Search results for " light"

The effect of spherical aberration on visual performance and refractive state for stimuli and tasks typical of night viewing

2018

Purpose: The aim of this work was to examine the impact of Seidel spherical aberration (SA) on optimum refractive state for detecting and discriminating small bright lights on a dark background. Methods: An adaptive-optics system was used to correct ocular aberrations of cyclopleged eyes and then systematically introduce five levels of Seidel SA for a 7-mm diameter pupil: 0, ± 0.18, and ± 0.36 diopters (D) mm−2. For each level of SA, subjects were required to detect one or resolve two points of light (0.54 arc min diameter) on a dark background. Refractive error was measured by adjusting stimulus vergence to minimize detection and resolution thresholds. Two other novel focusing tasks for si…

Effect of Color on Contrast Sensitivity with Two Different Accommodative Stimuli

1993

We studied the influence of color and accommodation on the contrast sensitivity function (CSF). At the same time, we measured the effect of axial chromatic aberration (ACA) on the CSF. The CSF's of two observers were determined using red, green, blue, and white light, at 5- and 0.5-m viewing distances. At 5 m the CSF's were measured with natural vision and also with lenses which compensated the ACA. Results show that the effect of ACA on the CSF is to reduce the sensitivity to blue with respect to the red. The difference in sensitivity between these two colors is between 50 and 150% and varies with the frequency and the subject. When the ACA is compensated the influence of the color on the …

Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure

2021

The skin is constantly exposed to external and internal factors that disturb its function. In this work, two nanosystems-levan nanoparticles and a surfactin-stabilized nanoemulsion were preserved (tested for microbial growth) and characterized (size, polydispersity, Zeta potential, and stability). The nanosystems were introduced in the model formulations-cream, tonic, and gel, and confirmed by TEM. The analysis showed that nanoemulsion has a spherical morphology and size 220–300 nm, while levan nanoparticles had irregular shapes independently of the use of matrix and with particle size (130–260 nm). Additionally, we examined the antiradical effect of levan nanoparticles and nanoemulsion in …

Response by Uphaus et al to Letter Regarding Article, “NfL (Neurofilament Light Chain) Levels as a Predictive Marker for Long-Term Outcome After Isch…

2019

Serum neurofilament levels reflect outer retinal layer changes in multiple sclerosis

2021

Background: Serum neurofilament light chain (sNfL) and distinct intra-retinal layers are both promising biomarkers of neuro-axonal injury in multiple sclerosis (MS). We aimed to unravel the association of both markers in early MS, having identified that neurofilament has a distinct immunohistochemical expression pattern among intra-retinal layers. Methods: Three-dimensional (3D) spectral domain macular optical coherence tomography scans and sNfL levels were investigated in 156 early MS patients (female/male: 109/47, mean age: 33.3 ± 9.5 years, mean disease duration: 2.0 ± 3.3 years). Out of the whole cohort, 110 patients had no history of optic neuritis (NHON) and 46 patients had a previous…

Thermal aggregation of BSA in trehalose or saccharose solutions

2012

Lysozyme Aggregation Driven by Unfolding: the Role of Metal Ions

2007

Kinetics of gamma-H2AX focus formation upon treatment of cells with UV light and alkylating agents.

2008

Histone H2AX is rapidly phosphorylated in response to DNA double-strand breaks (DSBs) induced by ionizing radiation (IR). Here we show that DNA damage induced by alkylating agents [methyl methanesulfonate (MMS) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)] and ultraviolet light (UV-C) leads to a dose and time dependent accumulation of phosphorylated H2AX (gamma-H2AX). Time course experiments revealed that the number of gamma-H2AX foci reached peak levels 8 hr after MMS or MNNG treatment and declined to almost control values within 24 hr after exposure. Upon UV-C treatment, a biphasic response was observed with a maximum 12 hr after treatment. In 43-3B cells deficient in nucleotide excisi…

Studi greci e latini nell?antica Università di Altamura (1748-1821)

2019

The article tries to highlight, despite the scarse of available documentation, the Greek and Latin studies (language and texts) in the ancient Apulian University in Altamura (1748-1821). Furthermore, on the basis of unpublished archival materials (school registers and student workbooks) it is possible to shed light on the ancient authors explained at school, the teaching methods, and the study practices.

Near infrared light to promote synaptic resilience to Alzheimer’s Disease neuropathology

Alzheimer’s Disease (AD) is a multifactorial neurodegenerative dementia with no curative therapeutic options. One of the earliest impairments in AD triggering cognitive decline is the synaptic dysfunction induced by the selective targeting and interruption of the synaptic region by the small oligomeric form of amyloid beta (Aβ). Recently, the co-presence of Aβ oligomers (Aβo) and tau oligomers (tau-o) at the synapses has been suggested to exacerbate this dysfunction. Therefore, the development of therapeutics aimed at protecting the synapses from the toxic binding of both proteins at the synapses can preserve synaptic health and cognitive function. With this goal in mind, the present study …