Search results for " multiple"
showing 10 items of 903 documents
A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility
2022
Abstract Background Over 200 genetic loci have been associated with multiple sclerosis (MS) explaining ~ 50% of its heritability, suggesting that additional mechanisms may account for the “missing heritability” phenomenon. Objective To analyze a large cohort of Italian individuals to identify markers associated with MS with potential functional impact in the disease. Methods We studied 2571 MS and 3234 healthy controls (HC) of continental Italian origin. Discovery phase included a genome wide association study (1727 MS, 2258 HC), with SNPs selected according to their association in the Italian cohort only or in a meta-analysis of signals with a cohort of European ancestry (4088 MS, 7144 HC)…
Multiple sclerosis – candidate mechanisms underlying CNS atrophy
2009
Recently it has become clear that the neuronal compartment plays a more important role than previously thought in the pathology of multiple sclerosis. Apart from demyelination, neuronal pathology is apparently largely responsible for the brain atrophy that can be observed early on and throughout the course of the disease. The loss of axons and their neurons in the course of chronic neuroinflammation is a major factor determining long-term disability in patients. The actual steps leading from immune attack against the myelin sheath to neuronal damage are not yet fully clear. Here we review key findings about direct axonal damage processes, demyelination-related neuronal pathology and cell-bo…
“Symptoms associated with environmental factors” (SAEF) – Towards a paradigm shift regarding “idiopathic environmental intolerance” and related pheno…
2020
Health conditions characterized by symptoms associated with chemical, physical and biological environmental factors unrelated to objectifiable pathophysiological mechanisms are often labelled by the general term “idiopathic environmental intolerances”. More specific, exposure-related terms are also used, e.g. “multiple chemical sensitivities”, “electromagnetic hypersensitivity” and “candidiasis hypersensitivity”. The prevalence of the conditions varies from a few up to more than 50%, depending on definitions and populations. Based on evolving knowledge within this field, we provide arguments for a paradigm shift from terms focusing on exposure and intolerance/(hyper-)sensitivity towards a t…
Search for events with large missing transverse momentum, jets, and at least two tau leptons in 7 TeV proton–proton collision data with the ATLAS det…
2012
A search for events with large missing transverse momentum, jets, and at least two tau leptons has been performed using 2 fb[superscript −1] of proton–proton collision data at √s = 7 TeV recorded with the ATLAS detector at the Large Hadron Collider. No excess above the Standard Model background expectation is observed and a 95% CL upper limit on the visible cross section for new phenomena is set, where the visible cross section is defined by the product of cross section, branching fraction, detector acceptance and event selection efficiency. A 95% CL lower limit of 32 TeV is set on the gauge-mediated supersymmetry breaking (GMSB) scale Λ independent of tan β. These limits provide the most s…
Search for Neutral Higgs Bosons in Events with Multiple Bottom Quarks at the Tevatron
2012
The combination of searches performed by the CDF and D0 collaborations at the Fermilab Tevatron Collider for neutral Higgs bosons produced in association with b quarks is reported. The data, corresponding to 2.6fb -1 of integrated luminosity at CDF and 5.2fb -1 at D0, have been collected in final states containing three or more b jets. Upper limits are set on the cross section multiplied by the branching ratio varying between 44 pb and 0.7 pb in the Higgs boson mass range 90 to 300 GeV, assuming production of a narrow scalar boson. Significant enhancements to the production of Higgs bosons can be found in theories beyond the standard model, for example, in supersymmetry. The results are int…
MUSIC-LS Modal Channel Estimation for an OFDM-OQAM System
2008
Orthogonal frequency division multiplexing based on offset quadrature amplitude modulation (OFDM-OQAM) signaling over frequency selective multipath channels shows inter-symbol interference (ISI) and Inter-Channel Interference (ICI) that degrade its performance. Channel equalization and channel estimation are needed to combat these intrinsic interferences. In this paper a novel modal channel estimator based on the MUltiple signal classification (MUSIC) and least squares (LS) algorithms for a wideband passband OFDM-OQAM signaling over static multipath channels is presented. The effects of the frequency selective channel on the received signal are described considering a wideband OFDM-OQAM sys…
MUSIC-based modal channel estimation for wideband OFDM-OQAM
2008
Orthogonal frequency division multiplexing based on offset quadrature amplitude modulation (OFDM-OQAM) over wideband frequency selective multipath channels suffers from inter-symbol interference (ISI) and inter-carrier interference (ICI) that degrade its performance. Channel estimation and equalization are needed to combat these interferences. In this paper a novel channel estimator for passband OFDM-OQAM signaling over wideband multipath channels, which is based on multiple signal classification (MUSIC) with the Spatial Smoothing technique is presented. Numerical simulation results are presented in the low number of subcarriers, i.e. wideband, scenario.
Warming and acidification effects on biofilm/grazer interaction in an early-stage rocky intertidal community
2016
Anthropogenic carbon dioxide (CO2) emissions are increasing greenhouse effects and changing seawater carbonate chemistry, leading to ocean warming and acidification. Increasing temperature and decreasing seawater pH can potentially interact to cause changes in species interactions and community shifts. To understand how ocean warming and acidification may affect the early stages of an intertidal community in the Mediterranean, we set up an in situ experiment and assessed potential changes in grazer density andbiofilm composition by manipulating temperature on bare rock plots (10x10cm)in two locations along a natural coastal CO2 gradient (Low pH: 7.8 pH, and Ambient:8.1 pH) off Vulcano Islan…
DARATUMUMAB, BORTEZOMIB AND DEXAMETHASONE (DVD) VS BORTEZOMIB AND DEXAMETHASONE (VD) IN RELAPSED OR REFRACTORY MULTIPLE MYELOMA (RRMM): EFFICACY AND …
2017
8036 Background: Daratumumab (D), a human, CD38-targeting mAb, is well tolerated and induces deep and durable responses in patients (pts) with RRMM. We provide an update of CASTOR (NCT02136134), a multicenter, phase 3, randomized study of DVd vs Vd in RRMM. Methods: All pts received ≥1 prior line of therapy (LOT) and were administered 8 cycles (Q3W) of Vd (1.3 mg/m2 SC bortezomib on days 1, 4, 8, and 11; 20 mg PO/IV dexamethasone on days 1-2, 4-5, 8-9, and 11-12) ± D (16 mg/kg IV once weekly in Cycles 1-3, every 3 weeks for Cycles 4-8, then every 4 weeks until progression). Bortezomib-refractory pts were ineligible. Minimal residual disease (MRD) was assessed upon suspected CR and at 6 and…
Apolipoprotein E genotype does not influence the progression of multiple sclerosis
2003
OBJECTIVE: To investigate the association between apolipoprotein E (APOE) polymorphisms and the progression of MS. METHODS: We investigated 428 subjects affected by clinically defined MS, with a disease duration of at least three years. We collected data concerning the age at onset of MS, clinical type, disease duration and disability according to the expanded disability status scale (EDSS). We also calculated the progression index (PI) to evaluate disease progression. APOE genotyping and the -491 A/T polymorphism of the APOE promoter were determined. RESULTS: No association was observed between the APOE epsilon4 allele and clinical characteristics of our study population. We also investiga…