Search results for " key"

Multiclass HCV resistance to direct-acting antiviral failure in real-life patients advocates for tailored second-line therapies

2017

Background & Aims: Despite the excellent efficacy of direct-acting antivirals (DAA) reported in clinical trials, virological failures can occur, often associated with the development of resistance-associated substitutions (RASs). This study aimed to characterize the presence of clinically relevant RASs to all classes in real-life DAA failures. Methods: Of the 200 virological failures that were analyzed in 197 DAA-treated patients, 89 with pegylated-interferon+ribavirin (PegIFN+RBV) and 111 without (HCV-1a/1b/1g/2/3/4=58/83/1/6/24/25; 56.8% treatment experienced; 65.5% cirrhotic) were observed. Sanger sequencing of NS3/NS5A/NS5B was performed by home-made protocols, at failure (N= 200) and w…

Female control of paternity in the sexually cannibalistic spider Argiope keyserlingi.

2000

Sexual conflict theory predicts an antagonistic coevolution, with each sex evolving adaptations and counter-adaptations to overcome a temporary dominance of the other sex over the control of paternity. Polyandry allows sexual selection to operate after mating has commenced, with male and female interests competing for control of fertilization. There are numerous examples of male control of paternity, but few studies have unambiguously revealed female control. Attributing variance in paternity to females is often difficult since male and female influences cannot be separated unambiguously. However, we show that polyandrous female orb-web spiders Argiope keserlingi (Arancidae) control the pat…

The genus Tuponia Reuter, 1875 in Romania, with two new synonymies (Heteroptera: Miridae)

2021

Based on recently collected material and on type specimens deposited in the collections of Muzeul de Istorie Naturală “Grigore Antipa”, Bucharest, Romania, and of the Zoologische Museum, Universität Hamburg, Germany, the following new synonymies are proposed: Tuponia (Chlorotuponia) prasina (Fieber, 1864) = Tuponia (Chlorotuponia) linnavuorii Wagner, 1961, syn. n.; Tuponia (Tuponia) montandoni Reuter, 1899 = Tuponia (Tuponia) macedonica Wagner, 1957, syn. n. Lectotype and paralectotype are designated for Tuponia (Tuponia) montandoni Reuter, 1899. Tuponia (Chlorotuponia) hippophaes (Fieber, 1861), Tuponia (Tuponia) arcufera Reuter, 1879 and Tuponia (Tuponia) elegans (Jakovlev, 1867) are reco…

Towards reliable identification of male Dicerura: descriptions of three new and seven poorly known species in the Palearctic region (Diptera: Cecidom…

2018

The taxonomy of Dicerura Kieffer, 1898, a genus of Porricondylinae now comprising 32 species in the Holarctic region, is revised. Three new species are described based on morphological characters of male adults: D. jakovlevi Jaschhof & Spungis sp. nov. (from Finland), D. penttineni Jaschhof & Spungis sp. nov. (Finland), and D. yezoensis Jaschhof & Spungis sp. nov. (Japan). Dicerura padi Mamaev, 1975 syn. nov. is revealed to be a junior synonym of D. furculata Mamaev, 1968. Seven species, whose original descriptions are from a present-day perspective inadequate for the purpose of identification, are redescribed: D. barbata Mamaev, 1966; D. formosa Mamaev, 1998; D. foliicola Mamae…

Efficacy and safety of yttrium 90 ibritumomab tiuxetan in patients with relapsed or refractory diffuse large B-cell lymphoma not appropriate for auto…

2007

A prospective, multicenter, nonrandomized phase 2 trial was conducted to evaluate the efficacy and safety of a single dose of yttrium-90 (90Y) ibritumomab tiuxetan in elderly patients in first relapsed or primary refractory diffuse large B-cell lymphoma (DLBCL) ineligible for stem-cell transplantation. Patients had been previously treated with chemotherapy (group A, n = 76) or chemotherapy plus rituximab (group B, n = 28). Patients in group A were further divided into patients in whom induction therapy had failed (stratum AI, n = 33) and patients who had relapsed after achieving complete response (CR; stratum AII, n = 43). The overall response rate (ORR) was 52% and 53% in strata AI and AII…

A Brief History of Political Economy: Tales of Marx, Keynes and Hayek

2018

Polarization insensitive wavelength conversion of 40 Gb/s DPSK signals in a silicon germanium waveguide

2015

We demonstrate polarization insensitive FWM-based wavelength conversion of 40Gb/s DPSK signals in a SiGe waveguide, with 0.42-dB polarization-dependent loss. A 1.5-dB Dower nenaltv was measured at a BER of 10−9.

La location de l'usage : une interprétation écoresponsable du service ? : cas des biens en partage

2013

Offers of sharing services are springing up in cities: Vélib’, Autolib’, carsharing.... Using up involves sharing the service with multiple users and agreeing to separate oneself from all materialism in favor of functionality. This is also an argument towards a more responsible consumption. Hiring or buying, what does the consumer think about it? The value lies in the benefits of use rather than in its possession. It is also a new meaningful experience accepted, tinkered, refused or reinterpreted by the consumers. According to the Grounded Theory principles, a data collection based on life stories, it provides us new information on the attractiveness of this offer of service; and according …

Morphometric and hydraulic geometry assessment of a gully in SW Spain

2016

Abstract Gully erosion represents one of the most significant types of land degradation in the Mediterranean areas, giving place to important on- and off-site effects. In this paper, a second-order gully located in SW Spain is analyzed. Along the gully, 28 cross-sections were established and measured with a Leica TCRM1102 laser total station, approximately every 6 months from 2001 to 2007. The sections were located at variable distance, placing them in areas where active erosion was evident. In total, 13 field measurements were carried out, and the geometric characteristics of 28 cross-sections were obtained. Morphometric analyses were carried out in both the main gully and a tributary reac…

Mediterranean Paths The Construction of Vaults in Southern Italy, Sicily and Sardinia (15th–16th Centuries)

2019

Nel meridione della penisola italiana e nelle grandi isole, la costruzione delle volte nel XV e nel XVI secolo è stata caratterizzata da una peculiare coesistenza di continuità e innovazione. Le volte costruite in questo ampio territorio nei secoli in questione si possono suddividere in due grandi categorie di artefatti, che rispondono a criteri costruttivi, formali e geometrici differenti: le crociere con costoloni e i padiglioni di varia geometria. In questo ricco e variegato panorama, il saggio si sofferma ad analizzare alcune soluzioni di dettaglio e singoli elementi di strutture più articolate, che restituiscono tuttavia appieno il complesso intreccio di modelli e abilità tecniche, di …