Search results for " norma"

showing 10 items of 623 documents

Removing Batch Effects from Longitudinal Gene Expression - Quantile Normalization Plus ComBat as Best Approach for Microarray Transcriptome Data

2016

International audience; Technical variation plays an important role in microarray-based gene expression studies, and batch effects explain a large proportion of this noise. It is therefore mandatory to eliminate technical variation while maintaining biological variability. Several strategies have been proposed for the removal of batch effects, although they have not been evaluated in large-scale longitudinal gene expression data. In this study, we aimed at identifying a suitable method for batch effect removal in a large study of microarray-based longitudinal gene expression. Monocytic gene expression was measured in 1092 participants of the Gutenberg Health Study at baseline and 5-year fol…

Male0301 basic medicineMolecular biologyMicroarrayslcsh:MedicineGene ExpressionPolynomialsMonocytesMathematical and Statistical Techniques0302 clinical medicineLongitudinal StudiesProspective Studieslcsh:ScienceOligonucleotide Array Sequence AnalysisGeneticsPrincipal Component Analysis[SDV.MHEP] Life Sciences [q-bio]/Human health and pathologyMultidisciplinaryGenomicsReplicateMiddle AgedRegressionRNA isolationBioassays and Physiological Analysis030220 oncology & carcinogenesisPhysical SciencesPrincipal component analysisFemaleRNA hybridizationDNA microarrayTranscriptome AnalysisStatistics (Mathematics)Research ArticleAdultComputational biologyBiologyBiomolecular isolationGeneralized linear mixed model03 medical and health sciencesDeming regressionExtraction techniquesGeneticsHumansStatistical MethodsAgedQuantile normalizationMolecular probe techniquesGene Expression Profilinglcsh:RBiology and Life SciencesComputational BiologyGenome AnalysisProbe hybridizationRNA extractionResearch and analysis methodsGene expression profilingMolecular biology techniquesAlgebra030104 developmental biologyNonlinear DynamicsMultivariate Analysislcsh:QMathematics[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

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SARS CoV2 infection _The longevity study perspectives

2021

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MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews

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Cross-species transcriptomic analysis elucidates constitutive aryl hydrocarbon receptor activity

2014

Background Research on the aryl hydrocarbon receptor (AHR) has largely focused on variations in toxic outcomes resulting from its activation by halogenated aromatic hydrocarbons. But the AHR also plays key roles in regulating pathways critical for development, and after decades of research the mechanisms underlying physiological regulation by the AHR remain poorly characterized. Previous studies identified several core genes that respond to xenobiotic AHR ligands across a broad range of species and tissues. However, only limited inferences have been made regarding its role in regulating constitutive gene activity, i.e. in the absence of exogenous ligands. To address this, we profiled transc…

MaleHEPATIC GENE-EXPRESSION413 Veterinary scienceMedical and Health SciencesTranscriptomeDIOXIN RECEPTORMice0302 clinical medicineTCDD-induced toxicityReceptorsTranscriptional regulationABNORMAL LIVER DEVELOPMENT2.1 Biological and endogenous factorsCluster AnalysisAetiologyReceptorAH RECEPTORIN-VIVOAryl hydrocarbon receptorGeneticsRegulation of gene expression0303 health sciencesBiological Sciencesrespiratory systemCore-gene batteryAryl HydrocarbonOrgan Specificity030220 oncology & carcinogenesisAHR endogenous ligands2378-TETRACHLORODIBENZO-P-DIOXIN TCDDSignal transductionResearch ArticleBiotechnologySignal TransductionProtein BindingBioinformatics1.1 Normal biological development and functioningeducationRAT-LIVERConstitutive gene expressionBiologyMICE LACKING03 medical and health sciencesSpecies SpecificityUnderpinning researchInformation and Computing SciencesGeneticsAnimals030304 developmental biologyAryl hydrocarbon receptor activityGene Expression ProfilingComputational BiologyAryl hydrocarbon receptorCELL-CYCLE CONTROLRatsrespiratory tract diseasesGene expression profilingReceptors Aryl HydrocarbonGene Expression RegulationSUBCHRONIC EXPOSUREbiology.proteinDigestive DiseasesTranscriptome

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Single-cell analysis of the ventricular-subventricular zone reveals signatures of dorsal and ventral adult neurogenesis

2021

The ventricular-subventricular zone (V-SVZ), on the walls of the lateral ventricles, harbors the largest neurogenic niche in the adult mouse brain. Previous work has shown that neural stem/progenitor cells (NSPCs) in different locations within the V-SVZ produce different subtypes of new neurons for the olfactory bulb. The molecular signatures that underlie this regional heterogeneity remain largely unknown. Here, we present a single-cell RNA-sequencing dataset of the adult mouse V-SVZ revealing two populations of NSPCs that reside in largely non-overlapping domains in either the dorsal or ventral V-SVZ. These regional differences in gene expression were further validated using a single-nucl…

MaleNervous systemMouseTransgenicneuroscienceMiceNeural Stem CellsLateral VentriclesBiology (General)education.field_of_studyGeneral NeuroscienceNeurogenesisQRGeneral MedicineStem Cells and Regenerative Medicineadult neurogenesismedicine.anatomical_structureolfactory bulbNeurologicalMedicineStem Cell Research - Nonembryonic - Non-HumanFemaleSingle-Cell AnalysisStem cellMicrodissectionneuroblastResearch ArticleQH301-705.51.1 Normal biological development and functioningNeurogenesisSciencePopulationregenerative medicineSubventricular zoneMice TransgenicBiologysingle-cell sequencingGeneral Biochemistry Genetics and Molecular BiologyNeuroblaststem cellsUnderpinning researchGeneticsmedicineAnimalseducationmouseGeneral Immunology and MicrobiologyNeurosciencesStem Cell ResearchOlfactory bulbstem cellnervous systemBiochemistry and Cell BiologyNeuronTranscriptomeNeuroscienceNeuroscienceregional differenceseLife

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e-Health-based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study

2017

Essentials e-Health based health care by an expert centre may advance management of oral anticoagulation. Outcome of patients was compared between an e-health based coagulation service and regular care. Patients in the coagulation service cohort experienced a significantly better clinical outcome. Lower risk for adverse events was related to anticoagulation-specific and non-specific outcome. SummaryBackground Management of oral anticoagulation (OAC) therapy is essential to minimize adverse events in patients receiving vitamin K-antagonists (VKAs). Data on the effect of e-health-based anticoagulation management systems on the clinical outcome of OAC patients are limited. Objectives To compar…

MalePediatricsVitamin KAdministration OralComorbidity030204 cardiovascular system & hematologyRate ratioSERVICE0302 clinical medicineRisk FactorsGermanyUSUAL MEDICAL-CAREClinical endpointProspective Studies030212 general & internal medicineAged 80 and overOUTCOMESHazard ratioDABIGATRANHematologyMiddle AgedHospitalizationTreatment OutcomeCohortdelivery of healthcareFemaleepidemiologyPatient SafetytelemedicineCohort studymedicine.drugmedicine.medical_specialtyanticoagulantsHemorrhageLower riskpatient outcome assessmentWARFARIN03 medical and health sciencesThromboembolismmedicineNONVALVULAR ATRIAL-FIBRILLATIONHumansQUALITYInternational Normalized RatioAdverse effectBlood CoagulationMETAANALYSISAgedProportional Hazards ModelsRivaroxabanbusiness.industrySTROKE PREVENTIONRIVAROXABANbusinessFollow-Up Studies

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Postural control and balance in a cohort of healthy people living in Europe: An observational study

2018

Abstract In the past 20 years, posturography has been widely used in the medical field. This observational study aimed to report the values derived from posturography of a wide set of healthy subjects from various European countries using a plantar pressure platform and a standardized method of measurement. A random cluster sampling of 914 healthy subjects aged between 7.0 and 85.99 years, stratified by age, was carried out. To provide percentile values of our cohort, data were processed to obtain 3 curves corresponding to the following percentiles: 25th, 50th, 75th, and the interquartile range. Distance-weighted least squares method was used to represent the percentile on appropriate graph…

MalePercentileAgingpostural controlCohort Studies0302 clinical medicineReference ValuesPostural Balance80 and overMedicineAge FactorReference ValueYoung adultChildPostural BalanceAged 80 and over6600balance ; normative data ; normative values ; postural control ; posturographyMedicine (all)posturographyAge FactorsGeneral MedicineMiddle Agednormative dataHealthy VolunteerHealthy VolunteersEuropenormative valuesVestibular Function TestCohortFemaleHumanResearch ArticleCohort studyAdultmedicine.medical_specialtyBiometryAdolescentPostureObservational Study03 medical and health sciencesYoung AdultPhysical medicine and rehabilitationAdolescent; Adult; Age Factors; Aged; Aged 80 and over; Aging; Biometry; Child; Cohort Studies; Europe; Female; Healthy Volunteers; Humans; Least-Squares Analysis; Male; Middle Aged; Posture; Reference Values; Vestibular Function Tests; Young Adult; Postural Balance; Medicine (all)HumansLeast-Squares AnalysisBalance (ability)AgedLeast-Squares AnalysiSettore M-EDF/02 - Metodi E Didattiche Delle Attivita' Sportivebusiness.industryPosturographybalance030229 sport sciencesVestibular Function TestsObservational studyCohort Studiebusiness030217 neurology & neurosurgery

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Subtherapeutic Anticoagulation Control under Treatment with Vitamin K-Antagonists—Data from a Specialized Coagulation Service

2019

AbstractIn contrast to overanticoagulation, evidence on risk factors and outcome of subtherapeutic oral anticoagulation (OAC) with vitamin K-antagonists (VKAs) under optimum care is limited. We investigated the clinical phenotype, anticoagulation control, and clinical outcome of 760 VKA patients who received OAC therapy by a specialized coagulation service in the thrombEVAL study (NCT01809015). During 281,934 treatment days, 278 patients experience ≥ 1 episode of subtherapeutic anticoagulation control and had lower quality of OAC therapy compared to 482 patients without subtherapeutic international normalized ratio: 67.6%, interquartile range (IQR) 54.9%/76.8% versus 81.0%, IQR 68.5%/90.4%;…

MaleQuality Control0301 basic medicineVitaminmedicine.medical_specialtyVitamin KAdministration OralComorbidity030204 cardiovascular system & hematologyVitamin k03 medical and health scienceschemistry.chemical_compound0302 clinical medicineFibrinolytic AgentsRecurrenceRisk FactorsInterquartile rangeInternal medicineAtrial FibrillationmedicineHumansThrombolytic TherapyInternational Normalized RatioBlood CoagulationStrokeAgedProportional Hazards ModelsAged 80 and overbusiness.industryProportional hazards modelCase-control studyAnticoagulantsHematologyMiddle Agedmedicine.diseaseComorbidityPhenotypeTreatment Outcome030104 developmental biologyCoagulationchemistryCase-Control StudiesFemalebusinessFollow-Up StudiesThrombosis and Haemostasis

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Enhanced thrombin generation in patients with cirrhosis-induced coagulopathy.

2010

Summary. Background: Prothrombin time (PT) and the international normalized ratio (INR) are still routinely measured in patients with liver cirrhosis to ‘assess’ their bleeding risk despite the lack of correlation with the two. Thrombin generation (TG) assays are global assays of coagulation that are showing promise in assessing bleeding and thrombosis risks. Aim: To study the relationship between the INR and TG profiles in cirrhosis-induced coagulopathy. Methods: Seventy-three patients with cirrhosis were studied. All TG parameters were compared with those from a normal control group. Contact activation was prevented using corn trypsin inhibitor. TG was also assayed in the presence of Prot…

MaleRiskmedicine.medical_specialtyPathologyCirrhosisHemorrhageGastroenterologyThrombin generationLag timeFibrinolytic AgentsInternal medicinemedicineCoagulopathyHumansIn patientInternational Normalized RatioBlood CoagulationAgedbusiness.industryThrombinAnticoagulantsHematologyBlood Coagulation DisordersMiddle Agedmedicine.diseaseThrombosisFibrosisCoagulationLiverIntercellular Signaling Peptides and ProteinsFemalebusinessPeptidesProtein Cmedicine.drugProtein CJournal of thrombosis and haemostasis : JTH

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Incidence of thromboembolic complications in patients with atrial fibrillation or mechanical heart valves with a subtherapeutic international normali…

2012

Subtherapeutic international normalized ratio (INR) is frequently encountered in clinical practice, and patients with high-risk atrial fibrillation (AF) and with mechanical heart valve (MHV) with inadequate anticoagulation may be exposed to an increased risk of thromboembolic events (TE). However, there are no prospective data evaluating this risk. Consecutive patients with a history of stable anticoagulation, but with a subtherapeutic INR, were prospectively included. Data on use and dose of low-molecular weight heparin (LMWH) bridging therapy were collected. The incidence of objectively confirmed TE and of major bleeding events within 90 days after the index INR was assessed. Five hundred…

MaleRiskmedicine.medical_specialtyPopulationvenous thromboembolismHemorrhageComorbidityThrombophiliaFollow-Up StudiePostoperative ComplicationsInternal medicineThromboembolismAtrial FibrillationmedicineHumansThrombophiliaProspective StudiesInternational Normalized RatioeducationProspective cohort studyAgedAged 80 and overHeart Valve Prosthesis Implantationeducation.field_of_studybusiness.industryIncidence (epidemiology)IncidenceMedicine (all)WarfarinAnticoagulantAnticoagulantsAtrial fibrillationHematologyHeparin Low-Molecular-WeightMiddle Agedmedicine.diseaseConfidence intervalSurgeryProspective StudieHeart Valve ProsthesiHeart Valve ProsthesisFemalePostoperative ComplicationWarfarinbusinessCohort studymedicine.drugFollow-Up StudiesHuman

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Evaluation of Deep Neural Networks for Semantic Segmentation of Prostate in T2W MRI

2020

In this paper, we present an evaluation of four encoder&ndash

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