Search results for " latency"
showing 10 items of 65 documents
Brain Cortical Complexity and Subcortical Morphometrics in Lifelong Premature Ejaculation
2020
Premature ejaculation (PE) is the most common male sexual dysfunction. The brain disturbances that cause this disorder remain poorly understood. This study aimed to investigate how the morphology of cortical and subcortical brain structures differed in PE, how these morphologic differences were associated with severity measures of PE, such as intravaginal ejaculatory latency time (IELT), and how these cortical and subcortical structures were causally connected through mediation analysis. Anatomical MRI scans were acquired from 39 male participants, 23 with PE (28.78 ± 4.32 years), and 16 without PE (27.88 ± 3.65 years). We used a subcortical analysis package within FSL to perform subcortica…
Immune Evasion Proteins Enhance Cytomegalovirus Latency in the Lungs
2009
ABSTRACT CD8 T cells control cytomegalovirus (CMV) infection in bone marrow transplantation recipients and persist in latently infected lungs as effector memory cells for continuous sensing of reactivated viral gene expression. Here we have addressed the question of whether viral immunoevasins, glycoproteins that specifically interfere with antigen presentation to CD8 T cells, have an impact on viral latency in the murine model. The data show that deletion of immunoevasin genes in murine CMV accelerates the clearance of productive infection during hematopoietic reconstitution and leads to a reduced latent viral genome load, reduced latency-associated viral transcription, and a lower inciden…
CD8 T Cells Control Cytomegalovirus Latency by Epitope-Specific Sensing of Transcriptional Reactivation
2006
ABSTRACT During murine cytomegalovirus (mCMV) latency in the lungs, most of the viral genomes are transcriptionally silent at the major immediate-early locus, but rare and stochastic episodes of desilencing lead to the expression of IE1 transcripts. This low-frequency but perpetual expression is accompanied by an activation of lung-resident effector-memory CD8 T cells specific for the antigenic peptide 168-YPHFMPTNL-176, which is derivedfrom the IE1 protein. These molecular and immunological findings were combined in the “silencing/desilencing and immune sensing hypothesis” of cytomegalovirus latency and reactivation. This hypothesis proposes that IE1 gene expression proceeds to cell surfac…
Ontology and protocol secure for SCADA: Int. J. of Metadata, Semantics and Ontologies, 2014 Vol.9, No.2, pp.114 - 127
2014
International audience; In this work, we present a semantic cyber security system and we study its semantic intelligent systems vulnerabilities, focusing on the semantic attacks. For resolving semantic problems we propose a security global solution for the new generation of SCADA systems. The proposed solution aims at protecting critical semantic SCADA processes from the effects of major failures and semantic vulnerabilities in the modern IT-SCADA network. We used a security block in the global network access point, security protocols deployed in different network (OSI) levels and security ontologies deployed in security devices. We used our mixed coordinates (ECC) cryptography solution, th…
IP-Based Mobility Management and Handover Latency Measurement in heterogeneous environments
2017
International audience; One serious concern in the ubiquitous networks is the seamless vertical handover management between different wireless technologies. To meet this challenge, many standardization organizations proposed different protocols at different layers of the protocol stack. The Internet Engineering Task Force (IETF) has different groups working on mobility at IP level in order to enhance mobile IPv4 and mobile IPv6 with different variants: HMIPv6 (Hierarchical Mobile IPv6), FMIPv6 (Fast Mobile IPv6) and PMIPv6 (Proxy Mobile IPv6) for seamless handover. Moreover, the IEEE 802.21 standard provides another framework for seamless handover. The 3GPP standard provides the Access Netw…
PV-Alert: Fog Computing based Architecture for Safeguarding Vulnerable Road Users
2018
High volumes of pedestrians, cyclists and other vulnerable road users (VRUs) have much higher casualty rates per mile; not surprising given their lack of protection from an accident. In order to alleviate the problem, sensing capabilities of smartphones can be used to detect, warn and safeguard these road users. In this research we propose an infrastructure-less fog-based architecture named PV-Alert (Pedestrian-Vehicle Alert) where fog nodes process delay sensitive data obtained from smartphones for alerting pedestrians and drivers before sending the data to the cloud for further analysis. Fog computing is considered in developing the architecture since it is an emerging paradigm that has p…
Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1) RUNX1-RUNX1T1 Identifies Patients at High Risk o…
2019
Background: Acute myeloid leukemia (AML) with t(8;21)(q22;q22.1) resulting in the RUNX1-RUNX1T1 gene fusion is considered favorable in the 2017 genetic risk stratification by the European LeukemiaNet (ELN). After intensive chemotherapy most patients (pts) achieve complete remission (CR), but relapse occurs in about 50% and is associated with poor prognosis. In this AML subgroup monitoring of measurable residual disease (MRD) has been shown to identify pts at higher risk of relapse. Aims: To assess the prognostic impact of MRD monitoring in bone marrow (BM) and peripheral blood (PB) in a large cohort of 155 clinically well-annotated t(8;21)-AML pts enrolled in one of six AMLSG treatment tria…
Acupressure therapy for insomnia in adolescents: a polysomnographic study
2013
Marco Carotenuto,1 Beatrice Gallai,2 Lucia Parisi,3 Michele Roccella,3 Maria Esposito11Sleep Clinic for Developmental Age, Clinic of Child and Adolescent Neuropsychiatry, Second University of Naples, Naples, 2Unit of Child and Adolescent Neuropsychiatry, University of Perugia, Perugia, 3Child Neuropsychiatry, Department of Psychology, University of Palermo, Palermo, ItalyBackground: The purpose of this study was to assess the efficacy of acupressure therapy in a sample of adolescents with insomnia using a standard polysomnographic evaluation.Methods: For this study, 25 adolescents affected by psychophysiological insomnia (mean age 15.04 ± 1.18 years, 12 boys) were enrolled. A dev…
Title effect of multicomponent cognitive behavioral therapy in a sample of chronic insomniacs in hypnotic treatment
2013
Introduction The objective of this study is to analyze the improvements in sleep and quality of life, as well as to evaluate the decrease or cessation of drug treatment in a sample of insomniacs in hypnotic drug treatment after CBT-I application. Materials and methods This is a pre-post quasi-experimental design, with a monitoring performed 6 months later in which information of an Experimental Group (EG = 17) is given and evaluated during three times, and also a Control Group (CG = 44), with measures only at the pre- post. According to Perlis Protocol and after an Insomnia Interview by Morin, all patients qualified as candidates for CBTI. Patients were given a daily sleep log and the Spa…
Prioritization of Alternatives with AHP Plus Response Latency and Web Surveys
2013
Purpose: Overcome some drawbacks of the widely applied Analytical Hierarchy Process (AHP) related to the use of a rating scale for respondent’s judgments and propose a new method to prioritize alternatives based on web surveys. Methodology/Approach: We use the response latency, i.e. the time taken to make a decision, to replace the rating scale in the pairwise comparisons which is a fundamental part of the AHP procedure. A method combining the AHP with a mathematical model for the response latency is proposed in the paper. Findings: Eliminating the rating scale and leaving only the “take the best” task alleviates the respondent and makes the survey much faster and intuitive. Moreover the re…