Search results for " mellitus"
showing 10 items of 2078 documents
Intermittent Fasting and the Possible Benefits in Obesity, Diabetes, and Multiple Sclerosis: A Systematic Review of Randomized Clinical Trials
2021
Intermittent fasting has become popular in recent years and is controversially presented as a possible therapeutic adjunct. A bibliographic review of the literature on intermittent fasting and obesity, diabetes, and multiple sclerosis was carried out. The scientific quality of the methodology and the results obtained were evaluated in pairs. Intermittent fasting has beneficial effects on the lipid profile, and it is associated with weight loss and a modification of the distribution of abdominal fat in people with obesity and type 2 diabetes as well as an improvement in the control of glycemic levels. In patients with multiple sclerosis, the data available are too scarce to draw any firm con…
Melatonin Concentrations and Sleep Quality in Patients with Type 2 Diabetes and Obesity
2019
Abstract There is a close relationship between melatonin as a circadian regulator and insulin, glucagon and somatostatin production. This study aimed to describe subgroups of type 2 diabetes mellitus (T2DM) patients that may benefit from melatonin clock-targeting properties. The study involved 38 participants: 26 T2DM patients, and 12 participants without diabetes in the control group. Subjects were asked to complete the questionnaire of Pittsburgh Sleep Quality Index (PSQI). Standard biochemical venous sample testing was performed, and a sample of saliva was collected for melatonin testing. Melatonin concentration in participants without obesity (body mass index (BMI) < 30 kg/m2) was si…
Obesity and diabetes-Not only a simple link between two epidemics
2018
Summary Diabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization. Obesity is involved not only in the aetiopathogenesis of the most common worldwide type of DM—type 2 diabetes—but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes. Weight gain may be considered as a complication of insulin treatment but also reveals significant pathophysiological impact on various stages of the disease. Another very important aspect related to DM as well as obesity is the microbiome, which is highly variable. The function of the gut …
Fluctuaciones refractivas en la diabetes mellitus. Implicaciones en la praxis optométrica
2014
El objetivo de este trabajo se centra en cómo los niveles de glucosa en sangre en personas que padecen de diabetes mellitus, afecta a la fluctuación refractiva del ojo, y cuáles pueden ser las implicaciones en la praxis optométrica. Para lograr este objetivo, se ha llevado a cabo una investigación de tipo documental basada en la revisión y el análisis de la literatura científica general y específica existente sobre la temática. Se ha analizado cómo la glucemia afecta a las diferentes partes del ojo de una forma independiente, a corto y a largo plazo. El trabajo se ha estructurado en varios apartados donde se abordan las siguientes temáticas: relevancia de la enfermedad en el mundo, resumen …
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
2013
Recent genome-wide association studies have linked type-2 diabetes mellitus to a genomic region in chromosome 9p21 near the Ink4/Arf locus, which encodes tumor suppressors that are up-regulated in a variety of mammalian organs during aging. However, it is unclear whether the susceptibility to type-2 diabetes is associated with altered expression of the Ink4/Arf locus. In the present study, we investigated the role of Ink4/Arf in age-dependent alterations of insulin and glucose homeostasis using Super-Ink4/Arf mice which bear an extra copy of the entire Ink4/Arf locus. We find that, in contrast to age-matched wild-type controls, Super-Ink4/Arf mice do not develop glucose intolerance with agi…
Evaluación de los signos precoces de aterosclerosis en niños con Diabetes Mellitus tipo 1
2015
INTRODUCCIÓN La Diabetes Mellitus tipo 1 (DM1) representa un importante factor de riesgo de enfermedad cardiovascular. La ecografía de la arteria carótida común derecha se ha establecido como una técnica útil y fiable para valorar la presencia de cambios ateroscleróticos subclínicos. Estos signos precoces se manifiestan con el aumento del índice grosor íntima-media carotídeo (GIMc). Previamente a esta alteración estructural, se afecta la función endotelial, que se valora mediante la estimación de los parámetros de rigidez arterial. OBJETIVOS Evaluar el GIMc y los índices de rigidez arterial, en una población de niños con DM1, en comparación con una población de niños sanos, de similares eda…
Ohjauksen kirjaaminen : tyypin 2 diabetespotilaiden omahoito ja osaaminen potilasasiakirjoissa
2017
The purpose of this study was to describe the contents of type 2 diabetes patient self-management counselling documentation, how counselling of self- management appeared in various content areas and how patients’ self- management competence developed during the counselling. The research data consisted of nurses’ documentations from type 2 diabetes patient self- management counselling situations (N = 60) in primary health care. The data was collected in 2014 from the period between the years 2005 and 2014. Data were analyzed using content analysis as well as a case study approach. The documentation of self-management counselling included entries from content areas on nutrition, exercise, wei…
Comparative analysis of socioeconomic, behavioral and biological factors between healthy patients and patients with newly diagnosed diabetes in the L…
2020
Introduction. The most effective way to prevent a dramatic increase in the number of diabetic patients lies in early detection of its risk factors and the diagnosis of carbohydrate metabolism disorders. Aim of the study. The study aims at determining socio-economic variables, lifestyle behaviours and biological factors differentiating patients with newly diagnosed diabetes from the diabetes-free individuals according to the American criteria issued by the Commission on Social Determinants of Health as well as FINDRISC form which helps identify patients who are at risk of developing diabetes type 2 on the basis of multi-factorial determinants of its development. Material and methods. The res…
Diabēta medikamentu blakusparādības
2016
Ievads: Vēljoprojām ir sastopamas nozīmīgas blaknes diabēta zālēm, kas ir īpaši nozīmīgi pieaugot saslimstībai ar diabētu pasualē, kā arī Latvijā. Atpazīt diabēta medikamentu izraisītās blaknes ir svarīgi, lai novērstu smagās komplikācijas, ko tās var radīt. Pētijuma mērķis: pētījuma mērķis bija konstatēt blakņu esamību hospitalizētajiem diabēta pacientiem. Materiāli un Metodes: pētījumi, iekļāva pacientus, kuri diagnozticēti ar diabetes mellitus. Pacienti tika iztaujāti par medikamentiem, kurus viņi lieto atveseļošanās periodā un par viņu zināmām vai nezināmajām novērotajām blaknēm. Rezultāti: Pētījumā tika iekļauti 50 pacienti, ar abu, 1. un 2. tipa diabētiem. Pētāmo pacientu grupa sastāv…
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…