Search results for " multiple"
showing 10 items of 903 documents
De novo CCND2 mutations leading to stabilization of cyclin D2 cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
2014
Activating mutations in genes encoding phosphatidylinositol 3-kinase (PI3K)-AKT pathway components cause megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome (MPPH, OMIM 603387)(1-3). Here we report that individuals with MPPH lacking upstream PI3K-AKT pathway mutations carry de novo mutations in CCND2 (encoding cyclin D2) that are clustered around a residue that can be phosphorylated by glycogen synthase kinase 313 (GSK-3 beta)(4). Mutant CCND2 was resistant to proteasomal degradation in vitro compared to wild-type CCND2. The PI3K-AKT pathway modulates GSK-3 beta activity(4), and cells from individuals with PIK3CA, PIK3R2 or AKT3 mutations showed similar CCND2 accumulation. CCND…
Efficient Power Allocation for Multi-Cell Uplink NOMA Network
2019
Digital technologies are rapidly shaping the modern concepts of urbanization. It is a key element of developing practical smart cities of the future. In fact, they are the catalyst for the increasing networking of all areas of life in a smart city. Recent development in the domain of communication technologies has opened new avenues to realize the concept of smart cities. One of such communication technology is non-orthogonal multiple access (NOMA) for future cellular communications. This article, therefore, focuses on the interference management of uplink cellular NOMA systems. Specifically, we propose a power optimization technique for NOMA to improve the sum-rate in a multi-cell environm…
FLUMO: FLexible Underwater MOdem
2019
The last years have seen a growing interest in underwater acoustic communications because of its applications in marine research, oceanography, marine commercial operations, the offshore oil industry and defense. High-speed communication in the underwater acoustic channel has been challenging because of limited bandwidth, extended multipath, refractive properties of the medium, severe fading, rapid time variation and large Doppler shifts. In this paper, we show an implementation of a flexible Software-Defined Acoustic (SDA) underwater modem, where modulation parameters are completely tunable to optimize performance. In particular, we develop the system architecture following two key ideas. …
Extracellular vesicles from CS fluid are possible biomarkers of multiple sclerosis disease status
2018
Multiple sclerosis (MS) is an autoimmune disease and several researches have been focused on identifying molecular biomarkers that could reflect its heterogeneous clinical course and determine the best treatment option for patients. Some studies identified extracellular vesicles (EVs) in both the cerebrospinal fluid (CSF) and also in blood samples of patients affected by inflammatory neurodegenerative diseases and multiple sclerosis. To monitor the disease onset and its progression we compared the amount of CSF-EVs and their surface markers in subjects affected by either MS or other neurological disorders correlating the EVs with clinical indicators of MS disease severity. EVs isolated by u…
Effect of extracellular vesicles from CSF of multiple sclerosis patients and healthy controls on astrocytes in culture
2017
INTRODUCTION Secretion of extracellular vesicles (EVs) and EV-mediated exchange of molecules among brain cells, under physiological conditions, has been described years ago. At the same time, ability of EVs to transfer proteins and nucleic acids to the surrounding cells, thus modifying their phenotypes, has been clearly demonstrated for tumor cells of different origins, including brain cancers. More recently, involvement of EVs in pathological processes affecting the Central Nervous System (CNS), and their capacity of transferring damaging cargoes have been also suggested. To explore these functions, we exposed primary cultures of astrocytes to EVs isolated from cerebral spinal fluid (CSF) …
Using eye-movement modelling examples to improve critical reading of multiple webpages on a conflicting topic
2022
This project investigates the effects of an EMME intervention on undergraduates' sourcing when reading conflicting multiple texts on the Internet. Dependent variables: eye-movements on SERP, webs header, texts authors, and texts; use of source information in summaries; ideas from texts in summaries.
Cladding-Pumped Er/Yb-Co-Doped Fiber Amplifier for Multi-Channel Operation
2022
The Institute of Solid State Physics, University of Latvia, as a Center of Excellence, has received funding from the European Union’s Horizon 2020 Framework Programme H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 under grant agreement No. 739508, project CAMART2. We express our gratitude to rer. nat. Nicoletta Haarlammert from Fraunhofer Institute for Applied Optics and Precision Engineering IOF for the refractive index measurements of ytterbium/erbium-co-doped fibers. This work is supported by the European Regional Development Fund project No. 1.1.1.1/18/A/068.
The necropolis of Ensisheim/Reguisheimerfeld (Haut-Rhin) : illustration of the Late Bronze Age funerary practices in Alsace
2007
In 2000, the preventive excavation of the Ensisheim/Reguisheimerfeld site (Haut-Rhin), carried out by the ANTEA SARL company, brought to light 87 funerary structures belonging to a cremation necropolis dating from the beginning of the Late Bronze Age (around 1350-1050 BC). Following study of the material, 3 successive chronological phases and a possible cultural "faciès" centred on the bend in the Rhine at Basel, Switzerland, were distinguished. The archaeo-anthropological study of the burnt bones revealed, among other things, the existence of a large number of multiple graves and of socially immature members of the society, phenomena rarely observed in the region. The analysis of the inter…
Study on the financial performance of companies operating in the pharmaceutical industry in romania
2016
Abstract The study aims at determining the financial performance of companies in the pharmaceutical industry between 2009 and 2014 by means of the indicator of the financial return rate, using multiple linear regressions as research method. By analysing the evolution of the share of companies in the pharmaceutical industry based on the trend of the financial rate of return, we can estimate that the number of entities that resort to supporting the financial activities from loans and liabilities is growing in the period under analysis. This is due mainly to the liquidity crisis faced by entities, as a result of the high recovery duration of debts. Also, using the multiple linear regression we…
V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenou…
2010
Abstract Imatinib mesylate (imatinib), a competitive inhibitor of the BCR-ABL tyrosine kinase, is highly effective against chronic myelogenous leukemia (CML) cells. However, because 20–30% of patients affected by CML display either primary or secondary resistance to imatinib, intentional activation of Vγ9Vδ2 T cells by phosphoantigens or by agents that cause their accumulation within cells, such as zoledronate, may represent a promising strategy for the design of a novel and highly innovative immunotherapy capable to overcome imatinib resistance. In this study, we show that Vγ9Vδ2 T lymphocytes recognize, trogocytose, and efficiently kill imatinib-sensitive and -resistant CML cell lines pre…