Search results for " lead"
showing 10 items of 499 documents
Fragment- and negative image-based screening of phosphodiesterase 10A inhibitors.
2019
A novel virtual screening methodology called fragment- and negative image-based (F-NiB) screening is introduced and tested experimentally using phosphodiesterase 10A (PDE10A) as a case study. Potent PDE10A-specific small-molecule inhibitors are actively sought after for their antipsychotic and neuroprotective effects. The F-NiB combines features from both fragment-based drug discovery and negative image-based (NIB) screening methodologies to facilitate rational drug discovery. The selected structural parts of protein-bound ligand(s) are seamlessly combined with the negative image of the target's ligand-binding cavity. This cavity- and fragment-based hybrid model, namely its shape and electr…
La vida cotidiana de los vecinos de Manila a través de sus testamentos e inventarios de bienes
2019
With the general objective indicated in its title, this work tries to highlight relevant aspects in the continuity of the Spanish domain in the Philippines, dependent on the maintenance of the Spanish capital. The inevitable selection of topics has lead the preferences of this work towards the residents collaboration to defend the city, the conversion of many of them into traders of exotic products and singular slaves owners, and their collaboration to an incredible miscegenation due to the ethnic variety. On the other hand, to follow the footsteps of the first generation of residents in Manila, at the end of the 16th century and during the 17th century, this work gives us some information …
Constructing the Audit Risk Assessment by the Audit Team Leader When Planning: Using Fuzzy Theory
2021
The aim of this study is to construct the assessment of the expected audit risk by the audit team leader (ATL) during the planification phase of the audit. The ATL plays an important role within the audit, and even more so regarding small and medium-sized (SME) audit firms. The audit risk assessment is critical as relying more (less) on internal controls implemented by the client leads to performing less (more) substantive audit procedures. This is determined by the ATL based on their professional judgement and previous experience. The use of fuzzy theory has powerful potential into the audit arena, as the audit risk assessment (outcome) is critically related to the auditors’ judgement and …
Valdas Adamkus un Vaira Vīķe –Freiberga: rietumu politiskā līderība postkomunistiskā Lietuvā un Latvijā
2016
Vaira Vīķe-Freiberga un Valdas Adamkus ir divi izcili politiskas līderības paraugi Latvijā un Lietuvā. Viņu politiskie uzskati nobrieda trimdā Rietumos, bet prezidentiem bija jācenšas tos uzskatus pielietot postkomunistiskā Latvijas un Lietuvas realitātē. Adamkus mēģināja transformēt politisko kultūru un partiju sistēmu; bet kad viņam tas neizdevās viņš koncentrējās uz ārpolitiskiem mērķiem un mēģināja atbalstīt reformas citas postkomunistiskajās valstīs, arī popularizēt pilsoniskās sabiedrības idejas savā valstī. Vīķe-Freiberga apņēmās pacelt Latvijas pašpārliecību mājās un starptautisko organizāciju acīs. Šis maģistra darbs ir mēģinājums salīdzināt prezidentu politiskās stratēģijas Rietum…
State and Politics in Religious Peacebuilding in Kenya, Zanzibar and Rwanda
2016
In this chapter, Steen-Johnsen argues that the question how do the political strategies of the state to regulate to the civil sphere and the enactment of these strategies influence the scope of opportunity for religious actors to build peace is relevant in contexts beyond Ethiopia. Steen-Johnsen presents three different African contexts: Kenya, Zanzibar and Rwanda, where political strategies to regulate the civil and religious spheres exist in different forms. Steen-Johnsen outlines how state authorities in these contexts, through different means, have launched political strategies to curb, or to some extent control, conflicts with religious dimensions. This, she argues, prompts the questio…
Theory on State and Politics in Religious Peacebuilding
2016
In this chapter, Steen-Johnsen offers an overview over theoretical perspectives which allow us to consider how the political strategies of a state to regulate civil society influence the opportunities of religious peacebuilders. Drawing upon theories of state–civil interactions, she suggests that religious actors engaged in peacebuilding can be considered as being affected by political strategies aiming at regulating the civil sphere. Steen-Johnsen argues that the state and civil spheres are interlinked and mutually influential but warns against viewing actors in the civil sphere as dictated by the political strategies of a state authority. Religious actors should rather should rather be co…
Perception of Political Leadership in Local Governments in Latvia
2018
Theme of the paper is political leadership in local governments in Latvia. The work uses secondary data analysis and case studies. The aim of the study is to find out what kind of role does the chairperson of the municipality have as a political leader and what kinds of factors are influencing him/her. The results revealed that formally the chairperson of the municipality has no decisive influence on the municipality and that both types of factors (internal and external) interact with each other limiting the political leader’s (chairperson’s of a municipality) freedom of action.
Is leaders’ mood contagious to team members? The mediator role of team mood and team potency in the relationship between leaders’ mood and team perfo…
2015
Comunicação apresentada no 17º Congresso da European Association of Work and Organizational Psychology, 20-23 de maio de 2015, Oslo, Noruega
ETHICAL LEADERSHIP: STUDENT PERCEPTIONS OF EXERCISING ETHICAL INFLUENCE IN ORGANIZATION
2014
Today’s rapidly changing economic and social environment requires reconsideration of leadership issues, a special attention paying to ethical issues that are an integral part of socially responsible business. There are numerous studies on the subject matter of ethical leadership but until now the matter of developing business students’ ethical leadership competences has been hardly touched. This is one of the gaps to be filled if we want to speak about the Europe of knowledge at all. The purpose of the present study is twofold: to summarize the previous research in the field of ethical leadership and to research Latvian business students’ perception of ethical leadership. Hence the tasks of…
Spanish validation of the Servant Leadership Short Scale for young adults and adolescents / Validación de la Escala de Liderazgo de Servicio Versión …
2017
AbstractThe aim of the current study was to validate a shortened Spanish version of the Servant Leadership Profile (SLP). In Study 1, a number of experts evaluated and reduced the original scale to 14 items and named the revised version the Servant Leadership Short Scale (SLSS). An exploratory factor analysis conducted with a sample of 1,001 students revealed two possible structure solutions, a one-factor solution and a two-correlated factor solution. Study 2 used a different sample of 456 students to examine the explored structures using confirmatory factor analysis. A one-factor solution was proposed (χ2/df = 3.4, CFI = .91, TLI = .90, RMSEA = .07, SRMR = .06). Finally, in Study 3, servan…