Search results for " metabolites"
showing 10 items of 67 documents
The ethnobotany, phytochemistry and biological properties of genus Ferulago – A review
2020
Abstract Ethnopharmacological relevance The genus Ferulago, belonging to the Apiaceae family, is found mainly in the Mediterranean area, Southwest and Middle Asia, the Caucasus and North Africa. Since ancient times, species of this genus have been largely employed in traditional medicine for their biological properties such as antimicrobial, anti-inflammatory, antispasmodic, insecticidal, and anti-malaria, cholinesterase inhibition effects, etc. Aims The scope of this paper is to present a comprehensive respect review of this interesting genus including traditional uses, chemical composition of volatile and non-volatile metabolites, and in vitro and in vivo biological properties either util…
Effects of air pollution on production of essential oil in Feijoa Sellowiana Berg. grown in the "Italian triangle of death"
2010
The composition of the essential oils of fruits from Feijoa sellowiana grown in the district of Acerra is compared with those collected from unpolluted sites. Essential oils from the fruits of F. sellowiana were analysed by GC/MS. Sixty compounds, representing 96.6% and 97.8% (unpolluted site and Acerra site, respectively) of the oils, were identified. The major constituents were β-caryophyllene (12.4% and 16.8%), ledene (9.6% and 11.1%), α-humulene (6.3% and 8.2%), β-elemene (4.9% and 5.3%) and δ-cadinene (4.7% and 5.2%) in the control site and Acerra site, respectively. The antioxidant components were increased in response to polluted condition. The acetonic extracts of F. sellowiana from…
Metabolites from the aerial parts of the Sicilian population of Artemisia alba Turra
2013
Phytochemical investigation of the CH2Cl2 extract of the aerial parts of Artemisia alba Turra afforded one new irregular sesquiterpenoid, artemiric acid, and five known metabolites: hydroxydavanone, the coumarins isofraxidin and scopoletin, (6S*,7S*,10R*)-6,10-dimethyl-7,10-epoxyocta-11-enoic acid and artalbic acid. From the MeOH extract three flavonoids were identified: chrysoeriol, quercetin and isorhamnetin. The possible biogenetic pathways of artemiric and artalbic acids are discussed.
Ethnobotany, Phytochemistry, Biological, and Nutritional Properties of Genus Crepis—A Review
2022
The genus Crepis L., included within the Asteraceae family, has a very wide distribution, expanding throughout the northern hemisphere, including Europe, northern Africa, and temperate Asia. This genus has a fundamental value from biodynamic and ecological perspectives, with the different species often being chosen for soil conservation, for environmental sustainability, and for their attraction towards pollinating species. Furthermore, various species of Crepis have been used in the popular medicine of several countries as medicinal herbs and food since ancient times. In most cases, the species is consumed either in the form of a decoction, or as a salad, and is used for its cardiovascular…
Bioactive compounds from brown algae inhabiting the north-western Mediterranean Sea
2021
Marine algae produce a great amount of secondary metabolites (e.g. terpenoids, fatty acids, steroids, polysaccharides and polyphenols) to face environmental stressors they are exposed to, but also to defend themselves from biological pressures such as competitors, pathogens, grazers and epiphytes. Over the last decade, secondary metabolites isolated from brown algae and phenolic compounds, in particular, are receiving increasing attention due to their putative ecological roles, and several biological properties. Brown fucoid algae of the genus Cystoseira sensu latu (Sargassaceae) and Dictyotaceae produce a wide variety of secondary metabolites which have been investigated mainly for their d…
Total phenolic content in brown algae from the Sicilian coast
2019
Phlorotannins are polyphenolic secondary metabolites found in almost all brown algae that function as defense against grazers, pathogens and epiphytes but are also involved in photoprotection mechanisms. These com- pounds, produced in the Golgi apparatus, are accumulated in cytoplasm, within vesicules called physodes, or bound to the cell wall. The concentration of phlorotannins differs within and between species, shows geograph- ical variations but may be also affected by abiotic or biotic factors. We present here an overview of the studies carried out on total phenolic content in brown algae collected along the north-western coast of Sicily. The aims of these studies were in particular a)…
Charged Tags for the Identification of Oxidative Drug Metabolites Based on Electrochemistry and Mass Spectrometry
2020
Abstract Most of the active pharmaceutical ingredients like Metoprolol are oxidatively metabolized by liver enzymes, such as Cytochrome P450 monooxygenases into oxygenates and therefore hydrophilic products. It is of utmost importance to identify the metabolites and to gain knowledge on their toxic impacts. By using electrochemistry, it is possible to mimic enzymatic transformations and to identify metabolic hot spots. By introducing charged‐tags into the intermediate, it is possible to detect and isolate metabolic products. The identification and synthesis of initially oxidized metabolites are important to understand possible toxic activities. The gained knowledge about the metabolism will…
Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line
2008
International audience; Human can be exposed to bis(hydroxyphenyl)methane (bisphenol F or BPF) and its derivatives as environment and food's contaminants. This study was investigated to identify and to compare toxic potency of BPF, BFDGE, and two of BPF metabolites using in vitro methods. BPF did not induce any genic mutation in bacteria when the Ames test was performed according to the OECD guideline. In contrast, using Human cell lines and Comet assay, we demonstrated that BPF and Bisphenol F Diglycidyl Ether (BFDGE) were effective on HepG2 cell DNA fragmentation at non-cytotoxic concentrations. DHB was also positive but at higher concentrations, near its limit of solubility. Neither BPF,…
The presence of conifer resin decreases the use of the immune system in wood ants.
2008
5 pages; International audience; 1. Wood ants ( Formica paralugubris ) incorporate large amounts of solidified conifer resin into their nest, which reduces the density of many bacteria and fungi and protects the ants against some detrimental micro-organisms. By inducing an environment unfavourable to pathogens, the presence of resin may allow workers to reduce the use of their immune system. 2. The present study tested the hypothesis that the presence of resin decreases the immune activity of wood ants. Specifically, three components of the humoral immune defences of workers kept in resin-rich and resin-free experimental nests (antibacterial, lytic, and prophenoloxidase activities) were com…
Field-Grown and In Vitro Propagated Round-Leaved Sundew (Drosera rotundifolia L.) Show Differences in Metabolic Profiles and Biological Activities
2021
Drosera rotundifolia L. is a carnivorous plant used in traditional medicine for its therapeutic properties. Because of its small size, its collection in nature is laborious and different cultivation methods have been studied to ensure availability. However, only a few studies exist where the lab-grown sundew tissue and field-grown sundew would have been compared in their functionality or metabolic profiles. In this study, the antioxidant and antiviral activities of lab-grown and field-grown sundew extracts and their metabolic profiles are examined. The effect of drying methods on the chromatographic profile of the extracts is also shown. Antioxidant activity was significantly higher (5–6 ti…