Search results for " meta"

The Circularity of MSW in Urban Landscapes: An Evaluation Method for a Sustainable System Implementation

2022

The debate on the sustainable perspective of a circular economy and MSW (Municipal Solid Waste) management is no longer focused on the resolution of an emergency and on the pure technicality of creating efficient services. New light has been shed on the operational phase, as often unresolvable technical-environmental issues during service management lead to a state of decay, affecting urban vulnerability and users’ involvement. The research aims to develop an auxiliary tool for public administrations in planning a zero-waste future whilst enhancing the urban landscape. This study considers the perspective of virtuous management of the resource flow cycle along with evaluating implementable …

Application of algae in active biomonitoring of the selected holding reservoirs in swietokrzyskie province

2016

During the years 2014-2015, biomonitoring studies were carried out at three holding reservoirs located in Swietokrzyskie Province (central Poland): Kielce artificial lake, Chancza reservoir and Sielpia reservoir. In sea water algae Palmaria palmata (Linnaeus) Weber & Mohr, exposed in the analysed waters, the increases of concentrations were determined by the atomic absorption spectrometry method (AAS), of the following: Mn, Fe, Cu, Zn, Cd and Pb. Conductivity and pH were also determined in the reservoirs waters. The differences between the increases of heavy metal concentrations in the samples of algae found along the coastline were indicated; they result from different distances from the p…

Occurrence of some heavy metals in waters and bottom sediments in two small dam reservoirs

2008

Regulation of immune response in post-operative endophthalmitis

2011

Regulation of immune response in post-operative endophthalmitis. annual meeting of the association-for-research-in-vision-and-ophthalmology (ARVO)

HMG-CoA reductase inhibitors (statins) as anticancer drugs (Review)

2005

Apart from their lipid lowering activity, HMG-CoA reductase inhibitors (statins) impair numerous cellular functions associated with metastasis, e.g. gene expression, angiogenesis, cell adhesion, cell motility and invasiveness. Furthermore, statins have impact on apoptotic cell death and modulate cellular susceptibility to cell killing by anticancer drugs and ionizing radiation. Part of the effects provoked by statins are due to the inhibition of the prenylation of low molecular weight GTPases, in particular Ras and Rho, which play key roles in signaling evoked by stimulation of cell surface receptors. C-terminal lipid modification of Ras/Rho GTPases is essential for their correct intracellu…

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.

2003

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that mediate phospholipase D (PLD) activation in brain, but the mechanism underlying this response remains unclear. Here we used primary cultures of astrocytes as a cell model to explore the mechanism that links mGluRs to PLD. Glutamate activated both phospholipase C (PLC) and PLD with equal potency and this effect was mimicked by L-cysteinesulfinic acid, a putative neurotransmitter previously shown to activate mGluRs coupled to PLD, but not PLC, in adult brain. PLD activation by glutamate was dependent on Ca(2+) mobilization and fully blocked by both protein kinase C (PKC) inhibitors and PKC down-regulation, suggesti…

A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo

2015

AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…

Christian metal online : the discursive construction of identity and culture

2015

Epistemic, interpersonal, and moral stances in the construction of us and them in Christian metal lyrics

2011

Religious groupings and subcultures both tend to have well-articulated interests, aims, and values that unite certain people but also alienate those who do not share their interests. The case is then made for the construction of difference between 'us' and 'them'. This paper examines the construction of such a group boundary in the previously little studied context of the Christian metal (CM) music subculture. The focus of analysis is on the kinds of stances that are taken and attributed to 'us' and 'them' in the English lyrics of Finnish CM groups. The particular types of stance are related to questions of epistemology, interpersonality, and morality. The paper shows that the borderlines b…

Specialized Movement on the Rowing Ergometer and Post-workout Changes in Selected Peripheral Blood Parameters – a Case Report.

2018

Rowing is a sport discipline, which requires extreme physical strength and endurance and appropriate aerobic and anaerobic capacity as well. However, when the workout intensity and load is very high, exercise is associated with temporary changes in cellular metabolism and the immune system. The study included one male rower aged 28 years – the highly-skilled and experienced athlete. We determined basic cardiorespiratory fitness measures, complete blood count, and 24 clinical chemistry parameters including relevant biochemical and haematological parameters and matrix metaloproteinases activities. Maximal exercise on the rowing ergometer induced 2-fold increase in absolute counts of all leuko…