Search results for " meta"
showing 10 items of 9626 documents
”On ollut etuoikeus opiskella ruotsia”: yliopisto-opiskelijat pohtivat ruotsin kieltä ja sen opiskelua
2017
Artikkelissa esitellään narratiivista tutkimusta, jossa tarkastellaan ruotsia toisena kotimaisena kielenä opiskelevien suomenkielisten ja kaksikielisten yliopisto-opiskelijoiden pohdintoja ruotsin kielestä ja sen opiskelusta. Tuloksista ilmenee, että opiskelijoilla on yleensä vahva tunneside ruotsin kieleen ja sen opiskeluun. Ruotsin kieli koetaan rakkaana ja arvokkaana, ja sitä opiskellaan päättäväisesti, vaikka mediassa ja lähipiirissäkin esiintyvät negatiiviset asenteet ruotsin opiskelua kohtaan koetaan haasteellisina. nonPeerReviewed
Gut microbiome and atrial fibrillation - results from a large population-based study
2023
Background Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown. Methods We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case–control cohort of 138 individuals in Hamburg, Germany. Findings Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 5…
Safety of Tyrosine Kinase Inhibitors in Patients With Differentiated Thyroid Cancer: Real-World Use of Lenvatinib and Sorafenib in Korea
2019
Background: Thyroid cancer has become the most common cancer in Korea. Generally, thyroid cancer patients have a good prognosis; however, 15–20% of patients experience recurrence or distant metastasis or are refractory to standard treatment. We assessed the safety of sorafenib and lenvatinib in patients with advanced or metastatic radioactive iodine-refractory differentiated thyroid cancers (DTC) consecutively treated at a tertiary center in South Korea.Methods: We retrospectively reviewed the charts of all consecutive patients with DTC treated during ≥6 months with lenvatinib (February 2016–April 2018) and sorafenib (January 2014–April 2018) at Gangnam Severance Hospital. Patients were tre…
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Safety and potential interaction of immunosuppressive drugs for the treatment of inflammatory bowel disease in elderly patients
2021
Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are chronic diseases associated with increased morbidity and reduced quality of life. Age may represent a risk factor for adverse events, due to the multimorbidity and polypharmacy, common in elderly patients. Elderly are often not included in clinical trials evaluating efficacy and safety of study drugs for the treatment of inflammatory bowel diseases. Several drugs, such as aminosalicylates, systemic corticosteroids, immunosuppressant drugs, biological drugs and Janus Kinase inhibitors, are available for the management of inflammatory bowel diseases. With the increasing spectrum of therapeutic options, it is th…
Systematic review and exploratory meta-analysis of the efficacy, safety, and biological effects of psychostimulants and atomoxetine in patients with …
2019
ObjectiveOur aim was to summarize the efficacy and safety of atomoxetine, amphetamines, and methylphenidate in schizophrenia.MethodsWe undertook a systematic review, searching PubMed/Scopus/Clinicaltrials.gov for double-blind, randomized, placebo-controlled studies of psychostimulants or atomoxetine in schizophrenia published up to 1 January 2017. A meta-analysis of outcomes reported in two or more studies is presented.ResultsWe included 22 studies investigating therapeutic effects of stimulants (k=14) or measuring symptomatic worsening/relapse prediction after stimulant challenge (k=6). Six studies of these two groups plus one additional study investigated biological effects of psychostimu…
Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia
2017
ObjectiveOur aim was to perform an updated systematic review and meta-analysis on the efficacy and safety of adjunctive minocycline as a treatment of schizophrenia.MethodsWe conducted a PubMed/Scopus database search from inception to 3 February 2016 for randomized, placebo-controlled trials (RCTs), open non-randomized studies, and case reports/series evaluating minocycline in patients with schizophrenia. Random-effects meta-analysis of positive, negative, depressive, and cognitive symptom rating scales, discontinuation and adverse effects rates calculating standardized mean difference (SMD), and risk ratios±95% confidence intervals (CI95%) were calculated.ResultsSix RCTs were eligible (mino…
Metal salen complexes as ethylene polymerization catalysts - effect of catalytic system composition on its activity and properties of polymerization …
2008
Zsyntetyzowano i zastosowano [po aktywacji metyloaluminoksanem (MAO) lub Et2AlCl] w charakterze katalizatorów niskociśnieniowej polimeryzacji etylenu serię salenowych kompleksów metali przejściowych różniących się rodzajem atomu centralnego (M=Ti, Zr lub V) i budową chemiczną ligandu (schemat A). Stwierdzono, że salenowe kompleksy cyrkonu są aktywne w polimeryzacji jedynie wówczas, gdy aktywator stanowi MAO, natomiast kompleksy tytanu i wanadu są aktywniejsze w przypadku gdy kokatalizatorem jest typowy związek glinoorganiczny - dietylochloroglin. Aktywność kompleksów w układzie z Et2AlCl zmienia się w szeregu V>Ti>>Zr?0, podczas gdy w odniesieniu do kompleksów aktywowanych MAO maleje ona w …
Metaforer i svenska och finska innebandyartiklar på internet
2006
Analisi sperimentale degli ioni metallici presenti nella saliva di soggetti portatori di apparecchi ortodontici mobili
2016
Fino a pochi decenni addietro, il fenomeno dell’esposizione a basse concentrazioni di agenti tossici era considerato soltanto un problema di igiene ambientale. In realtà vari studi1-5 hanno approfondito, grazie al monitoraggio biologico, il concetto di “esposizione a basse dosi” di agenti tossici o elementi in tracce: pertanto nei suddetti studi, gli autori concludono che le “basse dosi” corrispondono a una esposizione tale che le concentrazioni della sostanza in esame si mantengono, nei fluidi biologici (per la popolazione esposta), al di sopra dei valori massimi di riferimento (stabiliti per la popolazione generale) e al di sotto dei valori-limite biologici.