Search results for " learning"
showing 10 items of 5299 documents
Interpretable machine learning models for single-cell ChIP-seq imputation
2019
AbstractMotivationSingle-cell ChIP-seq (scChIP-seq) analysis is challenging due to data sparsity. High degree of data sparsity in biological high-throughput single-cell data is generally handled with imputation methods that complete the data, but specific methods for scChIP-seq are lacking. We present SIMPA, a scChIP-seq data imputation method leveraging predictive information within bulk data from ENCODE to impute missing protein-DNA interacting regions of target histone marks or transcription factors.ResultsImputations using machine learning models trained for each single cell, each target, and each genomic region accurately preserve cell type clustering and improve pathway-related gene i…
An evolutionary restricted neighborhood search clustering approach for PPI networks
2014
Protein-protein interaction networks have been broadly studied in the last few years, in order to understand the behavior of proteins inside the cell. Proteins interacting with each other often share common biological functions or they participate in the same biological process. Thus, discovering protein complexes made of a group of proteins strictly related can be useful to predict protein functions. Clustering techniques have been widely employed to detect significant biological complexes. In this paper, we integrate one of the most popular network clustering techniques, namely the Restricted Neighborhood Search Clustering (RNSC), with evolutionary computation. The two cost functions intr…
Proactive Handoff of Secondary User in Cognitive Radio Network Using Machine Learning Techniques
2021
Spectrum management always appears as an essential part of modern communication systems. Handoff is initiated when the signal strength of a current user deteriorates below a certain threshold. In cognitive radio network, the perception of handoff is different due to the presence of two categories of users: certified/primary user and uncertified/secondary user. The reason for the spectrum handoff arises when the primary user (PU) returns to one of its band used by the secondary user. The spectrum handoff is of two types: reactive handoff and proactive handoff. There are certain limitations in reactive handoff, such as it suffers from prolonged handoff latency and interference. In the proacti…
Using proximity and spatial homogeneity in neighbourhood-based classifiers
1997
In this paper, a set of neighbourhood-based classifiers are jointly used in order to select a more reliable neighbourhood of a given sample and take an appropriate decision about its class membership. The approaches introduced here make use of two concepts: proximity and symmetric placement of the samples.
Resolving ambiguities in a grounded human-robot interaction
2009
In this paper we propose a trainable system that learns grounded language models from examples with a minimum of user intervention and without feedback. We have focused on the acquisition of grounded meanings of spatial and adjective/noun terms. The system has been used to understand and subsequently to generate appropriate natural language descriptions of real objects and to engage in verbal interactions with a human partner. We have also addressed the problem of resolving eventual ambiguities arising during verbal interaction through an information theoretic approach.
Network attack detection and classification by the F-transform
2015
We solve the problem of network attack detection and classification. We discuss the way of generation and simulation of an artificial network traffic data. We propose an efficient algorithm for data classification that is based on the F-transform technique. The algorithm successfully passed all tests and moreover, it showed ability to perform classification in an on-line regime.
Protein data condensation for effective quaternary structure classification
2007
Many proteins are composed of two or more subunits, each associated with different polypeptide chains. The number and the arrangement of subunits forming a protein are referred to as quaternary structure. The quaternary structure of a protein is important, since it characterizes the biological function of the protein when it is involved in specific biological processes. Unfortunately, quaternary structures are not trivially deducible from protein amino acid sequences. In this work, we propose a protein quaternary structure classification method exploiting the functional domain composition of proteins. It is based on a nearest neighbor condensation technique in order to reduce both the porti…
A 3D Network Based Shape Prior for Automatic Myocardial Disease Segmentation in Delayed-Enhancement MRI
2021
Abstract Objectives: In this work, a new deep learning model for relevant myocardial infarction segmentation from Late Gadolinium Enhancement (LGE)-MRI is proposed. Moreover, our novel segmentation method aims to detect microvascular-obstructed regions accurately. Material and methods: We first segment the anatomical structures, i.e., the left ventricular cavity and the myocardium, to achieve a preliminary segmentation. Then, a shape prior based framework that fuses the 3D U-Net architecture with 3D Autoencoder segmentation framework to constrain the segmentation process of pathological tissues is applied. Results: The proposed network reached outstanding myocardial segmentation compared wi…
Convolutional Neural Networks for the Identification of Regions of Interest in PET Scans: A Study of Representation Learning for Diagnosing Alzheimer…
2017
When diagnosing patients suffering from dementia based on imaging data like PET scans, the identification of suitable predictive regions of interest (ROIs) is of great importance. We present a case study of 3-D Convolutional Neural Networks (CNNs) for the detection of ROIs in this context, just using voxel data, without any knowledge given a priori. Our results on data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) suggest that the predictive performance of the method is on par with that of state-of-the-art methods, with the additional benefit of potential insights into affected brain regions.
A convolutional neural network framework for blind mesh visual quality assessment
2017
In this paper, we propose a new method for blind mesh visual quality assessment using a deep learning approach. To do this, we first extract visual representative features by computing locally curvature and dihedral angles from each distorted mesh. Then, we determine from these features a set of 2D patches which are learned to a convolutional neural network (CNN). The network consists of two convolutional layers with two max-pooling layers. Then, a multilayer perceptron (MLP) with two fully connected layers is integrated to summarize the learned representation into an output node. With this network structure, feature learning and regression are used to predict the quality score of a given d…