Search results for " norma"
showing 10 items of 623 documents
Working Memory Function in Children with Single Side Deafness Using a Bone-Anchored Hearing Implant: A Case-Control Study
2018
The importance of a good hearing function to preserve memory and cognitive abilities has been shown in the adult population, but studies on the pediatric population are currently lacking. This study aims at evaluating the effects of a bone-anchored hearing implant (BAHI) on speech perception, speech processing, and memory abilities in children with single side deafness (SSD). We enrolled <i>n</i> = 25 children with SSD and assessed them prior to BAHI implantation, and at 1-month and 3-month follow-ups after BAHI implantation using tests of perception in silence and perception in phonemic confusion, dictation in silence and noise, and working memory and short-term memory function…
Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain
2009
Calcium sensing receptor (CaSR), isolated for the first time from bovine and human parathyroid, is a G-protein-coupled receptors that has been involved in diverse physiological functions. At present a complete in vivo work on the identification of CaSR mRNA-expressing cells in the adult brain lacks and this investigation was undertaken in order to acquire more information on cell type expressing CaSR mRNA in the rat brain and to analyse for the first time its expression in different experimental models of brain injury. The expression of CaSR mRNAs was found mainly in scattered cells throughout almost all the brain regions. A double labeling analysis showed a colocalization of CaSR mRNA expr…
Variables affecting the quality of anticoagulation in atrial fibrillation patients newly initiating vitamin K antagonists: insights from the national…
2021
Abstract Aims Vitamin K antagonists (VKAs) are effective drugs reducing the risk for stroke in atrial fibrillation (AF), but the benefits derived from such therapy depend on the international normalized ratio (INR) maintenance in a narrow therapeutic range. Here, we aimed to determine independent variables driving poor anticoagulation control [defined as a time in therapeutic range (TTR) &lt;65%] in a ‘real world’ national cohort of AF patients. Methods and results The SULTAN registry is a multicentre, prospective study, involving patients with non-valvular AF from 72 cardiology units expert in AF in Spain. At inclusion, all patients naïve for oral anticoagulation were started with VKAs…
Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists.
2018
BACKGROUND Although polypharmacy is associated with a negative clinical outcome in various settings and commonly observed in patients receiving oral anticoagulation therapy, evidence on the relevance for the clinical outcome of anticoagulated patients is currently limited. The aim of the study was to investigate the effect of polypharmacy on the clinical outcomes among patients taking phenprocoumon. DESIGN Prospective cohort study. SETTING Regular medical care. PARTICIPANTS Information on 2011 individuals receiving vitamin K antagonists was available for analysis from the prospective multicenter thrombEVAL study. MEASUREMENTS Data were obtained from clinical visits, computer-assisted interv…
Oral vitamin K effectively treats international normalised ratio (INR) values in excess of 10
2009
SummaryUnanticipated elevation of the INR is common in patients receiving warfarin. We performed a prospective cohort study of 107 warfarintreated patients with INR values of more than 10 who received a single 2.5 mg dose of oral vitamin K. During the first week, one patient experienced major bleeding, and one died. In the first 90 days after enrolment four patients had major bleeding (3.7%, 1.0% to 9.3%), eight patients (7.5%, 3.3% to 14.2%) died and two had objectively confirmed thromboembolism. Based on our low rate of observed major bleeding we conclude that 2.5 mg of oral vitamin K is a reasonable treatment for patients with INR values of more than 10 who are not actively bleeding.
Extra tension at electrode-nanowire adhesive contacts in nano-electromechanical devices
2017
Abstract We report a strong tangential component of the reaction force at electrode to nanowire adhesive contact which was previously established using electrostatic attraction. The reaction force tangential component absolute value was found to be comparable to or even bigger than the corresponding normal component. This effect is important for understanding of the mechanics of nano-electromechanical devices. Both the experiment and the corresponding theory are presented. Fitting of the obtained analytical solutions to experimental data was used to measure the reaction force acting at the contact for several nanowire-electrode configurations.
Non-linear systems under parametric white noise input: digital simulation and response
2005
Abstract Monte Carlo technique is constituted of three steps. Therefore, improving such technique in practice means, improving the procedure used in one of the three following steps: (i) sample paths of the stochastic input process, (ii) calculation of the outputs corresponding to the generated input samples by using methods of classical dynamics and (iii) estimating statistics of the output process from sample outputs related to the previous step. For linear and non-linear systems driven by parametric impulsive inputs such as normal or non-normal white noises, a general integration method requires a considerable reduction of the integration step when the impulse occurs, treating the impuls…
How to simulate normal data sets with the desired correlation structure
2010
The Cholesky decomposition is a widely used method to draw samples from multivariate normal distribution with non-singular covariance matrices. In this work we introduce a simple method by using singular value decomposition (SVD) to simulate multivariate normal data even if the covariance matrix is singular, which is often the case in chemometric problems. The covariance matrix can be specified by the user or can be generated by specifying a subset of the eigenvalues. The latter can be an advantage for simulating data sets with a particular latent structure. This can be useful for testing the performance of chemometric methods with data sets matching the theoretical conditions for their app…
Statistical validation of rival models for observable stochastic process and its identification
2011
In this paper, for statistical validation of rival (analytical or simulation) models collected for modeling observable process in stochastic system (say, transportation or service system), a uniformly most powerful invariant (UMPI) test is developed from the generalized maximum likelihood ratio (GMLR). This test can be considered as a result of a new approach to solving the Behrens-Fisher problem when covariance matrices of multivariate normal populations (compared with respect to their means) are different and unknown. The test makes use of an invariant statistic whose distribution, under the null hypothesis, does not depend on the unknown (nuisance) parameters. The sample size and thresho…
Adaptive Gaussian particle method for the solution of the Fokker-Planck equation
2012
The Fokker-Planck equation describes the evolution of the probability density for a stochastic ordinary differential equation (SODE). A solution strategy for this partial differential equation (PDE) up to a relatively large number of dimensions is based on particle methods using Gaussians as basis functions. An initial probability density is decomposed into a sum of multivariate normal distributions and these are propagated according to the SODE. The decomposition as well as the propagation is subject to possibly large numeric errors due to the difficulty to control the spatial residual over the whole domain. In this paper a new particle method is derived, which allows a deterministic error…