Search results for " nuclei"
showing 10 items of 602 documents
Central functional response to the novel peptide cannabinoid, hemopressin.
2013
Hemopressin is the first peptide ligand to be described for the CB₁ cannabinoid receptor. Hemopressin acts as an inverse agonist in vivo and can cross the blood-brain barrier to both inhibit appetite and induce antinociception. Despite being highly effective, synthetic CB₁ inverse agonists are limited therapeutically due to unwanted, over dampening of central reward pathways. However, hemopressin appears to have its effect on appetite by affecting satiety rather than reward, suggesting an alternative mode of action which might avoid adverse side effects. Here, to resolve the neuronal circuitry mediating hemopressin's actions, we have combined blood-oxygen-level-dependent, pharmacological-ch…
Search for neutrino emission from gamma-ray flaring blazars with the ANTARES telescope
2012
The ANTARES telescope observes a full hemisphere of the sky all the time with a duty cycle close to 100%. This makes it well suited for an extensive observation of neutrinos produced in astrophysical transient sources. In the surrounding medium of blazars, i.e. active galactic nuclei with their jets pointing almost directly towards the observer, neutrinos may be produced together with gamma-rays by hadronic interactions, so a strong correlation between neutrinos and gamma-rays emissions is expected. The time variability information of the studied source can be obtained by the gamma-ray light curves measured by the LAT instrument on-board the Fermi satellite. If the expected neutrino flux ob…
Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells
2021
Abstract DNA is intrinsically dynamic and folds transiently into alternative higher-order structures such as G-quadruplexes (G4s) and three-way DNA junctions (TWJs). G4s and TWJs can be stabilised by small molecules (ligands) that have high chemotherapeutic potential, either as standalone DNA damaging agents or combined in synthetic lethality strategies. While previous approaches have claimed to use ligands that specifically target either G4s or TWJs, we report here on a new approach in which ligands targeting both TWJs and G4s in vitro demonstrate cellular effects distinct from that of G4 ligands, and attributable to TWJ targeting. The DNA binding modes of these new, dual TWJ-/G4-ligands w…
Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
2021
Full list of authors: EHT MWL Science Working Group; Algaba, J. C.; Anczarski, J.; Asada, K.; Baloković, M.; Chandra, S.; Cui, Y. -Z.; Falcone, A. D.; Giroletti, M.; Goddi, C.; Hada, K.; Haggard, D.; Jorstad, S.; Kaur, A.; Kawashima, T.; Keating, G.; Kim, J. -Y.; Kino, M.; Komossa, S.; Kravchenko, E. V.; Krichbaum, T. P.; Lee, S. -S.; Lu, R. -S.; Lucchini, M.; Markoff, S.; Neilsen, J.; Nowak, M. A.; Park, J.; Principe, G.; Ramakrishnan, V.; Reynolds, M. T.; Sasada, M.; Savchenko, S. S.; Williamson, K. E.; Event Horizon Telescope Collaboration; Akiyama, Kazunori; Alberdi, Antxon; Alef, Walter; Anantua, Richard; Azulay, Rebecca; Baczko, Anne-Kathrin; Ball, David; Barrett, John; Bintley, Dan; …
Jet collimation in NGC 315
2021
VizieR online Data Catalogue associated with article published in journal Astronomy & Astrophysics with title 'Jet collimation in NGC 315 and other nearby AGN.' (bibcode: 2021A&A...647A..67B)
XMM-Newton survey of the ELAIS-S1 field
2008
The formation and evolution of cosmic structures can be probed by studying the evolution of the luminosity function of the Active Galactic Nuclei (AGNs), galaxies and clusters of galaxies and of the clustering of the X-ray active Universe, compared to the IR-UV active Universe. To this purpose, we have surveyed with XMM-Newton the central ~0.6{deg}^2^ region of the ELAIS-S1 field down to flux limits of ~5.5x10^-16^erg/cm^2^/s (0.5-2keV, soft band, S), ~2x10^-15^erg/cm^2^/s (2-10keV, hard band, H), and ~4x10^-15^erg/cm^2^/s (5-10keV, ultra hard band, HH). We present here the analysis of the XMM-Newton observations, the number counts in different energy bands and the clustering properties of …
A new sample of large angular size radio galaxies
2004
We present in this paper a detailed study of a new sample of large angular size FR I and FR II radio galaxies and compare the properties of the two classes. As expected, a pure morphology based distinction of FR Is and FR IIs corresponds to a break in total radio power. The radio cores in FR Is are also weaker than in FR IIs, although there is not a well defined break power. We find that asymmetry in the structure of the sample members must be the consequence of anisotropies in the medium where the lobes expand, with orientation playing a minor role. Moreover, literature data and our observations at kiloparsec scales suggest that the large differences between the structures of FR I and FR I…
The reverse transcription signature of N-1-methyladenosine in RNA-Seq is sequence dependent
2015
The combination of Reverse Transcription (RT) and high-throughput sequencing has emerged as a powerful combination to detect modified nucleotides in RNA via analysis of either abortive RT-products or of the incorporation of mismatched dNTPs into cDNA. Here we simultaneously analyze both parameters in detail with respect to the occurrence of N-1-methyladenosine (m1A) in the template RNA. This naturally occurring modification is associated with structural effects, but it is also known as a mediator of antibiotic resistance in ribosomal RNA. In structural probing experiments with dimethylsulfate, m1A is routinely detected by RT-arrest. A specifically developed RNA-Seq protocol was tailored to …
Should Vanishing Twin Pregnancies Be Systematically Excluded From Cell-Free Fetal DNA Testing?
2020
Objective To demonstrate the feasibility of cell-free DNA (cfDNA) testing in vanishing twin (VT) pregnancies in routine clinical practice. Methods Our study included 24 874 singleton and 206 VT consecutive pregnancies. Cell-free DNA was analyzed by massively parallel sequencing. Both aneuploidy analysis (chromosomes 13,18, 21, X, and Y) and fetal fraction estimation were performed according to an Illumina algorithm. Contaminant DNA contribution from the demised co-twin was studied in detail. Results VT pregnancies exhibited a higher prevalence of screen-positive cases (5.8% vs 2.5%), sex discrepancies (10.2% vs 0.05%), and false positive rates (FPR) (2.6% vs 0.3%) than singleton pregnancies…
Multicenter prospective study of concordance between embryonic cell-free DNA and trophectoderm biopsies from 1301 human blastocysts
2020
Background The recent identification of embryonic cell-free DNA in spent blastocyst media has opened a new era of possibilities for noninvasive embryo aneuploidy testing in assisted reproductive technologies. Yet, previous studies assessing a limited number of embryos reported variable concordance between embryonic cell-free DNA and trophectoderm biopsies, thus questioning the validity of this approach. Objective This study aimed to evaluate the concordance and reproducibility of testing embryonic cell-free DNA vs trophectoderm DNA obtained from the same embryo in a large sample of human blastocysts and to assess the contribution of the inner cell mass and trophectoderm to embryonic cell-fr…