Search results for " multiple"
showing 10 items of 903 documents
Una nuova applicazione della Comparative Multiplex Dosage Analysis (CMDA)
2011
La Comparative Multiplex Dosage Analysis (CMDA) è una tecnica utilizzata per l’analisi di delezioni o duplicazioni di specifiche regioni del genoma (Gable et al. 2003 Hum Mutat 21:379-386). Il metodo si basa su di un’analisi quantitativa delle aree dei picchi di un elettroferogramma ottenuto da elettroforesi capillare condotta su frammenti di DNA amplificati con PCR e marcati con specifici fluorocromi. La presenza di sbilanciamenti è , in particolare, accertata misurando il rapporto tra le aree dei picchi corrispondenti alla regione da analizzare e una regione del genoma la cui dose è nota. In studi precedenti noi abbiamo applicato questa tecnica all’analisi di delezioni e duplicazioni di s…
Metilazione del DNA in artrite reumatoide
2005
Lo stato di metilazione del DNA genomico e del gene PTHrP è stato valutato con tecniche molecolari e citogenetiche in artrite reumatoide (AR), patologia autoimmune caratterizzata anche da alta incidenza di linfomi e da ipercalcemia per overespressione del gene PTHrP. La metilazione del DNA, infatti, ha un ruolo critico nello sviluppo delle malattie neoplastiche; il gene PTHrP avendo tre promotori uno dei quali contiene un’isola CpG è un buon candidato per la deregolazione da alterato pattern di metilazione locale. Le indagini sulla metilazione genomica, condotte su DNA estratto da sangue periferico di pazienti e di donatori e amplificato in reazioni di Methylation-Sensitive Arbitrarily Prim…
Landform classification: a high-performing mapping unit partitioning tool for landslide susceptibility assessment—a test in the Imera River basin (no…
2022
In landslide susceptibility studies, the type of mapping unit adopted affects the obtained models and maps in terms of accuracy, robustness, spatial resolution and geomorphological adequacy. To evaluate the optimal selection of these units, a test has been carried out in an important catchment of northern Sicily (the Imera River basin), where the spatial relationships between a set of predictors and an inventory of 1608 rotational/translational landslides were analysed using the multivariate adaptive regression splines (MARS) method. In particular, landslide susceptibility models were prepared and compared by adopting four different types of mapping units: the largely adopted grid cells (PX…
Palermo 2010 - Campagna di monitoraggio sismo-acustico sottomarino dell’area epicentrale del terremoto di Palermo del 6 settembre 2002
2010
Waveforms clustering of small magnitude earthquakes recorded in the Northern Sicilian offshore: evidence of multiplets
2011
Modalità di invio delle informazioni e la percezione dell’automobilista: un’analisi sperimentale sui pannelli a messaggio variabile
2007
Anche in Italia, come da decenni in altri Paesi, i pannelli a messaggio variabile (PMV) stanno trovando una sempre più ampia diffusione, sia in ambito urbano che extraurbano: essi consentono di inviare, in tempo reale, informazioni di qualsiasi genere agli automobilisti in transito lungo le strade ove tali pannelli sono posizionati. I messaggi trasmessi riguardano notizie relative allo stato della viabilità (condizioni di congestione, blocchi stradali per incidenti, lavori in corso) ed informazioni di varia natura (segnalazioni turistiche, news di aggiornamento, pubblicità, ect.). È noto dai principi della Biodinamica dei fattori umani come la percezione del messaggio sia fortemente influen…
Exergoeconomic analysis as a tool for supporting the design and operation of multiple chiller systems in air conditioning applications.
2019
Multiple-Chillers systems represent viable solutions for medium/large-scale air conditioning applications. In these systems, however, design and energy savings are highly affected by the configuration and operation strategies adopted. For instance, when considering multiple chillers of same size, “symmetric” or “sequential” load sharing strategies are two viable options. Conversely, when considering chillers of different sizes, a wide combination of chillers cooling capacities may be adopted. It is apparent that an integrated analysis of the design and operation of these systems should be carried out in order to achieve profitable energy saving. With this respect, Exergoeconomics, which res…
Advanced energetics of a Multiple Effects Evaporation (MEE) desalination plant Part I: 2nd principle analysis by a zooming representation at single-e…
2010
This paper represents the Part I of a paper in two parts, aimed at proposing a 2nd principle and thermoeconomic analysis for a Multiple Effects Evaporation (MEE) process and discussing solutions for optimization and energy saving. After a brief analysis of the thermochemical fundamentals of desalination, the minimum theoretical work of separation is introduced to represent a reference condition for the assessment of plants' efficiency. A forward feed MEE configuration is then analysed, abandoning the conventional approach to “at overall plant-level”-analysis; a zooming strategy, based on focusing on the physical model of a generic stage (i.e. effect), is preferred to best recognize the marg…
ALTERNATIVE MODELS FOR BUILDING ENERGY PERFORMANCE ASSESSMENT
2020
The research activity carried out during the three years of the PhD course attended, at the Engineering Department of the University of Palermo, was aimed at the identification of an alternative predictive model able to solve the traditional building thermal balance in a simple but reliable way, speeding up any first phase of energy planning. Nowadays, worldwide directives aimed at reducing energy consumptions and environmental impacts have focused the attention of the scientific community on improving energy efficiency in the building sector. The reduction of energy consumption and CO2 emissions for heating and cooling needs of buildings is an important challenge for the European Union, be…
Selection of Series System Components to Maximize Reliability
2010
The paper tackles the problem of maximizing the reliability of a series system by an opportune choice of components. Each type of component must be selected among the available alternatives for that component whereas a fixed amount of budget can not be overcome. The problem can be formulated by a binary non linear programming model and it is equivalent to a knapsack problem with multiple-choice constraints, well known to be NP-hard. An exact algorithm is proposed for solving large dimension problems to the optimum in a short time. The algorithm efficiency is finally compared with the recent heuristics proposed in literature to approach the same problem.