Search results for " multiplex"

Rapid differentiation, in situ detection and monitoring of sourdough lactobacilli from the Abruzzo region (central Italy)

2006

Neuroblastoma after Childhood: Prognostic Relevance of Segmental Chromosome Aberrations, ATRX Protein Status, and Immune Cell Infiltration

2014

AbstractNeuroblastoma (NB) is a common malignancy in children but rarely occurs during adolescence or adulthood. This subgroup is characterized by an indolent disease course, almost uniformly fatal, yet little is known about the biologic characteristics. The aim of this study was to identify differential features regarding DNA copy number alterations, α-thalassemia/mental retardation syndrome X-linked (ATRX) protein expression, and the presence of tumor-associated inflammatory cells. Thirty-one NB patients older than 10 years who were included in the Spanish NB Registry were considered for the current study; seven young and middle-aged adult patients (range 18-60 years) formed part of the c…

Xq27 FRAXA Locus is a Strong Candidate for Dyslexia: Evidence from a Genome-Wide Scan in French Families

2012

Dyslexia is a frequent neurodevelopmental learning disorder. To date, nine susceptibility loci have been identified, one of them being DYX9, located in Xq27. We performed the first French SNP linkage study followed by candidate gene investigation in dyslexia by studying 12 multiplex families (58 subjects) with at least two children affected, according to categorical restrictive criteria for phenotype definition. Significant results emerged on Xq27.3 within DYX9. The maximum multipoint LOD score reached 3,884 between rs12558359 and rs454992. Within this region, seven candidate genes were investigated for mutations in exonic sequences (CXORF1, CXORF51, SLITRK2, FMR1, FMR2, ASFMR1, FMR1NB), al…

Cladding-Pumped Erbium/Ytterbium Co-Doped Fiber Amplifier for C-Band Operation in Optical Networks

2021

Space-division multiplexing (SDM) attracts attention to cladding-pumped optical amplifiers, but they suffer from a low pump power conversion efficiency. To address this issue, ytterbium (Yb3+) and erbium (Er3+) co-doping is considered as an effective approach. However, it changes the gain profile of Er3+-doped fiber amplifiers and induces the gain difference between optical wavelengths in the C-band, significantly limiting the effective band of the dense wavelength-division multiplexed (DWDM) system. This paper is devoted to a detailed study of a cladding-pumped Er3+/Yb3+ co-doped fiber amplifier (EYDFA) through numerical simulations aiming to identify a configuration, before assembling a s…

Optical flip-flop memory and routing operation based on polarization bistability in optical fiber

2014

A polarization bistability and hysteresis cycle phenomenon is demonstrated in optical fibers thanks to a counter-propagating four-wave mixing interaction. Based on this process, we successfully report the proof-of-principle of an optical flip-flop memory and a 10-Gbit/s routing operation.

0.48Tb/s (12x40Gb/s) WDM transmission and high-quality thermo-optic switching in dielectric loaded plasmonics

2012

We demonstrate Wavelength Division Multiplexed (WDM)-enabled transmission of 480Gb/s aggregate data traffic (12x40Gb/s) as well as high-quality 1x2 thermo-optic tuning in Dielectric-Loaded Surface Plasmon Polariton Waveguides (DLSPPWs). The WDM transmission characteristics have been verified through BER measurements by exploiting the heterointegration of a 60 mu m-long straight DLSPPW on a Silicon-on-Insulator waveguide platform, showing error-free performance for six out of the twelve channels. High-quality thermo-optic tuning has been achieved by utilizing Cycloaliphatic-Acrylate-Polymer as an efficient thermo-optic polymer loading employed in a dual-resonator DLSPPW switching structure, …

All-optical nonlinear processing of both polarization state and intensity profile for 40 Gbit/s regeneration applications

2011

International audience; In this paper, we report all-optical regeneration of the state of polarization of a 40-Gbit/s return-to-zero telecommunication signal as well as its temporal intensity profile and average power thanks to an easy-to-implement, all-fibered device. In particular, we experimentally demonstrate that it is possible to obtain simultaneously polarization stabilization and intensity profile regeneration of a degraded light beam thanks to the combined effects of counterpropagating four-wave mixing, self-phase modulation and normal chromatic dispersion taking place in a single segment of optical fiber. All-optical regeneration is confirmed by means of polarization and bit-error…

Fiber-pigtailed temperature sensors based on dielectric-loaded plasmonic waveguide-ring resonators.

2012

We demonstrate optical fiber-pigtailed temperature sensors based on dielectric-loaded surface plasmon-polariton waveguide-ring resonators (DLSPP-WRRs), whose transmission depends on the ambient temperature. The DLSPP-WRR-based temperature sensors represent polymer ridge waveguides (~1×1 µm(2) in cross section) forming 5-µm-radius rings coupled to straight waveguides fabricated by UV-lithography on a 50-nm-thick gold layer atop a 2.3-µm-thick CYTOP layer covering a Si wafer. A broadband light source is used to characterize the DLSPP-WRR wavelength-dependent transmission in the range of 1480-1600 nm and to select the DLSPP-WRR component for temperature sensing. In- and out-coupling single-mod…

Polarization insensitive wavelength conversion of 40 Gb/s DPSK signals in a silicon germanium waveguide

2015

We demonstrate polarization insensitive FWM-based wavelength conversion of 40Gb/s DPSK signals in a SiGe waveguide, with 0.42-dB polarization-dependent loss. A 1.5-dB Dower nenaltv was measured at a BER of 10−9.

CMOS plasmonics in WDM data transmission: 200 Gb/s (8 × 25Gb/s) transmission over aluminum plasmonic waveguides

2018

We demonstrate wavelength-division-multiplexed (WDM) 200 Gb/s (8 × 25 Gb/s) data transmission over 100 μm long aluminum (Al) surface-plasmon-polariton (SPP) waveguides on a Si3N4 waveguide platform at telecom wavelengths. The Al SPP waveguide was evaluated in terms of signal integrity by performing bit-error-rate (BER) measurements that revealed error-free operation for all eight 25 Gb/s non-return-to-zero (NRZ) modulated data channels with power penalties not exceeding 0.2 dB at 10−9. To the best of our knowledge, this is the first demonstration of WDM enabled data transmission over complementary-metal-oxide-semiconductor (CMOS) SPP waveguides fueling future development of CMOS compatible …