Search results for " malattie."
showing 10 items of 1941 documents
Long Term Results of Stanford V Regimen and Highly Active Antiretroviral Therapy (HAART) In 59 Patients (pts) with HD and HIV Infection (HD-HIV)
2010
Abstract Abstract 4827 Background: The introduction of HAART has significantly improved the outcome of pts with HD-HIV. However there are no data on the long term follow-up of HD-HIV pts treated with conventional chemotherapy (CT) regimens. In 2002, we reported the results of a prospective phase II study with the intensive 12-week CT with adjuvant radiotherapy (Stanford V) and concomitant HAART in 59 pts (Spina et al. Blood 2002;100:1984-1988). Methods: To analyze the long term outcome of patients included in the Stanford V and HAART protocol. Results: The median follow-up is 67months (range 3–156 months The 5-yr overall survival (OS), freedom from progression (FFP), disease free survival a…
A return to humane medicine: Osler's legacy.
2017
Sir William Osler is celebrated today not only for his contributions to the advancement of medical education, but also for the humanism he brought to the practice of medicine. He was a doctor whose bedside skills and manners were emulated, and can legitimately be called an infectious diseases specialist. Nonetheless, he was also a humanist in the broader sense of the term, a student of human affairs and human nature, who emphasised compassion for the individual. To what extent, if any, are today's challenges influenced by departures from the paradigms created by Osler? In this paper we sought to ascertain whether such a tradition is still relevant to current practice and may foster a new pe…
Thinking about ophthalmology in the era of the COVID-19 pandemic
2020
There is no part of the health care system that has remained unscathed by the COVID-19 pandemic in terms of its organizational, scientific or medical models. The surgical specialities were called upon to analyse the concepts of urgency and deferrable, reconsider the procedures and the times for those, and to evaluate new and specific strategies for the remote and safe management of patients. The aim of this paper is to evaluate new and different approaches in the field of ophthalmology triggered by the COVID-19 emergency. We analysed literature and on line documents; key words for the research were: SARS-CoV-2, COVID-19, ophthalmology, ophthalmologist, eye, guidelines, and their combination…
Optical coherence tomography as a simple and non invasive tool for the diagnosis of oral disease: a case report
2015
Introduction. Optical Coherence Tomography (OCT) is a new biomedical imaging modality that provides high reso- lution cross-sectional images of tissue. Conceptually, it has been compared with ultrasound scanning but it uses in- frared light and records reflections below the surface to produce a cross-sectional architectural image of the tissue. OCT has been applied in ophthalmology and recently in dermatology; several studies have shown the validity of the use of OCT in ex vivo oral lesions but, to date, it does not exist a bank of normative and pathological OCT data of the oral tissues to consent identification of cellular structures of normal and pathological processes. We report a case o…
Angiogenesis of oral lichen planus: a possible pathogenetic mechanism.
2008
Objective: Oral Lichen Planus (OLP) is a chronic inflammatory disease with an autoimmune inflammatory pathogenesis. The aim of the research is to compare the vascular endothelial growth factor (VEGF) and adhesion of molecules in the biopsy samples of patients affected by OLP, in order to research the presence of the angiogenetic phenomenon and to understand its pathogenetic mechanism. Materials and Methods: Thirty OLP patients and thirty healthy subjects were enrolled in a study. The immunohistochemical analysis of the VEGF and vascularendothelial adhesion molecules was carried out by means of primary antibodies and anti-CD34, anti-VEGF, antiCD106 antigen (VCAM-1) and anti-CD54 antigen (ICA…
Oral Pathology and Oral Medicine
2015
This is a multidisciplinary publication for all fields of oral medicine. This book builds a bridge between basic and clinical sciences, promoting the exchange of information and the advancement of oral medicine for the benefit of patients and clinicians. It offers comprehensive coverage of new techniques, important developments, and innovative ideas in all fields of clinical dentistry.
Oral amelanotic melanoma: a case report
2014
Objectives. Primary oral melanoma is a very rare malignancy, representing about 0.5% of all melanomas, characterized by a wide clinical-histological variability and a very aggressive behavior. Aim of the present study is to describe a case of oral amelanotic melanoma, an infrequent variant with a poorer prognosis than that of pigmented melanomas for a more aggressive biological behavior and frequent delays for the correct diagnosis and for starting the treatment. Case report. A 53-year-old white man referred at the Department Surgical, Oncological and Oral Sciences for a macular, scarsely pigmented lesion with irregular margins, located on anterior region of hard palate. The lesion, complet…
Not a current fashion, but a truth since 1884
2011
We thank Kucharz [1] for the valuable historical comment to our review focusing on the role of oral infection on systemic diseases [2]. The majority of scientists today write and read the English language whereas articles in Polish and German are scarcely known outside of Poland and Germany, respectively. For these reasons, the contribution of Kaczorowsky [3] is commonly forgotten in medical literature, but the letter of Kurchaz properly acknowledges this pioneer researcher in the periodontal medicine. We also thank Blum [4] for adding his results [5,6] to our review article. As the number of references citable is limited, we did not cite the articles written by Blum et al. [5,6], but we re…
Changes of oral microcirculation in chemotherapy patients: A possible correlation with mucositis?
2014
The aim of this investigation is to appraise labial oral microcirculation in chemotherapy patients to clarify the effects of cytotoxic agents on oral microvessels. Twenty-five patients with diagnosis of head and neck tumors were recruited in the study. All the patients were submitted to chemotherapy. Labial oral microcirculation was evaluated on labial mucosa using oral videocapillaroscopy. The statistical significance was checked with the Mann-Whitney U-test (P < 0.05). The analysis of videocapillaroscopic patterns showed statistically significant variations relative to the diameter of the incoming loop; the diameter of the outgoing loop; and loop tortuosity. This study shows that capillar…
Prevention and the treatment of oral mucositis: the efficacy of sodium bicarbonate vs other agents: a systematic review
2023
Abstract Introduction Oral mucositis (OM) is a major side effect of cancer therapy, which is associated with significant symptoms, treatment delays and increased costs for the health system. It is an important component of the quality of life of cancer patients and, until now, there has been no gold standard regarding prevention or treatment of this pathology. Notwithstanding the paucity of treatment guidelines (due to limited evidence from high-quality, rigorous studies), sodium bicarbonate (SB) rinses are one of the most used agents for OM management. Objectives A systematic review (2000–2022) was performed in order to compare and examine different agents versus sodium bicarbonate (SB) in…