los mecanismos en un gran número de enfermedades degenerativas y cáncer, y también se le atribuye un papel importante en el proceso de envejecimiento. En algunos casos, la producción de especies reactivas de oxígeno (ROS) no es un fenómeno indeseable sino que for…
Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor {kappa}B.
2009
Cells of the monocyte-macrophage lineage play a central role in the orchestration and resolution of inflammation. Plasticity is a hallmark of mononuclear phagocytes, and in response to environmental signals these cells undergo different forms of polarized activation, the extremes of which are called classic or M1 and alternative or M2. NF-kappaB is a key regulator of inflammation and resolution, and its activation is subject to multiple levels of regulation, including inhibitory, which finely tune macrophage functions. Here we identify the p50 subunit of NF-kappaB as a key regulator of M2-driven inflammatory reactions in vitro and in vivo. p50 NF-kappaB inhibits NF-kappaB-driven, M1-polariz…