Search results for " locali"
showing 10 items of 539 documents
HL7v3 CDA Rel.2 prescription: Localization experience and GP Integration Project
2010
The localization experience for the e-prescription, based on the Health Level Seven Version 3 (HL7v3) Clinical Document Architecture, Release 2 (CDA Rel.2), is presented. As application, we propose a project of General Practitioners Integration with the EHR (Electronic Health Record), implementing the e-prescription, patient summary and other CDA Rel.2 documents. The integration is made possible with HL7v3, the most widely used standard for healthcare information interoperability. The project is in line with the state of the art in the normative referring context for the Italian Healthcare, both at national and regional level (Tuscany Region). Final remarks are drawn, also referring to the …
Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization
2015
Increasing evidence indicates that Liver X Receptors (LXRs) have some anticancer properties. We recently demonstrated that LXR ligands induce colon cancer cell pyroptosis through an LXRβ-dependent pathway. In the present study, we showed that human colon cancer cell lines presented differential cytoplasmic localizations of LXRβ. This localization correlated with caspase-1 activation and cell death induction under treatment with LXR ligand. The association of LXRβ with the truncated form of RXRα (t-RXRα) was responsible for the sequestration of LXRβ in the cytoplasm in colon cancer cells. Moreover t-RXRα was not expressed in normal colon epithelial cells. These cells presented a predominantl…
L'istituzione dei Liberi consorzi di Comuni e delle Città metropolitane in Sicilia, ovvero della specialità vagheggiata
2018
L'istituzione dei liberi Consorzi di Comuni e delle città metropolitane ha impegnato l'Assemblea regionale nella precedente legislatura, senza che sia stata prodotta una disciplina organica, in grado di dare attuazione all'art. 15 dello Statuto tenendo conto anche dei vincoli alla potestà legislativa esclusiva della Regione. Di qui le pronunce della Corte costituzionale. Il saggio esamina la relativa problematica.
Mitochondrial G protein coupled receptor kinase 2 regulates proinflammatory responses in macrophages.
2013
G-protein-coupled receptor kinase 2 (GRK2) levels are elevated in inflammation but its role is not clear yet. Here we show that GRK2 expression is dependent on NFκB transcriptional activity. In macrophages, LPS induces GRK2 accumulation in mitochondria increasing biogenesis. The overexpression of the carboxy-terminal domain of GRK2 (βARK-ct), known to displace GRK2 from plasma membranes, in macrophages induces earlier localization of GRK2 in mitochondria in response to LPS leading to increased mt-DNA transcription, reduced ROS production and cytokines expression. Our study shows the relevance of GRK2 subcellular localization in macrophage’s biology and its potential therapeutic properties i…
Nanoscale distribution of TLR4 on primary human macrophages stimulated with LPS and ATI
2019
Toll-like receptor 4 (TLR4) plays a crucial role in the recognition of invading pathogens. Upon activation by lipopolysaccharides (LPS), TLR4 is recruited into specific membrane domains and dimerizes. In addition to LPS, TLR4 can be stimulated by wheat amylase-trypsin inhibitors (ATI). ATI are proteins associated with gluten containing grains, whose ingestion promotes intestinal and extraintestinal inflammation. However, the effect of ATI vs. LPS on the membrane distribution of TLR4 at the nanoscale has not been analyzed. In this study, we investigated the effect of LPS and ATI stimulation on the membrane distribution of TLR4 in primary human macrophages using single molecule localization m…
A human renal cancer line as a new antigen source for the detection of antibodies to cytoplasmic and nuclear antigens in sera of patients with Wegene…
1991
Autoantibodies directed against cytoplasmic antigens of neutrophils (ANCA), especially proteinase 3 (C-ANCA), have proved to be a useful clinical tool to support the diagnosis or to monitor disease activity in Wegener's granulomatosis (WG). Till now, human neutrophil granulocytes have represented the major antigen source used to detect antibodies in WG by the immunofluorescence technique (IFT). We have tested serum samples of 164 patients with different connective tissue diseases (50 suffering from clinically active WG) performing IFT on a human renal cancer line (SK-RC11) and have found antibodies against the nuclear and cytoplasmic antigens in 39 patients. C-ANCA+ sera displayed a charact…
Apprentissage de modalités auxiliaires pour la localisation basée vision
2018
In this paper we present a new training with side modality framework to enhance image-based localization. In order to learn side modality information, we train a fully convo-lutional decoder network that transfers meaningful information from one modality to another. We validate our approach on a challenging urban dataset. Experiments show that our system is able to enhance a purely image-based system by properly learning appearance of a side modality. Compared to state-of-the-art methods, the proposed network is lighter and faster to train, while producing comparable results.
Exploring translation strategies in video game localization
2012
This paper addresses the issue of video game localisation focusing on the different strategies to be used from the point of view of Translation Studies. More precisely, the article explores the possible relation between the translation approaches used in the field and the different genres or textual typologies of video games. As the narrative techniques and the story lines of video games have become more complex and well-developed, the adaptation of games entails a serious challenge for translators. Video games have evolved into multimodal and multidimensional products and new approaches and insights are required when studying the adaptation of games into different cultures. Electronic ente…
Le scelte strategiche e operative delle banche locali nelle regioni dei distretti tecnologici italiani
2011
Con questo lavoro si intende verificare se si sono manifestati dei cambiamenti associati alla crisi finanziaria globale nelle scelte operative, strategiche e attinenti la natura dell’offerta della particolare categoria di intermediario finanziario rappresentata dalle banche locali. Si cercherà di verificare se quest’ultima tipologia di intermediario, sfruttando i propri punti di forza connessi alla vocazione territoriale delle scelte strategiche incentrate sulla filosofia del relationship lending che pone come valore di riferimento il cliente e di conseguenza alla disponibilità di un portafoglio informativo sulle esigenze del cliente molto più ampio sia stata grado di offrire alla clientela…
Aminopropyltransferases involved in polyamine biosynthesis localize preferentially in the nucleus of plant cells
2012
Plant aminopropyltransferases consist of a group of enzymes that transfer aminopropyl groups derived from decarboxylated S-adenosyl-methionine (dcAdoMet or dcSAM) to propylamine acceptors to produce polyamines, ubiquitous metabolites with positive charge at physiological pH. Spermidine synthase (SPDS) uses putrescine as amino acceptor to form spermidine, whereas spermine synthase (SPMS) and thermospermine synthase (TSPMS) use spermidine as acceptor to synthesize the isomers spermine and thermospermine respectively. In previous work it was shown that both SPDS1 and SPDS2 can physically interact with SPMS although no data concerning the subcellular localization was reported. Here we study the…