Search results for " meta"
showing 10 items of 9626 documents
The origin of heavy metals and radionuclides accumulated in the soil and biota samples collected in Svalbard, near Longyearbyen
2017
Heavy metals and radioactive compounds are potentially hazardous substances for plants, animals and humans in the Arctic. A good knowledge of the spatial variation of these substances in soil and primary producers, and their sources, is therefore essential. In the samples of lichen Thamnolia vermicularis, Salix polaris and Cassiope tetragona, and the soil samples collected in 2014 in Svalbard near Longyearbyen, the concentrations of the following heavy metals were determined: Mn, Ni, Cu, Zn, Cd, Pb and Hg, as well as the activity concentrations of the following: K-40, Cs-137, Pb-210, Pb-212, Bi-212, Bi-214, Pb-214, Ac-228, Th-231 and U-235 in the soil samples. The differences in the concent…
Value of Combined PET Imaging with [18F]FDG and [68Ga]Ga-PSMA-11 in mCRPC Patients with Worsening Disease during [177Lu]Lu-PSMA-617 RLT
2021
Despite the promising results of prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) in metastatic castration-resistant prostate cancer (mCRPC), some patients show worsening disease during PSMA-RLT. We investigated the value of combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging in this setting. In n = 29 mCRPC patients with worsening disease after a median of four cycles of [177Lu]Lu-PSMA-617 RLT, combined [18F]FDG and [68Ga]Ga-PSMA-11 PET imaging was performed to detect [18F]FDG-avid lesions with low or no PSMA expression (mismatch lesions). To evaluate prognostic implication of mismatch, survival analyses regarding presence, location, and [18F]FDG PET-derived para…
Strongly Coupled Coherent Phonons in Single-Layer MoS 2
2019
We present a transient absorption setup combining broadband detection over the visible-UV range with high temporal resolution ($\sim$20fs) which is ideally suited to trigger and detect vibrational coherences in different classes of materials. We generate and detect coherent phonons (CPs) in single layer (1L) MoS$_2$, as a representative semiconducting 1L-transition metal dichalcogenide (TMD), where the confined dynamical interaction between excitons and phonons is unexplored. The coherent oscillatory motion of the out-of-plane $A'_{1}$ phonons, triggered by the ultrashort laser pulses, dynamically modulates the excitonic resonances on a timescale of few tens fs. We observe an enhancement by…
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…
Effect of aerobic exercise and low carbohydrate diet on pre-diabetic non-alcoholic fatty liver disease in postmenopausal women and middle aged men: s…
2014
Background. Pre-diabetes and non-alcoholic fatty liver disease (NAFLD) are associated with an unhealthy lifestyle and pose extremely high costs to the healthcare system. In this study, we aim to explore whether individualized aerobic exercise (AEx) and low carbohydrate diet (LCh) intervention affect hepatic fat content (HFC) in pre-diabetes via modification of gut microbiota composition and other post-interventional effects. Methods/design. A 6-month randomized intervention with 6-month follow-up is conducted from January 2013 to December 2015. The target sample size for intervention is 200 postmenopausal women and middle-aged men aged 50–65 year-old with pre-diabetes and NAFLD. The qualifi…
Eating behavior dimensions and 9-year weight loss maintenance : a sub-study of the Finnish Diabetes prevention study
2023
Abstract Background Behavioral processes through which lifestyle interventions influence risk factors for type 2 diabetes (T2DM), e.g., body weight, are not well-understood. We examined whether changes in psychological dimensions of eating behavior during the first year of lifestyle intervention would mediate the effects of intervention on body weight during a 9-year period. Methods Middle-aged participants (38 men, 60 women) with overweight and impaired glucose tolerance (IGT) were randomized to an intensive, individualized lifestyle intervention group (n = 51) or a control group (n = 47). At baseline and annually thereafter until nine years body weight was measured and the Three Factor Ea…
The south coast of Palermo. Planning the resilient city
2017
Il contributo individua i temi progettuali per la definizione di temi di progetto sul territorio della cosiddetta "costa sud" della città di Palermo. Il contributo descrive i temi di sviluppo, analizza le risorse presenti e definisce alcuni elementi progettuali che verranno sviluppati sia all'interno della ricerca presentata nel volume, sia nelle politiche di trasformazione urbana del Comune di Palermo. The paper identifies the design themes for project in the so-called "south coast" of the city of Palermo. The contribution describes the development themes, analyzes the resources present and defines some design elements that will be developed both within the research presented in the volume…
Antioxidant Therapies and Oxidative Stress in Friedreich´s Ataxia: The Right Path or Just a Diversion?
2020
Friedreich's ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract such boost of free radicals and to enhance the production of antioxidant defenses. In this work, we present and critically review those 'antioxidant' drugs that went beyond the disease's models and were approved for its application in clinical trials. The evaluation of these trials highlights some …
Alteraciones vasculares inducidas por un modelo de síndrome metabólico en conejo.
2019
El síndrome metabólico (SMet) es una enfermedad multifactorial que cursa con al menos tres de los siguientes factores: obesidad central, disglucemia, aumento de la presión sanguínea, triglicéridos aumentados o lipoproteínas de alta densidad disminuidas en plasma. El SMet afecta a los vasos sanguíneos alterando su reactividad, debido a un desequilibrio entre las sustancias vasodilatadoras y vasoconstrictoras a favor de la vasoconstricción. En esta tesis estudiamos los efectos del SMet en arterias de conejo (aorta abdominal, carótida y renal) analizando la reactividad vascular a agonistas contráctiles, como el cloruro potásico (KCl), la norepinefrina (NE) y la endotelina-1 (ET-1), y relajante…
Metacognizione e comprensione della lettura: quale rapporto?
2019
Una lettura competente implica l’utilizzo di specifiche strategie meta-cognitive e molteplici livelli di elaborazione delle informazioni che, se impiegate in modo consapevole, migliorano la comprensione. In que-sto lavoro si presenta un approfondimento sulla relazione tra metaco-gnizione, thinking aloud e comprensione della lettura, che si colloca all’interno alla ricerca nazionale RC-RT descritta in questo stesso vo-lume e volta a verificare l’efficacia del Reciprocal Teaching nel contesto italiano. Dopo aver presentato alcune ricerche svolte su allievi di età diverse finalizzati ad evidenziare il rapporto tra la comprensione della lettura e le abilità di secondo livello, raggruppate sotto…