Search results for " modelling"
showing 10 items of 1055 documents
Cancer growth dynamics: stochastic models and noise induced effects
2009
In the framework of the Michaelis‐Menten (MM) reaction kinetics, we analyze the cancer growth dynamics in the presence of the immune response. We found the coexistence of noise enhanced stability (NES) and resonant activation (RA) phenomena which act in an opposite way with respect to the extinction of the tumor. The role of the stochastic resonance (SR) in the case of weak cancer therapy has been analyzed. The evolutionary dynamics of a system of cancerous cells in a model of chronic myeloid leukemia (CML) is investigated by a Monte Carlo approach. We analyzed the effects of a targeted therapy on the evolutionary dynamics of normal, first‐mutant and cancerous cell populations. We show how …
Design, modelling, and analysis of a large floating dock for spar floating wind turbine installation
2020
Installation of floating wind turbines at the offshore site is a challenging task. A significant part of the time efficiency and costs are related to the installation methods which are sensitive to weather conditions. This study investigates a large floating dock concept, which can be used to shield a floating wind turbine during installation of tower, nacelle, and rotor onto a spar foundation. In this paper, the concept is described in detail, and a design optimisation is carried out using simple design constraints. Hydrodynamic analysis and dynamic response analysis of the coupled system of the optimum dock and spar are conducted. Two spars of different sizes are considered, and the motio…
A direct comparison of 2D versus 3D diffusion analysis at nanowire electrodes: A finite element analysis and experimental study
2022
In electroanalysis, the benefits accrued by miniaturisation are a key driver in sensor development. Finite element simulations of electrochemical processes occurring at ultramicro- and nano-electrodes are used to provide key insight into experimental design in relation to diffusion profiles and expected currents. The most commonly used method, the diffusion domain approach (DDA) offers a means of reducing a three dimensional design to two dimensions to ease computational demands. However, the DDA approach can be limited when using basic assumptions which can be incorrect, for example that all electrodes in an array are equivalent. Consequently, to get a more realistic view of molecular diff…
Economic analysis of the scale-up and implantation of a hollow fibre membrane contactor plant for nitrogen recovery in a full-scale wastewater treatm…
2021
[EN] Nitrogen recovery technologies such as the hollow fibre membrane contactor are now being developed. However, an economic analysis is needed prior to their full-scale application in wastewater treatment plants. The aim of this study was to analyse the economic and environmental aspects of scaling-up this method. To achieve it, a full-scale 40,000 m3·day¿1-wastewater treatment plant influent flow rate was simulated jointly with a membrane contactor plant to evaluate the minimum costs of optimum operating conditions of membrane contactors (pH, feed flow rate and membrane surface). The optimum conditions for treating 600 m3·day¿1 of reject water was found to be 10 pH, 0.08 m3·s¿1 feed flow…
Dissipative connections of rc frames with prefabricated steel-trussed-concrete beams
2020
In the last thirty years, Hybrid Steel-Trussed Concrete Beams (HSTCBs) have been widely used in civil and industrial constructions and, therefore, their mechanical performance must be evaluated with the aim of guaranteeing adequate dissipation of the seismic energy particularly in the beam-to-column joints. However, one of the most frequent peculiarities of HSTCBs is that of using their own steel joist to cover large spans with reduced depth and, in the case of traditional beam-to-column connections, this requires large amount of steel reinforcement inside the panel zone, often made with large diameter rebars. These characteristics make both the panel zone and the beam end potentially vulne…
Non-local multiscale approach for the impact of go or grow hypothesis on tumour-viruses interactions
2021
International audience; We propose and study computationally a novel non-local multiscale moving boundary mathematical model for tumour and oncolytic virus (OV) interactions when we consider the go or grow hypothesis for cancer dynamics. This spatio-temporal model focuses on two cancer cell phenotypes that can be infected with the OV or remain uninfected, and which can either move in response to the extracellular-matrix (ECM) density or proliferate. The interactions between cancer cells, those among cancer cells and ECM, and those among cells and OV occur at the macroscale. At the micro-scale, we focus on the interactions between cells and matrix degrading enzymes (MDEs) that impact the mov…
Gain-scheduled H-infinity observer design for nonlinear stochastic systems with time-delay and actuator saturation
2012
In this paper, we propose a method for designing continuous gain-scheduled robust H ∞ observer on a class of extended stochastic nonlinear systems subject to time delay and actuator saturation. Initially, gradient linearization procedure is applied to describe such extended nonlinear systems into several model-based linear systems. Next, a robust linear H ∞ observer is designed to such linear stochastic models. Subsequently, a convex hull set is investigated and sufficient condition is derived in terms of feedback observer to determine whether a given initial condition belongs to an ellipsoid invariant set. Finally, continuous gain-scheduled approach is employed to design continuous nonline…
A taxonomy for wavelet neural networks applied to nonlinear modelling
2008
This article presents a novel classification of wavelet neural networks based on the orthogonality/non-orthogonality of neurons and the type of nonlinearity employed. On the basis of this classification different network types are studied and their characteristics illustrated by means of simple one-dimensional nonlinear examples. For multidimensional problems, which are affected by the curse of dimensionality, the idea of spherical wavelet functions is considered. The behaviour of these networks is also studied for modelling of a low-dimension map.
The kinetics of defect aggregation: A novel lattice formalism
1995
We introduce a stochastic model for the A + B → O reaction on a discrete lattice. The system may include mono- and bimolecular steps (i. e. reaction and diffusion steps). The resulting infinite chain of equations is truncated at a certain level via a modified Kirkwood approximation.
Fuzzy modelling of HEART methodology: application in safety analyses of accidental exposure in irradiation plants
2009
The present paper refers to the obtained results by using Fuzzy Fault Tree analyses of accidental scenarios which entail the potential exposure of operators working in irradiation industrial plants. For these analyses the HEART methodology, a first generation of the Human Reliability Analysis method, has been employed to evaluate the probability of human erroneous actions. This technique has been modified by us on the basis of fuzzy set concept to more directly take into account the uncertainties of the so called error-promoting factors, on which the method is grounded. The results allow also to provide some recommendations on procedures and safety equipments to reduce the radiological expo…