Search results for " modifica"
showing 10 items of 817 documents
Dictamen profesional sobre la fusión y escisión como extrategias alternativas en un grupo de sociedades
2021
This work is a professional, legal opinion which sets out two alternative strategies (merger by absorption and partial demerger) in order to bring together the different areas of activity of the various companies in a group of companies. The aim is to provide solutions to the questions raised by customers and, therefore, to set out clearly and simply the procedure to be followed in each of the strategies, weighing up the advantages and disadvantages from each of them
The Use of Question Modification Strategies to Differentiate Instruction in Eritrean Mathematics and Science Classrooms
2023
This qualitative study aimed at examining the question modification strategies Eritrean elementary and middle school teachers used to differentiate their instruction and meet the diversity in the classroom as well as the functions these strategies served in classroom interactions. The research data consisted of videotaped recordings (N = 11 videotaped lessons) of classroom interactions in eight mathematics and science classrooms, which were analysed through interaction analysis. The findings showed that Eritrean teachers utilised the following five question modification strategies either independently or in combination: repetition; rephrasing; clarification; decomposition; and code-switchin…
Data from: Climate determinants of breeding and wintering ranges of lesser kestrels in Italy and predicted impacts of climate change
2017
Climate warming would theoretically create conditions for the breeding range expansion of pseudo-steppe Mediterranean and long-distance migrant species and provide the possibility for these to overwinter in the same breeding areas. However, contemporary changes in rainfall regimes might have negative effects on the climate suitability and in turn, shrink species potential range. The lesser kestrel Falco naumanni is highly sensitive to rainfall oscillations and has recently extended its Italian breeding range towards northern latitudes and increasing its wintering records. We modelled the effects of temperature and rainfall on current and future climate suitability for lesser kestrels in bot…
Mesoporous Silica-Based Materials with Bactericidal Properties
2019
[EN] Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial …
Diabetes: Psychosocial Aspects
2015
This article is a revision of the previous edition article by K. Chamberlain, volume 6, pp. 3628–3631, © 2001, Elsevier Ltd.
Long-term effectiveness of agalsidase alfa enzyme replacement in Fabry disease: A Fabry Outcome Survey analysis
2015
Outcomes from 5 years of treatment with agalsidase alfa enzyme replacement therapy (ERT) for Fabry disease in patients enrolled in the Fabry Outcome Survey (FOS) were compared with published findings for untreated patients with Fabry disease. Data were extracted from FOS, a Shire-sponsored database, for comparison with data from three published studies. Outcomes evaluated were the annualized rate of change in estimated glomerular filtration rate (eGFR) and left ventricular mass indexed to height (LVMI) as well as time to and ages at a composite morbidity endpoint and at death. FOS data were extracted for 740 treated patients who were followed for a median of ~ 5 years. Compared with no trea…
Initiation and progression of atherosclerosis – enzymatic or oxidative modification of low-density lipoprotein?
2006
AbstractAtherosclerosis is widely regarded as a chronic inflammatory disease that develops as a consequence of entrapment of low-density lipoprotein (LDL) in the arterial intima. Native LDL lacks inflammatory properties, so the lipoprotein must undergo biochemical alterations to become atherogenic. Among several other candidates, two different concepts of lipoprotein modification are propagated, the widespread oxidation hypothesis and the less common E-LDL hypothesis, which proposes that modification of LDL occurs through the action of ubiquitous hydrolytic enzymes (enzymatically modified LDL or E-LDL) rather than oxidation. By clearly distinguishing between the initiation and progression o…
Substance P inactivation by transglutaminase in vitro.
1992
Gamma(glutamyl5)spermine derivative of substance P (Spm-SP) was synthesized in vitro in the presence of purified guinea pig liver transglutaminase and Ca2+. The spermine adduct of the neuropeptide was purified by HPLC on a reversed-phase column and characterized by fast atom bombardment mass spectrometry. The biological activities of Spm-SP were tested by assaying, in comparison with substance P, its ability to induce both the contractions of smooth muscle in vitro and the edema formation in vivo. Spm-SP was shown not to elicit contractile responses in the isolated rat stomach strip and duodenum and not to antagonize the spasmogenic effect evoked by the native neuropeptide. Furthermore, Spm…
Structural and functional salivary disorders in type 2 diabetic patients
2006
La diabetes mellitus tipo 2 es el desorden metabólico más frecuente, siendo además causante de una importante morbi-mortalidad. En estos pacientes se han descrito alteraciones estructurales de la parotida (sialosis) que podrían comportar modificaciones en la composición salivar, así como un incremento de patología dental y periodontal. Objetivos: establecer las alteraciones bioquímicas de la saliva y su posible correlación con los hallazgos morfológicos. Diseño del estudio: se realizo un estudio clínico de 33 pacientes, 17 de ellos con diabetes tipo 2. Se recogieron muestras de saliva para análisis bioquímico y suero para control metabólico. Resultados: en la saliva de los pacientes diabéti…
Surface modification of gold nanoparticles and nanoclusters
2016
Gold nanoparticles are used in many beneficial technological applications in biochemistry, medicine and electronics. Among them, monolayer protected gold nanoclusters (MPCs) have received a significant attention in the scientific community due to their well-defined atomic structure, which is important for fundamental studies of nanoparticles properties and their functionalization. These particles, with a precise number of atoms, exhibit size-dependent optical, chemical and electronic properties. The thesis focuses on the structure, preparation, characterization, and properties of MPCs. For multifunctional applications, gold nanoparticles are an ideal class of compounds for surface functiona…