Search results for " locali"

Molecular determinants of large cargo transport into the nucleus

2020

Nucleocytoplasmic transport is tightly regulated by the nuclear pore complex (NPC). Among the thousands of molecules that cross the NPC, even very large (>15 nm) cargoes such as pathogens, mRNAs and pre-ribosomes can pass the NPC intact. For these cargoes, there is little quantitative understanding of the requirements for their nuclear import, especially the role of multivalent binding to transport receptors via nuclear localisation sequences (NLSs) and the effect of size on import efficiency. Here, we assayed nuclear import kinetics of 30 large cargo models based on four capsid-like particles in the size range of 17–36 nm, with tuneable numbers of up to 240 NLSs. We show that the requireme…

Patterns of oncogene co-expression at single cell resolution in cancer influence survival

2020

AbstractBackgroundCancers often overexpress multiple clinically relevant oncogenes. However, it is not known if multiple oncogenes within a cancer combine uniquely in specific cellular sub-populations to influence clinical outcome. We studied this phenomenon using the prognostically relevant oncogenes MYC, BCL2 and BCL6 in Diffuse Large B-Cell Lymphoma (DLBCL).MethodsQuantitative multispectral imaging simultaneously measured oncogene co-expression at single-cell resolution in reactive lymphoid tissue (n=12) and four independent cohorts (n=409) of DLBCL. Mathematically derived co-expression phenotypes were evaluated in DLBCLs with immunohistochemistry (n=316) and eight DLBCL cohorts with gen…

Unveiling two-dimensional discrete quantum walks dynamics via dispersion relations

2011

The discrete, or coined, quantum walk (QW) [1] is a process originally introduced as the quantum counterpart of the classical random walk (RW). In both cases there is a walker and a coin: at every time step the coin is tossed and the walker moves depending on the toss output. Unlike the RW, in the QW the walker and coin are quantum in nature what allows the coherent superpositions right/left and head/tail happen. This feature endows the QW with outstanding properties, such as making the standard deviation of the position of an initially localized walker grow linearly with time t, unlike the RW in which this growth goes as t1/2. This has strong consequences in algorithmics and is one of the …

Parametric self-trapping in the presence of randomized quasi phase matching

2010

We report on experimental evidence of parametric spatial solitons in a quadratic crystal with randomized periodic ferroelectric poling. Two-color self-focusing via quadratic cascading overcomes the diffractive nature of both fundamental and frequency-doubled beams.

RSS-eye: Human-assisted Indoor Localization without Radio Maps

2015

The pervasive diffusion of smartphones is boosting indoor positioning solutions and location-based services. We propose a novel methodology to perform indoor positioning of mobile users by the estimation of angles of arrival from access points whose locations are known. Angles of arrival are estimated by correlating WiFi RSSI measurements with data coming from a digital compass, which is provided by most current handsets. Our system has minimal requirements in terms of infrastructure and mobile hardware. The system neither needs calibration, nor radio maps but requires the user to perform a gesture when an estimation is needed. The resulting on-demand localization has advantages in terms of…

ANALYSIS OF THE SEXUAL VARIABILITY IN THE SHELL OF THE SPANISH UPPER CRETACEOUS TURTLE DORTOKA VASCONICA (PAN-PLEURODIRA, DORTOKIDAE)

2021

The present study characterizes the morphological variability related to the sexual dimorphism in the shells of the Spanish Upper Cretaceous turtle  Dortoka vasconica . This study is based on the material from its type locality: Lano, Burgos. Two morphotypes were identified there based on the posterior plastral area as well as two for the anterior plastral lobe. However, a correlation with the previously indicated morphotypes could not be established due to the disarticulation of the specimens and the limited information available on the sexual dimorphism of Pleurodira. The morphological variability previously identified for  Dortoka vasconica  is analysed here through a quantitative approa…

α1-Adrenoceptors in the rat cerebral cortex: New insights into the characterization of α1L- and α1D-adrenoceptors

2010

36 p., figuras y tablas, bibliografía

Towards an Understanding of the Polar Diels–Alder Reactions of Nitrosoalkenes with Enamines: A Theoretical Study

2006

The polar Diels–Alder reactions of nitrosoalkenes with enamines have been studied using DFT methods at the B3LYP/6-31G* level of theory. These Diels–Alder reactions are characterized by a nucleophilic attack of the enamine at the conjugated position of the nitrosoalkene with concomitant ring-closure. The reactions present a total regioselectivity and a large endo selectivity. The analysis, based on the global electrophilicity of the reagents in the ground state, the natural bond orbital (NBO), and the topological analysis of the electron localization function (ELF) in the endo transition state (TS) and “halfway” along the IRC between the TS and cycloadduct, correctly explain the polar natur…

Recensione al volume di Isabella Bolgiani, Regioni e fattore religioso. Analisi e prospettive normative, Milano, Vita e Pensiero, 2012

2012

La responsabilità dirigenziale tra Stato ed Enti locali

2018

Qual è il rilievo, il ruolo e la finalità della responsabilità dirigenziale nel sistema delle responsabilità pubbliche e nel contesto dei variegati rapporti, a livello statale e locale, tra organi di indirizzo politico ed organi dirigenziali? Qual è la vera natura della responsabilità dirigenziale rispetto alle altre forme di responsabilità del dirigente? Quali sono i suoi tratti caratterizzanti, i suoi presupposti, le criticità e le soluzioni alternative? Quali sono, infine, le garanzie procedimentali e gli strumenti di tutela in favore del dirigente contro i provvedimenti sanzionatori conseguenti alla responsabilità dirigenziale? Questi sono gli interrogativi ai quali il lavoro intende ri…