Search results for " laboratorio"
showing 10 items of 107 documents
Focused Ultrasound Effects on Osteosarcoma Cell Lines
2019
MRI guided Focused Ultrasound (MRgFUS) has shown to be effective therapeutic modality for non-invasive clinical interventions in ablating of uterine fibroids, in bone metastasis palliative treatments, and in breast, liver, and prostate cancer ablation. MRgFUS combines high intensity focused ultrasound (HIFU) with MRI images for treatment planning and real time thermometry monitoring, thus enabling non-invasive ablation of tumor tissue. Although in the literature there are several studies on the Ultrasound (US) effects on cell in culture, there is no systematic evidence of the biological effect of Magnetic Resonance guided Focused Ultrasound Surgery (MRgFUS) treatment on osteosarcoma cells, …
Cancer cell targeting by CAR-T cells: A matter of stemness
2022
Chimeric antigen receptor (CAR)-T cell therapy represents one of the most innovative immunotherapy approaches. The encouraging results achieved by CAR-T cell therapy in hematological disorders paved the way for the employment of CAR engineered T cells in different types of solid tumors. This adoptive cell therapy represents a selective and efficacious approach to eradicate tumors through the recognition of tumor-associated antigens (TAAs). Binding of engineered CAR-T cells to TAAs provokes the release of several cytokines, granzyme, and perforin that ultimately lead to cancer cells elimination and patient’s immune system boosting. Within the tumor mass a subpopulation of cancer cells, known…
Calidad, Validación de métodos, Control de calidad, Incertidumbre, Acreditación de laboratorios
2010
Describir e ilustrar con un ejemplo el procedimiento a seguir para armonizar tres procesos internos de calidad, relacionados con un método de análisis, en el laboratorio de ensayo, LE: Validación de la exactitud, Control de calidad y Expresión de la incertidumbre. Además, la Guía se ha diseñado para que el usuario (estudiante o profesional) alcance competencias y cualificación suficiente para ejecutar correctamente un documento del sistema de calidad del LE y poder cumplimentar un registro de validación de manera conforme. Finalmente, la Guía (en sí misma, junto al resto de documentos que la componen) pretende servir de orientación didáctica al usuario sobre algunos aspectos clave de un sis…
Le camere riverberanti presso il laboratorio di acustica dell’Università di Palermo
2010
Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids
2021
AbstractThe prognosis of locally advanced colorectal cancer (CRC) is currently unsatisfactory. This is mainly due to drug resistance, recurrence, and subsequent metastatic dissemination, which are sustained by the cancer stem cell (CSC) population. The main driver of the CSC gene expression program is Wnt signaling, and previous reports indicate that Wnt3a can activate p38 MAPK. Besides, p38 was shown to feed into the canonical Wnt/β-catenin pathway. Here we show that patient-derived locally advanced CRC stem cells (CRC-SCs) are characterized by increased expression of p38α and are “addicted” to its kinase activity. Of note, we found that stage III CRC patients with high p38α levels display…
La casa ipertestuale. Libertà e complessità nell'abitare
2008
L'articolo fa riferimento, in generale, all’esperienza del workshop "Futura, come abiteremo domani" che ha avuto luogo nei laboratori della Facoltà di Architettura di Palermo nel marzo del 2005. Iniziativa nata da una sollecitazione di Lucio Dalla ed in collaborazione con Expa, galleria di Architettura. Al workshop hanno partecipato studenti della facoltà provenienti dai corsi di laurea in Architettura 4/s e Disegno Industriale, e si è articolato in sei laboratori diretti dai professori Teresa La Rocca (coordinatore), Emanuele Palazzotto, Marcello Panzarella, Michele Sbacchi, Andrea Sciascia, Viviana Trapani. In particolare, il tema di progetto affrontato all’interno del Laboratorio del Pro…
Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer
2023
Abstract Background Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated with epithelial-mesenchymal transition and stromal infiltration (Guinney et al., Nat Med 21:1350–6, 2015; Linnekamp et al., Cell Death Differ 25:616–33, 2018), whereas clinically it is characterized by lower responses to adjuvant therapy, higher incidence of metastatic spreading and hence dismal prognosis (Buikhuisen et al., Oncogenesis 9:66, 2020). Methods To understand the biology of the mesenchymal subtype and unveil specific vulnerabilities, a large CRISPR-Cas9 drop-out screen was performed on 14 subtyped CRC cell lines to un…
Il laboratorio di chimica
2001
Progetti in Fiera. Progetti urbani degli studenti del Laboratorio di Progettazione Architettonica 2°
2012
La recensione riguarda il libro di Antonio Marino (con Francesco Messina) intitolato "Progetti in Fiera", Liriti Editore, Reggio Calabria (2010). Si tratta di una pubblicazione degli esiti dei Laboratori di Progettazione Architettonica 2° della Facoltà di Reggio Calabria, del Prof. Nino Marino, che ha scelto, per tre anni consecutivi, a partire dall'a.a. 2005-2006, la cittadella Fieristica messinese quale campo di applicazione privilegiato di sperimentazione didattica.
Laboratorio I di Progettazione Architettonica
2014
Il breve saggio definisce le linee guida della didattica della progettazione architettonica del I anno specificandone gli obbiettivi, i contenuti e le finalità.