Search results for " medicinal"

Acclimatization, distribution and potential economic use of Argania spinosa (Sapotaceae) in southern Italy

2021

The authors report updated notes on the acclimatization, distribution, areas suitable for cultivation and, potential use of Argania spinosa (Sapotaceae) in southern Italy. Based on observations carried out on the plants cultivated in Bari and the Botanical Garden of Palermo, and on ecological requirements of the species it is possible to consider A. spinosa as a woody species easily adaptable to the coastal climate of southern Italy.

Una storia che viene da lontano

2017

La fitoterapia, cioè la cura delle malattie per mezzo dei vegetali, ha rappresentato il metodo utilizzato fin dall'antichità per alleviare le sofferenze e a volte curare o risolvere reali patologie mediante l’impiego di parti di piante fresche o essiccate o dei loro estratti naturali. Come si evince da questo breve excursus storico, in tutti i continenti, tutte le civiltà si sono dedicate, oltre che alla coltura di piante a scopo alimentare, alla ricerca di piante con proprietà terapeutiche. E’ straordinariamente interessante come, attraverso i millenni, l’insieme di queste nozioni si sia arricchito, e anche diversificato, senza essere mai interamente dimenticato.

Stroke as a target in medicinal chemistry and drug discovery.

2009

Avance sobre la flora medicinal en la Sierra de Mariola (Valencia-Alicante)

2004

Se han estudiado las diferentes especies medicinales que presentan mayor popularidad en la Sierra de Mariola (Alicante-Valencia, España). Se han identificado un total de 67 especies botánicas en 9 entrevistas realizadas, encontrándose una clara dominancia de las especies pertenecientes a las familias Labiatae y Compositae. The most well-known medicinal species from Sierra Mariola (Alicante-Valencia, Spain) were studied. After nine interviews, 67 botanical species were identified, most of them belonging to Labiatae and Compositae.

The role played by doctors, the Government and the who in the implementation of poliomyelitis, measles and rubella serological surveys in Spain (1958…

2020

Serological surveys, which acquired considerable importance in the mid twentieth century, are still a key tool to address infectious diseases. This article, using archival and printed sources from the WHO and the medical and general press, analyses the role of doctors and scientists, government, and the WHO in the implementation of serological surveys to evaluate the situation of poliomyelitis, measles and rubella in Spain and to set up a plan of action against them. The paper shows the role of Florencio Pérez Gallardo and his group at the National School of Health, favoured by the Franco regime to receive the support of WHO collaborative programmes after Spain joined in 1951, and the impac…

Identification of Three-Way DNA Junction Ligands through Screening of Chemical Libraries and Validation by Complementary in Vitro Assays

2019

International audience; The human genome is replete with repetitive DNA sequences that can fold into thermodynamically stable secondary structures such as hairpins and quadruplexes. Cellular enzymes exist to cope with these structures whose stable accumulation would result in DNA damage through interference with DNA transactions such as transcription and replication. Therefore, the chemical stabilization of secondary DNA structures offers an attractive way to foster DNA transaction-associated damages to trigger cell death in proliferating cancer cells. While much emphasis has been recently given to DNA quadruplexes, we focused here on three-way DNA junctions (TWJ) and report on a strategy t…

Metabolomics analysis and biological investigation of three Malvaceae plants

2019

Introduction: Metabolomics is a fast growing technology that has effectively contributed to many plant-related sciences and drug discovery. Objective: To use the non-targeted metabolomics approach to investigate the chemical profiles of three Malvaceae plants, namely Hibiscus mutabilis L. (Changing rose), H. schizopetalus (Dyer) Hook.f. (Coral Hibiscus), and Malvaviscus arboreus Cav. (Sleeping Hibiscus), along with evaluating their antioxidant and anti-infective potential. Methodology: Metabolic profiling was carried out using liquid chromatography coupled with high-resolution electrospray ionisation mass spectrometry (LC-HR-ESI-MS) for dereplication purposes. The chemical composition of th…

LC–ESI–FT–MSn Metabolite Profiling of Symphytum officinale L. Roots Leads to Isolation of Comfreyn A, an Unusual Arylnaphthalene Lignan

2020

Preparations of comfrey (Symphytum officinale L.) roots are used topically to reduce inflammation. Comfrey anti-inflammatory and analgesic properties have been proven in clinical studies. However, the bioactive compounds associated with these therapeutic activities are yet to be identified. An LC&ndash

Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action

2019

Abstract New compounds able to counteract staphylococcal biofilm formation are needed. In this study we investigate the mechanism of action of pyrrolomycins, whose potential as antimicrobial agents has been demonstrated. We performed a new efficient and easy method to use microwave organic synthesis suitable for obtaining pyrrolomycins in good yields and in suitable amount for their in vitro in-depth investigation. We evaluate the inhibitory activity towards Sortase A (SrtA), a transpeptidase responsible for covalent anchoring in Gram-positive peptidoglycan of many surface proteins involved in adhesion and in biofilm formation. All compounds show a good inhibitory activity toward SrtA, havi…

Antibacterial Activity of Desert Truffles from Saudi Arabia Against Staphylococcus aureus and Pseudomonas aeruginosa

2017

Abstract Medicinal mushrooms represent an unlimited source of polysaccharides with nutritional, antitumoral, antibacterial, and immune-stimulating properties. Traditional studies of epigeous higher Basidiomycetes have recently been joined by studies of hypogeous fungi and, in particular, of so-called desert truffles. With the aim to obtain novel agents against bacteria of clinical importance, we focused on the edible desert truffle mushrooms Tirmania pinoyi, Terfezia claveryi, and Picoa juniperi as sources of new antimicrobial agents. In particular, we investigated the in vitro antibacterial activity of acid-soluble protein extracts (aqueous extracts) of these 3 species against the Gram-pos…