Search results for " low"
showing 10 items of 972 documents
Prueba de Lowenberg
2010
Prueba de Lowenberg como prueba funcional en la valoración del sistema venoso.
EXTERNAL RECIRCULATION IN PRS TYPE TURBINE: EXPERIMENTAL AND NUMERICAL RESULTS.
2022
Cavitation is a relevant phenomenon for structural safety and noise level in hydraulic turbines, occurring when water pressure falls below the vapor value at a given temperature. In this case bubbles of vapor grow inside the liquid and move along with it. When the pressure returns above the vapor value the bubble collapses, and the pressure can locally achieve very high values, up to 7000 bars (Kumar & Saini, 2010). Moreover, if the bubble was confined also by the solid wall of a blade, the solid particles suspended in the fluid can be transported by the fluid ones and hit the solid wall at very high velocity, generating erosion. Cavitation is also the source of high frequency noise, ve…
On singular integral and martingale transforms
2007
Linear equivalences of norms of vector-valued singular integral operators and vector-valued martingale transforms are studied. In particular, it is shown that the UMD(p)-constant of a Banach space X equals the norm of the real (or the imaginary) part of the Beurling-Ahlfors singular integral operator, acting on the X-valued L^p-space on the plane. Moreover, replacing equality by a linear equivalence, this is found to be the typical property of even multipliers. A corresponding result for odd multipliers and the Hilbert transform is given.
Thermomineral waters of Greece: geochemical characterization
2020
Investigation of the p–Σ0 interaction via femtoscopy in pp collisions
2020
This Letter presents the first direct investigation of the p-$\Sigma^{0}$ interaction, using the femtoscopy technique in high-multiplicity pp collisions at $\sqrt{s}$ = 13 TeV measured by the ALICE detector. The $\Sigma^{0}$ is reconstructed via the decay channel to $\Lambda \gamma$, and the subsequent decay of $\Lambda$ to p$\pi^-$. The photon is detected via the conversion in material to e$^{+}$e$^{-}$ pairs exploiting the unique capability of the ALICE detector to measure electrons at low transverse momenta. The measured p-$\Sigma^{0}$ correlation indicates a shallow strong interaction. The comparison of the data to several theoretical predictions obtained employing the $Correlation~Anal…
Polyoxypregnanes as safe, potent, and specific ABCB1-inhibitory pro-drugs to overcome multidrug resistance in cancer chemotherapy in vitro and in vivo
2021
Multidrug resistance (MDR) mediated by ATP binding cassette subfamily B member 1 (ABCB1) is significantly hindering effective cancer chemotherapy. However, currently, no ABCB1-inhibitory drugs have been approved to treat MDR cancer clinically, mainly due to the inhibitor specificity, toxicity, and drug interactions. Here, we reported that three polyoxypregnanes (POPs) as the most abundant constituents of Marsdenia tenacissima (M. tenacissima) were novel ABCB1-modulatory pro-drugs, which underwent intestinal microbiota-mediated biotransformation in vivo to generate active metabolites. The metabolites at non-toxic concentrations restored chemosensitivity in ABCB1-overexpressing cancer cells v…
Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.
2022
Funder: European Commission
Clinical evaluation of bempedoic acid for the treatment of hyperlipidaemia.
2021
Bempedoic acid (BA) is a novel first-in-class oral lipid-lowering therapy. BA has been approved by the European Medicinal Agency and Food and Drug Administration and has been commercialised throughout Europe since the end of 2020 as an add-on therapy in patients at high/very-high cardiovascular risk that are not at LDL-C goals with current lipid-lowering treatments. Recently, Italian lipid management experts gathered to discuss several open questions on BA characteristics and BArelated practical clinical issues. The panel permitted collection of its opinions in a ten Q&A format. Aim: The aim of this viewpoint is to discuss and answer several open questions on BA characteristics and BA-r…
NEW THERAPEUTIC PERSPECTIVES IN IRRITABLE BOWEL SYNDROME: TARGETING LOW-GRADE INFLAMMATION, IMMUNO-NEUROENDOCRINE AXIS, MOTILITY, SDECRETION AND BEYO…
2017
Irritable bowel syndrome (IBS) is a chronic, recurring, and remitting functional disorder of the gastrointestinal tract characterized by abdominal pain, distention, and changes in bowel habits. Although there are several drugs for IBS, effective and approved treatments for one or more of the symptoms for various IBS subtypes are needed. Improved understanding of pathophysiological mechanisms such as the role of impaired bile acid metabolism, neurohormonal regulation, immune, dysfunction, the epithelial barrier and the secretory properties of the gut has led to advancements in the treatment of IBS. With regards to therapies for restoring intestinal permeability, multiple studies with prebiot…
Abelian integrals and limit cycles
2006
Abstract The paper deals with generic perturbations from a Hamiltonian planar vector field and more precisely with the number and bifurcation pattern of the limit cycles. In this paper we show that near a 2-saddle cycle, the number of limit cycles produced in unfoldings with one unbroken connection, can exceed the number of zeros of the related Abelian integral, even if the latter represents a stable elementary catastrophe. We however also show that in general, finite codimension of the Abelian integral leads to a finite upper bound on the local cyclicity. In the treatment, we introduce the notion of simple asymptotic scale deformation.