Search results for " life"
showing 10 items of 18406 documents
Att skapa och upprätthålla förtroendeförhållanden i vardagen
2012
Etnologinen tutkimus palvelujen käytöstä ja hyvän arjen rakentumisesta
2014
Oikeuttamisverkostot : miten analysoida julkisissa keskusteluissa esitettyjen oikeutusten keskinäisiä suhteita
2021
Luc Boltanskin ja Laurent Thévenot'n vuonna 1991 kehittämä teoria toiminnan moraalisesta oikeuttamisesta on yksi keskeisistä Pierre Bourdieun jälkeisen "pragmatistisen" sosiologian saavutuksista. Tässä artikkelissa esitetään Boltanskin ja Thévenot'n oikeuttamisteoriaan sekä Eeva Luhtakallion ja Tuomas Ylä-Anttilan kehittämään julkisen oikeuttamisen analyysiin (JOA) perustuva metodi, joka havainnollistaa ja visualisoi moraalisen oikeuttamisen kategorioiden verkostoitumista. Artikkelissa metodia havainnollistetaan New York Timesin ilmastokeskustelua koskevan aineiston avulla, mutta sitä voidaan soveltaa kaikkiin julkisia kiistoja koskeviin tekstiaineistoihin. Se voidaan mieltää diskurssiverko…
Effects of progressive aquatic resistance training on symptoms and quality of life in women with knee osteoarthritis: A secondary analysis.
2020
Abstract Objective: To conduct a secondary analysis to study the effects, those 4 months of aquatic resistance training have on self‐assessed symptoms and quality of life in post‐menopausal women with mild knee osteoarthritis (OA), after the intervention and after a 12‐month follow‐up period. Methods: A total of 87 post‐menopausal volunteer women, aged 60‐68 years, with mild knee OA were recruited in a randomized, controlled, 4‐month aquatic training trial (RCT) and randomly assigned to an intervention (n = 43) and a control (n = 44) group. The intervention group participated in 48 supervised aquatic resistance training sessions over 4 months while the control group maintained their usual l…
La vida imaginaria del científico. El caso del cómic 'The Manhattan Projects'
2014
Aquest article analitza The Manhattan Projects, serie de comics que explica una historia alternativa sobre el fi nal de la Segona Guerra Mundial en que el Projecte Manhattan amaga altres activitats mes relacionades amb la ciencia-fi ccio. Aquest treball analitza la translacio del concepte de vida imaginaria encunyat per Marcel Schwob a la historia de la ciencia en el segle XX.
Liikkuva kuva : muuttuva opetus ja oppiminen
2011
Vins d’appellations et gastronomie régionale. La genèse bourguignonne d’un modèle novateur (années 1920-1930)
2016
Boire du vin au restaurant, le choisir ou le faire choisir en fonction du plat sélectionné, étudier la carte des boissons tout comme le menu, ou encore commenter les domaines et les millésimes, sont des actes totalement intégrés par les amateurs de gastronomie du XXIe siècle. Et même si les associations mets vins tendent à s’internationaliser, déguster un produit local avec un vin du cru reste un moment important pour nombre de personnes souhaitant visiter une région. Cette démarche, si commune aujourd’hui, résulte pourtant d’un processus historique finalement assez récent et dont l’évidence contemporaine n’a rien de manifeste historiquement. En France au début du XXe siècle seulement, et d…
CVB3 VP1 interacts with MAT1 to inhibit cell proliferation by interfering with Cdk-activating kinase complex activity in CVB3-induced acute pancreati…
2021
Coxsackievirus B3 (CVB3) belongs to the genus Enterovirus of the family Picornaviridae and can cause acute acinar pancreatitis in adults. However, the molecular mechanisms of pathogenesis underlying CVB3-induced acute pancreatitis have remained unclear. In this study, we discovered that CVB3 capsid protein VP1 inhibited pancreatic cell proliferation and exerted strong cytopathic effects on HPAC cells. Through yeast two-hybrid, co-immunoprecipitation, and confocal microscopy, we show that Menage a trois 1 (MAT1), a subunit of the Cdk-Activating Kinase (CAK) complex involved in cell proliferation and transcription, is a novel interaction protein with CVB3 VP1. Moreover, CVB3 VP1 inhibited MAT…
Infection-induced chromatin modifications facilitate translocation of herpes simplex virus capsids to the inner nuclear membrane
2021
Herpes simplex virus capsids are assembled and packaged in the nucleus and move by diffusion through the nucleoplasm to the nuclear envelope for egress. Analyzing their motion provides conclusions not only on capsid transport but also on the properties of the nuclear environment during infection. We utilized live-cell imaging and single-particle tracking to characterize capsid motion relative to the host chromatin. The data indicate that as the chromatin was marginalized toward the nuclear envelope it presented a restrictive barrier to the capsids. However, later in infection this barrier became more permissive and the probability of capsids to enter the chromatin increased. Thus, although …
Viral and cellular determinants of hepatitis C virus RNA replication in cell culture.
2003
Studies on the replication of hepatitis C virus (HCV) have been facilitated by the development of selectable subgenomic replicons replicating in the human hepatoma cell line Huh-7 at a surprisingly high level. Analysis of the replicon population in selected cells revealed the occurrence of cell culture-adaptive mutations that enhance RNA replication substantially. To gain a better understanding of HCV cell culture adaptation, we characterized conserved mutations identified by sequence analysis of 26 independent replicon cell clones for their effect on RNA replication. Mutations enhancing replication were found in nearly every nonstructural (NS) protein, and they could be subdivided into at …