Search results for " modifica"

The EPPS16 nuclear PDFs

2017

We report on EPPS16 - the first analysis of NLO nuclear PDFs where LHC p-Pb data (Z, W, dijets) have been directly used as a constraint. In comparison to our previous fit EPS09, also data from neutrino-nucleus deeply-inelastic scattering and pion-nucleus Drell-Yan process are now included. Much of the theory framework has also been updated from EPS09, including a consistent treatment of heavy quarks in deeply-inelastic scattering. However, the most notable change is that we no longer assume flavour-blind nuclear modifications for valence and sea quarks. This significantly reduces the theoretical bias. All the analysed data are well reproduced and the analysis thereby supports the validity o…

Microfibrillar polymeric ocular inserts for triamcinolone acetonide delivery.

2019

Abstract Despite eye drops generally represent the most convenient, simple and patient-friendly formulations to treat ocular diseases, they suffer from poor retention on the ocular surface and low drug bioavailability leading to the necessity of prolonged and continuous treatment over time. Therefore, ocular insert could represent an innovative way to benefit from ocular topical administration while minimizing all the relevant limitation related to this route of administration. Polymeric non-erodible mucoadhesive ocular inserts should be comfortable and should rapidly adhere on the ocular surface, remain in situ for prolonged period, assure a reproducible and controlled drug release as well…

Pectin as Drug-Release Vehicle

2020

Pectin as a natural biopolymer is extensively used for pharmaceutical and biomedical applications, essentially due to its gelling properties that could be influenced by pectin sources and extraction methods. This chapter focuses on an overview of pectin drug delivery systems classified by their administration routes. Oral drug delivery systems have been mainly developed, as pectin could be used in tablets as binder or matrix excipients and in microparticles/beads obtained by ionotropic gelation. The main objective is to target the colon, as pectin is resistant in acidic pH and sensitive to pectinolytic enzymes in the colon. To obtain suitable properties, pectin could be used in its native s…

Asphalt mixtures improved with plastic additives: mix design and case study in an airport

La crescente domanda di prestazioni e le esigenze di salvaguardia dell’ecosistema spingono a sviluppare nuove tecnologie di lavorazione, a sperimentare l’impiego di nuovi materiali, a migliorare i metodi di progetto delle miscele. Il criterio seguito è quello di un impiego più razionale delle risorse e dell’utilizzo di tecniche a basso impatto ambientale. Per ragioni tecniche ed economiche stiamo assistendo al fenomeno di espansione nel mercato degli additivi, impiegati nella produzione di miscele bituminose per migliorarne le prestazioni e ridurre i costi. In generale, però riuscire a soddisfare tutti gli obiettivi con un unico prodotto è difficile, perché l’alta qualità richiede costi più…

Long-term analysis (1863–2002) of environmental change in the Capo Feto area (Mediterranean sea)

2004

The area of Capo Feto represents one of the few remaining salt-marshy zones in Sicily. It lies within a site of importance for the Community (defined as a “sito di importanza comunitaria” (SIC)), which also includes Margi Spanò and Margi Milo. The Capo Feto and Margi Spanò marshlands have also been identified by the Ministry for the Environment as an area deserving special protection (“zona a protezione speciale” (ZPS)). Moreover, in 1999, 150 ha of the Capo Feto area were included in a project for environmental rehabilitation as part of the European Union “Life-Nature 2000” programme (Comitato Tecnico-Scientifico Area di Capo Feto, 1997). Prior to this, the area had become somewhat degrade…

Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin α-H2A Histone Gene

2007

The tandemly repeated sea urchin alpha-histone genes are developmentally regulated. These genes are transcribed up to the early blastula stage and permanently silenced as the embryos approach gastrulation. As previously described, expression of the alpha-H2A gene depends on the binding of the MBF-1 activator to the 5' enhancer, while down-regulation relies on the functional interaction between the 3' sns 5 insulator and the GA repeats located upstream of the enhancer. As persistent MBF-1 binding and enhancer activity are detected in gastrula embryos, we have studied the molecular mechanisms that prevent the bound MBF-1 from trans-activating the H2A promoter at this stage of development. Her…

Functional interaction of estrogen receptor α and caveolin isoforms in neuronal SK-N-MC cells

2003

Estrogen receptors (ERs) are expressed in neuronal cells and exhibit a wide variety of activities in the central nervous system. The actions of ERs are regulated in a hormone-dependent manner as well as by a number of co-activators and -repressors. A recently identified co-activator of ERalpha is caveolin-1 which has been shown to mediate the ligand-independent activation of this steroid receptor. In the present study we have demonstrated that neuronal SK-N-MC cells lacking functional ERalpha show high levels of caveolin-1/-2 specific transcripts and proteins. Ectopic expression of ERalpha in SK-N-MC cells leads to the transcriptional suppression of caveolin-1 and -2 genes. This silencing e…

Finite Element Simulation of Multilayer Metal Cylinder Head Gaskets

2006

ABAQUS gasket elements are an efficient and flexible tool to study gasket applications. Nevertheless the usage of the ABAQUS gasket elements is not limited to gasket analysis, but it provides an effective improvement in structural analysis. The results point out that both the predicted contact pressure and the predicted stress distribution depend on the mesh topology. Several combinations of mesh dimension and topology are investigated. The purpose is the definition of a calculation methodology and the demonstration of the application potentiality. Complex models analysis highlights that the set methodology constitutes a very effective tool for the design and optimization of gasket, cylinde…

Functionalization of ultrasound enhanced sewage sludge-derived biochar: Physicochemical improvement and its effects on soil enzyme activities and hea…

2020

Abstract Poor physicochemical characteristics and high heavy metals content are main limitations of applying sludge-based biochars in remediation studies. The present study attempts to combine two practical approaches of ultrasound pre-treatment with low-time and low-frequency and chemical functionalization using citric acid. The aims of this study are enhancement physicochemical characteristics and environmental applicability of sludge-derived biochar. The characteristics of obtained ultrasound-treated functionalized biochar (UFB), sludge-derived biochar (SDB) and sewage sludge (SS) were evaluated. Then, the effects of these additives on soil heavy metals availability, soil enzyme activiti…

Novel modified poly vinyl chloride blend membranes for removal of heavy metals from mixed ion feed sample

2017

Herein, an attempt has been made to prepare a novel membrane with good efficiency for removal of heavy metal ions namely lead (Pb), cadmium (Cd) and chromium (Cr). 4-amino benzoic acid (ABA) was covalently grafted onto the poly vinyl chloride (PVC) backbone by CN bond to enhance the hydrophilicity. 1H NMR and ATR-IR spectroscopy analysis confirmed the chemical modification of PVC. Further the modified polymer was blended in different compositions with polysulfone (PSf) for optimization. Morphological changes that occurred in blend membranes, due to the incorporation of modified PVC was studied by AFM and SEM techniques. The effect on hydrophilicity and performance of blends owing to incorpo…