Search results for " modulation"

Novel evidences for a role of dopamine as modulator of intestinal motility: a study on mouse distal colon

2014

Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. It has been classically considered that the pathological hallmarks of PD affect primarily the substantia nigra. Nevertheless, it has become increasingly evident that PD is a multicentric neurodegenerative process that affects several neuronal structures outside the substantia nigra, among which is the enteric nervous system (ENS). Pathological alterations within the ENS could be involved in the gastrointestinal (GI) dysfunction frequently encountered by PD patients. Dopamine (DA) seems to be a major candidate for the impairment of GI function in PD since its levels were found to be decrea…

Wharton’s jelly mesenchymal stem cells differentiation into hepatocyte-like cells: functional characterization and expression of immunomodulatory mol…

2015

Mesenchymal stem cells derived from Wharton’s jelly (WJ-MSCs) recently emerged as promising tools for cellular therapy due to their ability to differentiate into diverse cell types and their immunomodulatory features. Little is known on the expression of immunomodulatory molecules in mature cells differentiated from WJ-MSCs, therefore we aimed to characterize the extent of maintenance of the naive traits of these cells also in a highly specialized differentiated counterpart. WJ-MSCs were differentiated into hepatocyte-like cells (HLCs) with a four weeks protocol. RT-PCR, flow cytometry, IHC and ICC were performed to assess expression of key markers in both undifferentiated and differentiate…

At the roots of tolerogenicity and immune modulation: an in vitro and in situ survey on the expression of immunomodulatory molecules by Wharton’s jel…

2012

Octave Spanning Supercontinuum in Titanium Dioxide Waveguides

2018

International audience; We report on the experimental generation of an octave-spanning supercontinuum in a 2.2 cm-long titanium dioxide optical waveguide with two zero dispersion wavelengths. The resulting on-chip supercontinuum reaches the visible wavelength range as well as the mid-infrared region by using a femtosecond fiber laser pump at 1.64 µm.

Design and Realization of a Bidirectional Full Bridge Converter with Improved Modulation Strategies

2020

In this paper a Full-Bridge Converter (FBC) for bidirectional power transfer is presented. The proposed FBC is an isolated DC-DC bidirectional converter, connected to a double voltage source&mdash

Neuro-endocrine networks controlling immune system in health and disease

2014

The nervous and immune systems have long been considered as compartments that perform separate and different functions. However, recent clinical, epidemiological, and experimental data have suggested that the pathogenesis of several immune-mediated disorders, such as multiple sclerosis (MS), might involve factors, hormones, and neural mediators that link the immune and nervous system. These molecules are members of the same superfamily, which allow the mutual and bi-directional neural–immune interaction. More recently, the discovery of leptin, one of the most abundant adipocyte-derived hormones that control food intake and metabolism, has suggested that nutritional/metabolic status, acting …

Analysis of Somatosensory Cortical Responses to Different Electrotactile Stimulations as a Method Towards an Objective Definition of Artificial Senso…

2022

Sensory feedback is a critical component in many human-machine interfaces (e.g., bionic limbs) to provide missing sensations. Specifically, electrotactile stimulation is a popular feedback modality able to evoke configurable sensations by modulating pulse amplitude, duration, and frequency of the applied stimuli. However, these sensations coded by electrotactile parameters are thus far predominantly determined by subjective user reports, which leads to heterogeneous and unstable feedback delivery. Thus, a more objective understanding of the impact that different stimulation parameters induce in the brain, is needed. Analysis of cortical responses to electrotactile afference might be an effe…

Reproducibility of evoked and induced MEG responses to proprioceptive stimulation of the ankle joint

2022

Cortical processing of proprioceptive afference can be investigated by examining phase locked evoked and induced responses in cortical signals to passive movement stimuli. Reproducibility of evoked and induced responses has been studied using electroencephalography (EEG), but proprioceptive domain has received little attention. It is unclear whether evoked and induced responses to proprioceptive stimulation arising from the lower limbs are reproducible using magnetoencephalography (MEG). Nineteen healthy volunteers (18 right-foot dominant, 36.1 ± 6.6 yr, 7 females) were measured in two MEG sessions separated by 9 ± 5 days in which their right ankle was rotated intermittently using a pneumat…

Modulation of melanoma-associated antigens by monoclonal antibodies as visualized by radioimmunoelectron microscopy and radioantibody binding assay

1987

There is a wealth of information about monoclonal antibody (MAb) specificity and function on fixed tissues, yet little is known about formation and release of antigen-antibody complexes and their functional behavior in vivo. We analyzed the pathway of radiolabeled MAbs directed against melanoma-associated antigens by radioimmunoelectron microscopy (RIEM) on metabolically active cells of the melanoma cell lines SK-MEL-28, MeWo and Colo 38 at different time intervals. In parallel, binding and release of MAbs were investigated by the radioantibody binding assay (RBA). Both procedures gave essentially concordant results. Preferentially stable binding of immune complexes (ICs) to the cell surfac…

Management of Blood Pressure and Heart Rate in Patients with Acute Stroke

2017

BACKGROUND: Stroke represent one of the most devastating of all neurological diseases, affecting about 15 million people per year and is an important cause of morbidity and mortality worldwide and currently the leading cause of adult disability in developed countries. Blood pressure and heart rate may undergo several modifications in patients with both ischemic and hemorrhagic stroke in fact raised blood pressure levels may lead to cerebral edema, hematoma expansion or hemorrhagic transformation and in contrast low blood pressure can lead to increased cerebral infarction or perihematomal ischemia. In addition, ECG abnormalities and cardiac arrhythmias, especially atrial fibrillation, are re…