Search results for " mellitus"

Continuous subcutaneous Insulin infusion leads to immediate, table, and long-term changes in metabolic control

2008

Background:  Evaluations of continuous subcutaneous insulin infusion (CSII) usually focus on one pre- and one post-CSII measurement to assess metabolic therapy outcome. Aim:  Extending this research, the aim of the present study was to provide a more fine-grained analysis of achieved glycaemic control. Methods:  In 52 patients with type 1 diabetes (mean age of 37.85 years at CSII begin; s.d. ± 12.41), haemoglobin A1c (HbA1c) levels were assessed every 3 months over a period of 5 years (1 year before and 4 years after the introduction of CSII). Mixed models were utilized to describe changes in glycaemic control. Results:  The pre–post course showed that already in the first quarter, a statis…

Análisis del la relación del genotipado y marcadores de estrés oxidativo con la presencia y grado de vasculopatía periférica en pacientes con diabete…

2014

RESUMEN: Padecer diabetes tipo 2 (DM2) ejerce un efecto independiente y multiplicador en la incidencia de complicaciones vasculares, añadido a la presencia de factores de riesgo clásicos. No todos los diabéticos desarrollan con la misma gravedad la vasculopatía periférica (VP). Este riesgo está presente en la fase de prediabetes, donde las complicaciones vasculares pueden preceder a la aparición de la propia diabetes. La biología vascular ha puesto de manifiesto la participación de otros factores como el estrés oxidativo (EO) y el estado crónico inflamatorio en el incremento de este riesgo. Los principales sistemas conocidos de EO a nivel endotelial generan especies reactivas de oxígeno. Pa…

Availability of psychological care in pediatric diabetes centers – a real need?

2023

Rolę multidyscyplinarnego zespołu diabetologicznego w leczeniu osoby z cukrzycą podkreślają zarówno polskie, jak i międzynarodowe zalecenia. Znaczenie dostępności opieki psychologicznej dla samopoczucia i zdrowia psychicznego osób z cukrzycą (i ich opiekunów), a także dla wyników leczenia cukrzycy jest przedmiotem licznych analiz. Pomimo rekomendacji i badań pokazujących korzyści z interwencji i wsparcia psychologicznego, brakuje danych na temat rzeczywistej dostępności takiej opieki zarówno w Polsce, jak i na świecie.

Association between Serum Osteoprotegerin Levels and Severity of Coronary Artery Disease in Patients with Acute Myocardial Infarction

2021

International audience; Background. Osteoprotegerin (OPG), a glycoprotein of the tumour necrosis factor (TNF) superfamily, is one of the main biomarkers for vascular calcification. Aim. We aimed to evaluate the association between serum OPG levels and extent of coronary lesions in patients with acute myocardial infarction (MI). Methods. Consecutive patients hospitalized for an acute MI who underwent coronary angiography were included. SYNTAX score was calculated to assess the severity of coronary artery disease. The population was analysed in low (5 (3–6)), medium (11 (9–13)) and high (20 (18–23)) tertiles of SYNTAX score. Results. Among the 378 patients included, there was a gradual increa…

Management of Statin Intolerance in 2018: Still More Questions Than Answers.

2018

Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutra…

Three-year mortality after acute myocardial infarction in patients with different diabetic status

2021

Introduction: The prevalence of diabetes mellitus (DM) in patients with myocardial infarction (MI) is estimated at about 25%. Short and long-term prognoses are worse in DM and hyperglycemia compared with non-diabetics. Objectives: Our aim was to analyze the impact of DM and transient hyperglycemia on in-hospital complications and long-term outcomes in MI patients. Patients and Methods: We evaluated a prospective cohort of 58,394 MI patients in the Polish Registry of Acute Coronary Syndrome in terms of in-hospital complications and 30-day, 12-month, and 36-month outcomes between 2009–2012. Results: Type 1 and 2 DM patients underwent invasive diagnostic and therapeutic procedures less frequen…

Serum metabolic profiles in overweight and obese women with and without metabolic syndrome.

2014

Objective: To identify serum biomarkers through metabolomics approach that distinguishes physically inactive overweight/obese women with metabolic syndrome from those who are metabolically healthy, independent of body weight and fat mass. Methods: We applied nuclear magnetic resonance spectroscopy-based profiling of fasting serum samples to examine the metabolic differences between 78 previously physically inactive, body weight and fat mass matched overweight/obese premenopausal women with and without MetS. MetS was defined as the presence of at least three of the following five criteria: waist circumference ≥ 88 cm, serum triacylglycerol ≥ 1.7 mmol/L, and high density lipoprotein cholester…

Verbal and academic skills in children with type 1 diabetes

2011

Anthropometric Indicators as a Tool for Diagnosis of Obesity and Other Health Risk Factors: A Literature Review

2021

[EN] Obesity is characterized by the accumulation of an excessive amount of fat mass (FM) in the adipose tissue, subcutaneous, or inside certain organs. The risk does not lie so much in the amount of fat accumulated as in its distribution. Abdominal obesity (central or visceral) is an important risk factor for cardiovascular diseases, diabetes, and cancer, having an important role in the so-called metabolic syndrome. Therefore, it is necessary to prevent, detect, and appropriately treat obesity. The diagnosis is based on anthropometric indices that have been associated with adiposity and its distribution. Indices themselves, or a combination of some of them, conform to a big picture with di…

New developments in the pathogenesis of obesity-induced hypertension

2015

Obesity is a disorder that develops from the interaction between genotype and environment involving social, behavioral, cultural, and physiological factors. Obesity increases the risk for type 2 diabetes mellitus, hypertension, cardiovascular disease, cancer, musculoskeletal disorders, chronic kidney and pulmonary disease. Although obesity is clearly associated with an increased prevalence of hypertension, many obese individuals may not develop hypertension. Protecting factors may exist and it is important to understand why obesity is not always related to hypertension. The aim of this review is to highlight the knowledge gap for the association between obesity, hypertension, and potential …